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An in vivo study on the effect of coating stability on osteointegration performance of collagen/hyaluronic acid multilayer modified titanium implants 被引量:2
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作者 Haiyong Ao jiajia zong +2 位作者 Yanjiao Nie Yizao Wan Xiebin Zheng 《Bioactive Materials》 SCIE 2018年第1期97-101,共5页
Aseptic loosening of implant is one of the main causes of Ti-based implant failure.In our previous work,a novel stable collagen/hyaluronic acid(Col/HA)multilayer modified titanium coatings(TCs)was developed by layer-b... Aseptic loosening of implant is one of the main causes of Ti-based implant failure.In our previous work,a novel stable collagen/hyaluronic acid(Col/HA)multilayer modified titanium coatings(TCs)was developed by layer-by-layer(LBL)covalent immobilization technique,which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in vitro.In this study,a rabbit model with femur condyle defect was employed to compare the osteointegration performance of them.Results indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant contact.The Col/HA multilayer covalentimmobilized TC may reduce aseptic loosening of implant. 展开更多
关键词 Collagen I Hyaluronic acid LBL covalent immobilization STABILITY OSTEOINTEGRATION
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