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Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury 被引量:1
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作者 Jiang Cao Xiao Yu +10 位作者 Jingcheng Liu jiaju fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第11期2499-2512,共14页
The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arth... The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arthritis,and managing inflammatory cytokine storms.Although studies have shown the neuroprotective potential of ruxolitinib in neurological trauma,the exact mechanism by which it enhances functional recovery after spinal cord injury,particularly its effect on astrocytes,remains unclear.To address this gap,we established a mouse model of T10 spinal cord contusion and found that ruxolitinib effectively improved hindlimb motor function and reduced the area of spinal cord injury.Transcriptome sequencing analysis showed that ruxolitinib alleviated inflammation and immune response after spinal cord injury,restored EAAT2 expression,reduced glutamate levels,and alleviated excitatory toxicity.Furthermore,ruxolitinib inhibited the phosphorylation of JAK2 and STAT3 in the injured spinal cord and decreased the phosphorylation level of nuclear factor kappa-B and the expression of inflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factor-α.Additionally,in glutamate-induced excitotoxicity astrocytes,ruxolitinib restored EAAT2 expression and increased glutamate uptake by inhibiting the activation of STAT3,thereby reducing glutamate-induced neurotoxicity,calcium influx,oxidative stress,and cell apoptosis,and increasing the complexity of dendritic branching.Collectively,these results indicate that ruxolitinib restores glutamate homeostasis by rescuing the expression of EAAT2 in astrocytes,reduces neurotoxicity,and effectively alleviates inflammatory and immune responses after spinal cord injury,thereby promoting functional recovery after spinal cord injury. 展开更多
关键词 astrocytes EAAT2 EXCITOTOXICITY glutamate homeostasis JAK-STAT pathway locomotor function NEUROTOXICITY RUXOLITINIB spinal cord injury transcriptome analysis
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Risk assessment of fault water inrush during deep mining 被引量:1
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作者 Zhaodan Cao Qixiong Gu +1 位作者 Zhen Huang jiaju fu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2022年第2期423-434,共12页
With the gradual depletion of shallow coal resources,the Yanzhou mine in China will enter the lower coal seam mining phase.However,as mining depth increases,lower coal seam mining in Yanzhou is threatened by water inr... With the gradual depletion of shallow coal resources,the Yanzhou mine in China will enter the lower coal seam mining phase.However,as mining depth increases,lower coal seam mining in Yanzhou is threatened by water inrush in the Benxi Formation limestone and Ordovician limestone.The existing prediction models for the water burst at the bottom of the coal seam are less accurate than expected owing to various controlling factors and their intrinsic links.By analyzing the hydrogeological exploration data of the Baodian lower seam and combining the results of the water inrush coefficient method and the Yanzhou mine pressure seepage test,an evaluation model of the seepage barrier capacity of the fault was established.The evaluation results show the water of the underlying limestone aquifer in the Baodian mine area mainly threatens the lower coal mining through the fault fracture zone.The security of mining above confined aquifer in the Baodian mine area gradually decreases from southwest to northeast.By comparing the water inrush coefficient method and the evaluation model of fault impermeability,the results show the evaluation model based on seepage barrier conditions is closer to the actual situation when analyzing the water breakout situation at the working face. 展开更多
关键词 Lower coal seam Mining above confined aquifer Water inrush coefficient Water injection test Impermeability strength Water-inrush in fault
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Recent advances in p-block metal chalcogenide electrocatalysts for high-efficiency CO_(2) reduction
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作者 Fanrong Chen Ze-Cheng Yao +3 位作者 Zhen-Hua Lyu jiaju fu Xiaoling Zhang Jin-Song Hu 《eScience》 2024年第2期43-56,共14页
Electrocatalytic CO_(2) reduction(ECR)to high-value fuels and chemicals offers a promising conversion technology for achieving sustainable carbon cycles.In recent years,although great efforts have been made to develop... Electrocatalytic CO_(2) reduction(ECR)to high-value fuels and chemicals offers a promising conversion technology for achieving sustainable carbon cycles.In recent years,although great efforts have been made to develop highefficiency ECR catalysts,challenges remain in achieving high activity and long durability simultaneously.Taking advantage of the adjustable structure,tunable component,and the M–Ch(M¼Sn,In,Bi,etc.,Ch¼S,Se,Te)covalent bonds stabilized metal centers,the p-block metal chalcogenides(PMC)based electrocatalysts have shown great potential in converting CO_(2) into CO or formates.In addition,the unique p-block electron structure can suppress the competitive hydrogen evolution reaction and enhance the adsorption of ECR intermediates.Seeking to systematically understand the structure–activity relationship of PMC-based ECR catalysts,this review summarizes the recent advances in designing PMC electrocatalysts for CO_(2) reduction based on the fundamental aspects of heterogeneous ECR process,including advanced strategies for optimizing the intrinsic activity and improving the loading density of catalytic sites,constructing highly stable catalysts,and tuning product. 展开更多
关键词 Electrocatalytic CO_(2)reduction P-block metal chalcogenides Catalyst design strategies High-performance electrocatalysts
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Fight for carbon neutrality with state-of-the-art negative carbon emission technologies 被引量:3
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作者 jiaju fu Pan Li +4 位作者 Yuan Lin Huitong Du Hongzhi Liu Wenlei Zhu Hongqiang Ren 《Eco-Environment & Health》 2022年第4期259-279,共21页
After the Industrial Revolution,the ever-increasing atmospheric CO_(2)concentration has resulted in significant problems for human beings.Nearly all countries in the world are actively taking measures to fight for car... After the Industrial Revolution,the ever-increasing atmospheric CO_(2)concentration has resulted in significant problems for human beings.Nearly all countries in the world are actively taking measures to fight for carbon neutrality.In recent years,negative carbon emission technologies have attracted much attention due to their ability to reduce or recycle excess CO_(2)in the atmosphere.This review summarizes the state-of-the-art negative carbon emission technologies,from the artificial enhancement of natural carbon sink technology to the physical,chemical,or biological methods for carbon capture,as well as CO_(2)utilization and conversion.Finally,we expound on the challenges and outlook for improving negative carbon emission technology to accelerate the pace of achieving carbon neutrality. 展开更多
关键词 Carbon neutrality Renewable energy Negative carbon emission Carbon utilization Carbon footprint reduction Climate change mitigation
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