[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective t...[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective traditional Chinese medicine monomer compounds that intervene in the core targets of nonorganic sleep disorders, and molecular docking technology was used to verify the traditional Chinese medicine monomer compounds that meet the expected goals.[Results] Based on the storm related targets of nonorganic sleep disorders, five monomer compounds of traditional Chinese medicine were screened, namely paeoniflorin, chlorogenic acid, quercetin, baicalin, and ginsenoside Rg1. These monomer compounds of traditional Chinese medicine act on multiple targets such as CASP8, IKBKB, IL1B, IL6, CXCL8, etc. , thereby playing a role in calming the mind and improving sleep.[Conclusions] These monomer compounds of traditional Chinese medicine had potential pharmacological effects on nonorganic sleep disorders and high value in subsequent experiments and clinical applications.展开更多
基金Supported by the Key Project of TCM in Hubei Province(ZY2023F074).
文摘[Objectives] To find effective monomer compounds of traditional Chinese medicine targeting nonorganic sleep disorders.[Methods] The reverse thinking of "target-compound" was adopted to search for effective traditional Chinese medicine monomer compounds that intervene in the core targets of nonorganic sleep disorders, and molecular docking technology was used to verify the traditional Chinese medicine monomer compounds that meet the expected goals.[Results] Based on the storm related targets of nonorganic sleep disorders, five monomer compounds of traditional Chinese medicine were screened, namely paeoniflorin, chlorogenic acid, quercetin, baicalin, and ginsenoside Rg1. These monomer compounds of traditional Chinese medicine act on multiple targets such as CASP8, IKBKB, IL1B, IL6, CXCL8, etc. , thereby playing a role in calming the mind and improving sleep.[Conclusions] These monomer compounds of traditional Chinese medicine had potential pharmacological effects on nonorganic sleep disorders and high value in subsequent experiments and clinical applications.
