A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-c...A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical cou-pling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclicα-halides andα-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions.With multi distinct sites for structural modification,a di-verse pool of chiral N,N,P-ligands is readily accessed,allowing for rapid optimization of the ligand structure for a specific substrate.Notably,the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.展开更多
基金We are grateful to the National Natural Science Foundation of China(Nos.22071073,21772218 and 21821002)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences and Central China Normal University(CCNU).
文摘A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical cou-pling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclicα-halides andα-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions.With multi distinct sites for structural modification,a di-verse pool of chiral N,N,P-ligands is readily accessed,allowing for rapid optimization of the ligand structure for a specific substrate.Notably,the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.
