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Rare variants in novel and known genes associated with primary angle closure glaucoma based on whole exome sequencing of 549 probands
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作者 Wenmin Sun Xueshan Xiao +5 位作者 Shiqiang Li jiamin ouyang Xueqing Li Xiaoyun Jia Xing Liu Qingjiong Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2019年第7期353-357,共5页
Primary angle closure glaucoma(PACG)is one of the most common causes of irreversible blindness in Asia and about 80%of PACG are present in Asia(Song et al.,2017).Genetics plays an important role in the development of ... Primary angle closure glaucoma(PACG)is one of the most common causes of irreversible blindness in Asia and about 80%of PACG are present in Asia(Song et al.,2017).Genetics plays an important role in the development of PACG(Gramer et al.,2014).Recently,eight common SNPs were found to be strongly associated with PACG(Vithana et al.,2012;Khor et al.,2016)and mutations in MYRF cause high hyperopia accompanied with PACG(Xiao et al.,2019). 展开更多
关键词 IRREVERSIBLE BLINDNESS HYPEROPIA
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