Functionalized organozinc reagents can easily under 1, 4-addition reaction withunsaturated esters in the presence of catalytic amount of Ni (acac)_2 and tertiary ammes under verymild conditions to give the products in...Functionalized organozinc reagents can easily under 1, 4-addition reaction withunsaturated esters in the presence of catalytic amount of Ni (acac)_2 and tertiary ammes under verymild conditions to give the products in excellent yields.展开更多
A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first...A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first reported and determined by IR, MS, 1H-/13C-NMR spectra.among them the Shae of 1 was further defined by X-ray diffraction展开更多
Functionalized organozinc reagents can easily conduct 1,4-addition reaction with unsaturated esters in the presence of Cu(OAc)2 and LiCl under very Anld conditions to give the products in excellent yields.
Two new compounds, ergostan-3.24-diol(4) and 2-hydroxy-lappaol B(8) along with twelve known compounds have been isolated fron the aerial parts of Sanssurea gossypiphora D.Don. Their structures have been elucidated by ...Two new compounds, ergostan-3.24-diol(4) and 2-hydroxy-lappaol B(8) along with twelve known compounds have been isolated fron the aerial parts of Sanssurea gossypiphora D.Don. Their structures have been elucidated by spectral analysis and chealcal aethods.展开更多
Natural killer(NK)cells,a subgroup of innate lymphoid cells,act as the first line of defense against cancer.Although some evidence shows that NK cells can develop in secondary lymphoid tissues,NK cells develop mainly ...Natural killer(NK)cells,a subgroup of innate lymphoid cells,act as the first line of defense against cancer.Although some evidence shows that NK cells can develop in secondary lymphoid tissues,NK cells develop mainly in the bone marrow(BM)and egress into the blood circulation when they mature.They then migrate to and settle down in peripheral tissues,though some special subsets home back into the BM or secondary lymphoid organs.Owing to its success in allogeneic adoptive transfer for cancer treatment and its“off-the-shelf”potential,NK cell-based immunotherapy is attracting increasing attention in the treatment of various cancers.However,insufficient infiltration of adoptively transferred NK cells limits clinical utility,especially for solid tumors.Expansion of NK cells or engineered chimeric antigen receptor(CAR)NK cells ex vivo prior to adoptive transfer by using various cytokines alters the profiles of chemokine receptors,which affects the infiltration of transferred NK cells into tumor tissue.Several factors control NK cell trafficking and homing,including cell-intrinsic factors(e.g.,transcriptional factors),cell-extrinsic factors(e.g.,integrins,selectins,chemokines and their corresponding receptors,signals induced by cytokines,sphingosine-1-phosphate(S1P),etc.),and the cellular microenvironment.Here,we summarize the profiles and mechanisms of NK cell homing and trafficking at steady state and during tumor development,aiming to improve NK cell-based cancer immunotherapy.展开更多
文摘Functionalized organozinc reagents can easily under 1, 4-addition reaction withunsaturated esters in the presence of catalytic amount of Ni (acac)_2 and tertiary ammes under verymild conditions to give the products in excellent yields.
文摘A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first reported and determined by IR, MS, 1H-/13C-NMR spectra.among them the Shae of 1 was further defined by X-ray diffraction
文摘Functionalized organozinc reagents can easily conduct 1,4-addition reaction with unsaturated esters in the presence of Cu(OAc)2 and LiCl under very Anld conditions to give the products in excellent yields.
文摘Two new compounds, ergostan-3.24-diol(4) and 2-hydroxy-lappaol B(8) along with twelve known compounds have been isolated fron the aerial parts of Sanssurea gossypiphora D.Don. Their structures have been elucidated by spectral analysis and chealcal aethods.
基金supported by National Natural Science Foundation of China(Nos.81922068 and 81874313)Y.D.This study was also supported by funding from the National Key Research and Development Project(Nos.2020YFA0113500 and 2019YFA0111200) Y.D.This study was also supported by National undergraduate training program for innovation and entrepreneurship(No.2020XBK28)to Y.D.
文摘Natural killer(NK)cells,a subgroup of innate lymphoid cells,act as the first line of defense against cancer.Although some evidence shows that NK cells can develop in secondary lymphoid tissues,NK cells develop mainly in the bone marrow(BM)and egress into the blood circulation when they mature.They then migrate to and settle down in peripheral tissues,though some special subsets home back into the BM or secondary lymphoid organs.Owing to its success in allogeneic adoptive transfer for cancer treatment and its“off-the-shelf”potential,NK cell-based immunotherapy is attracting increasing attention in the treatment of various cancers.However,insufficient infiltration of adoptively transferred NK cells limits clinical utility,especially for solid tumors.Expansion of NK cells or engineered chimeric antigen receptor(CAR)NK cells ex vivo prior to adoptive transfer by using various cytokines alters the profiles of chemokine receptors,which affects the infiltration of transferred NK cells into tumor tissue.Several factors control NK cell trafficking and homing,including cell-intrinsic factors(e.g.,transcriptional factors),cell-extrinsic factors(e.g.,integrins,selectins,chemokines and their corresponding receptors,signals induced by cytokines,sphingosine-1-phosphate(S1P),etc.),and the cellular microenvironment.Here,we summarize the profiles and mechanisms of NK cell homing and trafficking at steady state and during tumor development,aiming to improve NK cell-based cancer immunotherapy.
