Recently, the layered transition metal dichalcogenide 1 T MoTe2 has attracted considerable attention due to its non-saturating magnetoresistance, type-II Weyl semimetal properties, superconductivity, and potential can...Recently, the layered transition metal dichalcogenide 1 T MoTe2 has attracted considerable attention due to its non-saturating magnetoresistance, type-II Weyl semimetal properties, superconductivity, and potential candidate for twodimensional（2 D） topological insulator in the single-and few-layer limit. Here in this work, we perform systematic transport measurements on thin flakes of MoTe2 prepared by mechanical exfoliation. We find that MoTe2 flakes are superconducting and have an onset superconducting transition temperature Tc up to 5.3 K, which significantly exceeds that of its bulk counterpart. The in-plane upper critical field(Hc2||) is much higher than the Pauli paramagnetic limit, implying that the MoTe2 flakes have Zeeman-protected Ising superconductivity. Furthermore, the Tc and Hc2|| can be tuned by up to 320 mK and 400 mT by applying a gate voltage. Our result indicates that MoTe2 flake is a good candidate for studying exotic superconductivity with nontrivial topological properties.展开更多
Long waiting delays for users and significant imbalances in vehicle distribution are bothering traditional station-based one-way electric car-sharing system operators.To address the problems above,a“demand forecast-s...Long waiting delays for users and significant imbalances in vehicle distribution are bothering traditional station-based one-way electric car-sharing system operators.To address the problems above,a“demand forecast-station status judgement-vehicle relocation”multistage dynamic relocation algorithm based on the automatic formation cruising technology was proposed in this study.In stage one,a novel trip demand forecast model based on the long short-term memory network was established to predict users'car-pickup and car-return order volumes at each station.In stage two,a dynamic threshold interval was determined by combining the forecast results with the actual vehicle distribution among stations to evaluate the status of each station.Then vehicle-surplus,vehicleinsufficient,vehicle-normal stations,and the number of surplus or insufficient vehicles for each station were counted.In stage three,setting driving mileage and carbon emission as the optimization objectives,an integer linear programming mathematical model was constructed and the optimal vehicle relocation scheme was obtained by the commercial solver Gurobi.Setting 43 stations and 187 vehicles in Jiading District,Shanghai,China,as a case study,results showed that rapid vehicle rebalancing among stations with minimum carbon emissions could be realized within 15 min and the users’car-pickup and car-return demands could be fully satisfied without any refusal.展开更多
Objective:The aim of this study is to evaluate the effectiveness and safety of xiyanping injection(XYPI)in the treatment of children with bronchopneumonia.Methods:Asystematic and comprehensive search was conducted in ...Objective:The aim of this study is to evaluate the effectiveness and safety of xiyanping injection(XYPI)in the treatment of children with bronchopneumonia.Methods:Asystematic and comprehensive search was conducted in the domestic and foreign electronic databases CNKI,SinoMed,VIP,WanFang DATA,PubMed,The Cochrane Library,Embase,Web of Science,Clinical‑Trials.gov,and the search date ended on May 30,2019.Inclusion criteria:(1)the types of studies included were randomized controlled trials;(2)the study participants were infants and children with a clear diagnosis of bronchopneumonia,without gender and ethnic restrictions;(3)the intervention test group was XYPI or the control group plus XYPI.The control group was routine treatment(RT)(basic treatment such as fever,cough and asthma,oxygen inhalation,anti‑infection,maintaining water,electrolyte balance,etc.)or other Western medicine or RT+other Western medicine treatment.Except for XYPI,the two groups were consistent in intervention measures.According to the Cochrane Handbook,5.1 evaluation standard and a meta‑analysis of the final included studies was performed using RevMan 5.3 software.Results:Atotal of 57 studies were included,with a total sample size of 8454 cases,of which 4255 were in the experimental group and 4199 were in the control group.Meta‑analysis results showed that(1)Total effective rate:XYPI group was better than the control group(relative risk[RRRT]=1.25,95%confidence interval[CI][1.15,1.36],P<0.00001;RRRT+RBVI=1.18,95%CI[1.09,1.29],P<0.0001;RR antibiotic=1.16,95%CI[1.09,1.24],P<0.00001,RRRT+antibiotic=1.22,95%CI[1.16,1.27],P<0.00001);antipyretic time:XYPI group was better than the control group(mean difference[MDRT]=−0.97,95%CI[−1.17,−0.76],P<0.00001;MDRT+antibiotic=−2.28,95%CI[−2.88,−1.67],P<0.00001;MDRT+RBVI=−1.51,95%CI[−1.81,−1.21],P<0.00001;cough disappearing time:XYPI group was better than the control group(MDRT=−1.37,95%CI[−1.74,−1.00],P<0.00001;MDRT+antibiotic=−1.71,95%CI[−2.04,−1.37],P<0.00001;MDRT+RBVI=−1.51,95%CI[−2.15,−0.86],P<0.00001);disappearance time of lung rales:XYPI group was better than the control group(MDRT=−1.11,95%CI[−1.35,−0.88],P<0.00001;MDRT+RBVI=−1.63,95%CI[−2.23,−1.03],P<0.00001).The difference was statistically significant;(2)Of the 57 studies(a total of 8454 cases),29 studies reported adverse reactions,of which 18 studies did not find adverse reactions,and 11 studies reported adverse reactions such as nausea,vomiting,and rash after medication in both groups.(3)The funnel chart indicated potential publication bias.Conclusion:Based on the existing clinical evidence,XYPI can have a certain effect on the treatment of children with bronchopneumonia,and it is not yet possible to conclude its safety evaluation.Moreover,due to the low quality of the included studies,this evidence is still used with cautious clinically.展开更多
The objective of the study was to systematically evaluate the efficacy and safety of Shenfu injection in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).A total of 15...The objective of the study was to systematically evaluate the efficacy and safety of Shenfu injection in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).A total of 15 randomized controlled trials involving 1198 patients were included.The results of meta-analysis showed that compared with the control group,the experimental group can improve the total clinical effective rate in AECOPD patients(relative risk=1.15,95%confidence interval[CI][1.09,1.21],P<0.00001),improve the pulmonary function levels:forced expiratory volume in one second(FEV1)(standardized mean difference=1.88,95%CI[0.89,2.88],P=0.0002)and the FEV1/forced vital capacity(FVC)ratio(FEV1/FVC)(mean difference[MD]=3.96,95%CI[2.74,5.19],P<0.00001);improve the arterial blood oxygen partial pressure(MD=6.03,95%CI[4.58,7.48],P<0.00001),and reduce the arterial blood partial pressure of carbon dioxide(MD=-4.59,95%CI[-6.91,-2.26],P=0.00001),and the white blood cell count in pulmonary infection may be improved(MD=-1.16,95%CI[-1.63,-0.68],P<0.00001).The study showed that the efficacy of experimental group in the treatment of AECOPD is better than control group.Due to the limitation of the number and quality of included studies,this conclusion needs more high quality studies to confirm.展开更多
基金Project supported by the Guangdong Innovative and Entrepreneurial Research Team Program,China(Grant No.2016ZT06D348)the National Natural Science Foundation of China(Grant No.11874193)the Shenzhen Fundamental Subject Research Program,China(Grant Nos.JCYJ20170817110751776 and JCYJ20170307105434022)
文摘Recently, the layered transition metal dichalcogenide 1 T MoTe2 has attracted considerable attention due to its non-saturating magnetoresistance, type-II Weyl semimetal properties, superconductivity, and potential candidate for twodimensional（2 D） topological insulator in the single-and few-layer limit. Here in this work, we perform systematic transport measurements on thin flakes of MoTe2 prepared by mechanical exfoliation. We find that MoTe2 flakes are superconducting and have an onset superconducting transition temperature Tc up to 5.3 K, which significantly exceeds that of its bulk counterpart. The in-plane upper critical field(Hc2||) is much higher than the Pauli paramagnetic limit, implying that the MoTe2 flakes have Zeeman-protected Ising superconductivity. Furthermore, the Tc and Hc2|| can be tuned by up to 320 mK and 400 mT by applying a gate voltage. Our result indicates that MoTe2 flake is a good candidate for studying exotic superconductivity with nontrivial topological properties.
基金supported by the Science and Technology Project of State Grid Corporation of China“Research on urban power grid dispatching technology for large-scale electric vehicles integration”(grant number 5108202119040A-0-0-00)。
文摘Long waiting delays for users and significant imbalances in vehicle distribution are bothering traditional station-based one-way electric car-sharing system operators.To address the problems above,a“demand forecast-station status judgement-vehicle relocation”multistage dynamic relocation algorithm based on the automatic formation cruising technology was proposed in this study.In stage one,a novel trip demand forecast model based on the long short-term memory network was established to predict users'car-pickup and car-return order volumes at each station.In stage two,a dynamic threshold interval was determined by combining the forecast results with the actual vehicle distribution among stations to evaluate the status of each station.Then vehicle-surplus,vehicleinsufficient,vehicle-normal stations,and the number of surplus or insufficient vehicles for each station were counted.In stage three,setting driving mileage and carbon emission as the optimization objectives,an integer linear programming mathematical model was constructed and the optimal vehicle relocation scheme was obtained by the commercial solver Gurobi.Setting 43 stations and 187 vehicles in Jiading District,Shanghai,China,as a case study,results showed that rapid vehicle rebalancing among stations with minimum carbon emissions could be realized within 15 min and the users’car-pickup and car-return demands could be fully satisfied without any refusal.
基金National Key R&D Program of China(2018YFC1707400)Funding for Basic Scientific Research Business Expenses of Central-Level Non-Profit Research Institutes(Z0597)。
文摘Objective:The aim of this study is to evaluate the effectiveness and safety of xiyanping injection(XYPI)in the treatment of children with bronchopneumonia.Methods:Asystematic and comprehensive search was conducted in the domestic and foreign electronic databases CNKI,SinoMed,VIP,WanFang DATA,PubMed,The Cochrane Library,Embase,Web of Science,Clinical‑Trials.gov,and the search date ended on May 30,2019.Inclusion criteria:(1)the types of studies included were randomized controlled trials;(2)the study participants were infants and children with a clear diagnosis of bronchopneumonia,without gender and ethnic restrictions;(3)the intervention test group was XYPI or the control group plus XYPI.The control group was routine treatment(RT)(basic treatment such as fever,cough and asthma,oxygen inhalation,anti‑infection,maintaining water,electrolyte balance,etc.)or other Western medicine or RT+other Western medicine treatment.Except for XYPI,the two groups were consistent in intervention measures.According to the Cochrane Handbook,5.1 evaluation standard and a meta‑analysis of the final included studies was performed using RevMan 5.3 software.Results:Atotal of 57 studies were included,with a total sample size of 8454 cases,of which 4255 were in the experimental group and 4199 were in the control group.Meta‑analysis results showed that(1)Total effective rate:XYPI group was better than the control group(relative risk[RRRT]=1.25,95%confidence interval[CI][1.15,1.36],P<0.00001;RRRT+RBVI=1.18,95%CI[1.09,1.29],P<0.0001;RR antibiotic=1.16,95%CI[1.09,1.24],P<0.00001,RRRT+antibiotic=1.22,95%CI[1.16,1.27],P<0.00001);antipyretic time:XYPI group was better than the control group(mean difference[MDRT]=−0.97,95%CI[−1.17,−0.76],P<0.00001;MDRT+antibiotic=−2.28,95%CI[−2.88,−1.67],P<0.00001;MDRT+RBVI=−1.51,95%CI[−1.81,−1.21],P<0.00001;cough disappearing time:XYPI group was better than the control group(MDRT=−1.37,95%CI[−1.74,−1.00],P<0.00001;MDRT+antibiotic=−1.71,95%CI[−2.04,−1.37],P<0.00001;MDRT+RBVI=−1.51,95%CI[−2.15,−0.86],P<0.00001);disappearance time of lung rales:XYPI group was better than the control group(MDRT=−1.11,95%CI[−1.35,−0.88],P<0.00001;MDRT+RBVI=−1.63,95%CI[−2.23,−1.03],P<0.00001).The difference was statistically significant;(2)Of the 57 studies(a total of 8454 cases),29 studies reported adverse reactions,of which 18 studies did not find adverse reactions,and 11 studies reported adverse reactions such as nausea,vomiting,and rash after medication in both groups.(3)The funnel chart indicated potential publication bias.Conclusion:Based on the existing clinical evidence,XYPI can have a certain effect on the treatment of children with bronchopneumonia,and it is not yet possible to conclude its safety evaluation.Moreover,due to the low quality of the included studies,this evidence is still used with cautious clinically.
基金funded by the Special Fund for Basic Scientific Research Expenses of Public Welfare Research Institutes at the central level(Z0597)。
文摘The objective of the study was to systematically evaluate the efficacy and safety of Shenfu injection in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).A total of 15 randomized controlled trials involving 1198 patients were included.The results of meta-analysis showed that compared with the control group,the experimental group can improve the total clinical effective rate in AECOPD patients(relative risk=1.15,95%confidence interval[CI][1.09,1.21],P<0.00001),improve the pulmonary function levels:forced expiratory volume in one second(FEV1)(standardized mean difference=1.88,95%CI[0.89,2.88],P=0.0002)and the FEV1/forced vital capacity(FVC)ratio(FEV1/FVC)(mean difference[MD]=3.96,95%CI[2.74,5.19],P<0.00001);improve the arterial blood oxygen partial pressure(MD=6.03,95%CI[4.58,7.48],P<0.00001),and reduce the arterial blood partial pressure of carbon dioxide(MD=-4.59,95%CI[-6.91,-2.26],P=0.00001),and the white blood cell count in pulmonary infection may be improved(MD=-1.16,95%CI[-1.63,-0.68],P<0.00001).The study showed that the efficacy of experimental group in the treatment of AECOPD is better than control group.Due to the limitation of the number and quality of included studies,this conclusion needs more high quality studies to confirm.
