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Chitosan nanoparticles crosslinked by glycidoxypropyltrimethoxysilane for pH triggered release of protein 被引量:4
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作者 Ai wu Pan Bei Bei wu jian min wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第1期79-83,共5页
pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate (TPP) a... pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate (TPP) and glycidoxypropyltrimethoxysilane (GPTMS). Compared with TPP crosslinked chitosan particles, the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range. Fluorescein isothiocyanate (FITC) labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pH- responsive drug delivery materials. 展开更多
关键词 CHITOSAN NANOPARTICLES pH-response Drug delivery Controlled release PROTEIN
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Silica-supported Macroporous Chitosan Bead for Affinity Purification of Trypsin Inhibitor
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作者 Feng Na XI jian min wu ming ming LUAN 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第8期1089-1092,共4页
Macroporous cross-linking chitosan layer coated on silica gel (CTS-SiO2) was prepared by phase inversion and polyethylene glycol (PEG)molecular imprinting methods. Formation of macroporous surtace was investigated... Macroporous cross-linking chitosan layer coated on silica gel (CTS-SiO2) was prepared by phase inversion and polyethylene glycol (PEG)molecular imprinting methods. Formation of macroporous surtace was investigated by scanning electron microscopy (SEM) and BET analysis.The prepared bead was activated by reacting with 1,2-ethylene digiycidyl ether for introducing epoxy groups, and trypsin could be efficiently immobilized on the bead as a biospecific ligand.The bead bearing trypsin was employed to purify trypsin inhibitor (TIs) from egg white as affinity adsorbent. 展开更多
关键词 CHITOSAN SILICA trypsin inhibitor TRYPSIN affinity purification.
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