Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,"missing"Men delian phe no typ...Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,"missing"Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated.展开更多
Early embryonic development is a complex process.The zygote undergoes several rounds of division to form a blastocyst,and during this process,the zygote undergoes the maternal-to-zygotic transition to gain control of ...Early embryonic development is a complex process.The zygote undergoes several rounds of division to form a blastocyst,and during this process,the zygote undergoes the maternal-to-zygotic transition to gain control of embryonic development and makes two cell fate decisions to differentiate into an embryonic and two extra-embryonic lineages.With the use of new molecular biotechnologies and animal models,we can now further study the molecular mechanisms of early embryonic development and the pathological causes of early embryonic arrest.Here,we first summarize the known molecular regulatory mechanisms of early embryonic development in mice.Then we discuss the pathological factors leading to the early embryonic arrest.We hope that this review will give researchers a relatively complete view of the physiology and pathology of early embryonic development.展开更多
文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,"missing"Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated.
基金the National Key Research and Development Program of China(2021YFC2700100)the National Natural Science Foundation of China(32130029,81725006,82171643,81971450,and 82101746).
文摘Early embryonic development is a complex process.The zygote undergoes several rounds of division to form a blastocyst,and during this process,the zygote undergoes the maternal-to-zygotic transition to gain control of embryonic development and makes two cell fate decisions to differentiate into an embryonic and two extra-embryonic lineages.With the use of new molecular biotechnologies and animal models,we can now further study the molecular mechanisms of early embryonic development and the pathological causes of early embryonic arrest.Here,we first summarize the known molecular regulatory mechanisms of early embryonic development in mice.Then we discuss the pathological factors leading to the early embryonic arrest.We hope that this review will give researchers a relatively complete view of the physiology and pathology of early embryonic development.
