不同预时效挤压态Mg−Gd−Y−Zn−Zr合金的再结晶行为和强化机制

通过控制预时效时间制备3种不同状态的试样,研究不同预时效状态对挤压态Mg−9.5Gd−4Y−2.2Zn−0.5Zr(质量分数,%)合金的动态再结晶行为(DRX)和性能的影响。结果表明,欠时效挤压(UAE)样品的细晶体积分数为17.4%,而峰时效挤压(PAE)和过时效挤压(OAE)样品的细晶体积分数分别达到89.7%和50.4%。在晶粒内部和晶界处分布的致密、细小的β颗粒相通过粒子激发形核机制显著提高了形核位点和位错密度。然而,致密针状γ'相抑制位错滑移,延迟DRX形核。PEA和OAE样品中细小晶粒的差异归因于原始颗粒相的数量和尺寸的不同,而其拉伸性能的差异归因于不同的显微组织。由于晶界强化和析出强化机制的贡献更大,PAE样品具有更优异的拉伸性能。

钻柱腐蚀疲劳寿命评价和影响因素分析

油气钻井过程中钻柱受力复杂,容易发生断裂情况,根据现场情况评价钻柱腐蚀疲劳寿命可以为钻柱安全使用提供依据。从现场实用角度,通过轴向力、循环应力和疲劳极限的计算,对比了基于疲劳系数、寿命百分数和旋转计数的钻柱疲劳评价方法,并考虑了腐蚀的影响。分析结果表明,当在严重狗腿度的井段钻进时,弯曲应力和屈曲增加将加快钻柱疲劳失效;当对应的机械钻速降低、转速增加时,钻柱的剩余使用寿命将进一步降低;当发生较严重的腐蚀时,钻柱剩余使用寿命将迅速降低。在高抗拉井段和狗腿度变化大的井段的钻柱应定期倒换使用,以保障现场钻具安全规范使用。

铁山坡高含硫气藏安全快速钻井技术优化与应用

针对铁山坡气藏硫化氢含量高(最高达222.30 g/m^(3))、嘉五以上地层倾角大(最大倾角25°)、须家河组研磨性强、嘉陵江组高压盐水侵、飞仙关组地层压力系数低等难题,开展了套管柱、井口装置、钻具抗硫材质优选,优化了铁山坡区块的井身结构,优选了高陡构造防斜提速工具,形成了铁山坡高含硫气藏安全快速钻井技术。现场应用效果表明,优选的抗硫钻具、套管柱、井口装置满足了高含硫气藏安全高效开发的要求;四开井身结构有效解决了上部地层井漏、垮塌、盐水侵的问题,降低了飞仙关高含硫层段的井控风险;优选了垂钻工具、钻头和旋导工具,铁山坡气田平均机械钻速由1.85 m/h提速到3.61 m/h,铁山坡6口井平均钻井周期缩短了16.11%。该研究成果为后续川东北高含硫气藏的安全快速钻井提供了技术支撑。

光照、氮素对杂交水稻干物质积累、分配和产量形成的影响

为了提高西南喀斯特山区的水稻产量,以Y两优900和宜香优2115为材料,采用裂区试验设计,设置花后遮光为主区因素(自然光照和遮光40%),氮肥为副区因素(90、180、270 kg/hm^(2)),研究光照、氮素及其互作对杂交水稻干物质积累、转运和产量形成的影响。结果表明:同一氮肥水平下,花后遮光40%可显著提高干物质转运量、转运率和贡献率,但也显著降低了花后干物质量、总干物质量、收获指数和结实率,最终导致水稻实际产量显著降低27.0%~31.3%。相同光照条件下,增施氮肥可显著提高有效穗数、单位面积总颖花数、干物质积累与转运量、收获指数和产量。在弱光条件下,增施氮肥能提高干物质转运量、转运率、贡献率和总颖花数,并且总干物质量、收获指数和结实率随着施氮量增多而提高,从而降低了花后弱光造成的产量损失。因此,在西南寡照区,适当增加氮肥的施用,扩大前期的群体和干物质积累量,能有效地补偿后期弱光造成的产量损失。

Cloud Top Pressure Retrieval Using Polarized and Oxygen A-band Measurements from GF5 and PARASOL Satellites

Cloud top pressure(CTP)is one of the critical cloud properties that significantly affects the radiative effect of clouds.Multi-angle polarized sensors can employ polarized bands(490 nm)or O_(2)A-bands(763 and 765 nm)to retrieve the CTP.However,the CTP retrieved by the two methods shows inconsistent results in certain cases,and large uncertainties in low and thin cloud retrievals,which may lead to challenges in subsequent applications.This study proposes a synergistic algorithm that considers both O_(2)A-bands and polarized bands using a random forest(RF)model.LiDAR CTP data are used as the true values and the polarized and non-polarized measurements are concatenated to train the RF model to determine CTP.Additionally,through analysis,we proposed that the polarized signal becomes saturated as the cloud optical thickness(COT)increases,necessitating a particular treatment for cases where COT<10 to improve the algorithm's stability.The synergistic method was then applied to the directional polarized camera(DPC)and Polarized and Directionality of the Earth’s Reflectance(POLDER)measurements for evaluation,and the resulting retrieval accuracy of the POLDER-based measurements(RMSEPOLDER=205.176 hPa,RMSEDPC=171.141 hPa,R^(2)POLDER=0.636,R^(2)DPC=0.663,respectively)were higher than that of the MODIS and POLDER Rayleigh pressure measurements.The synergistic algorithm also showed good performance with the application of DPC data.This algorithm is expected to provide data support for atmosphere-related fields as an atmospheric remote sensing algorithm within the Cloud Application for Remote Sensing,Atmospheric Radiation,and Updating Energy(CARE)platform.

Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and meta-analysis.Methods:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were included.Results:Thirteen studies were included.Selexipag led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good effects.When treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage group.This finding is important for guiding individualized treatments.

Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the first-line recommended treatment for advanced HCC,with a median survival time of only about 2.7-6 months.In this case report,we present the case of a patient with portal and hepatic vein cancerous thrombosis who achieved pathologic complete response after conversion therapy.CASE SUMMARY In our center,a patient with giant HCC combined with portal vein tumor thrombus and hepatic vein tumor thrombus was treated with transcatheter arterial chemoembolization(TACE),radiotherapy,targeted therapy and immunotherapy,and was continuously given icaritin soft capsules for oral regulation.After 7 months of conversion therapy,the patient's tumor shrank and the tumor thrombus subsided significantly.The pathology of surgical resection was in complete remission,and there was no progression in the postoperative follow-up for 7 months,which provided a basis for the future strategy of combined conversion therapy.CONCLUSION In this case,atezolizumab,bevacizumab,icaritin soft capsules combined with radiotherapy and TACE had a good effect.For patients with hepatocellular carcinoma combined with hepatic vein/inferior vena cava tumor thrombus,adopting a high-intensity,multimodal proactive strategy under the guidance of multidisciplinary team(MDT)is an important attempt to break through the current treatment dilemma.

Uterine epithelioid trophoblastic tumor with the main manifestation of increased human chorionic gonadotropin:A case report

BACKGROUND Epithelioid trophoblastic tumor(ETT)is an extremely rare malignant gestational trophoblastic neoplasm commonly presenting with abnormal vaginal bleeding,abdominal pain,and increased human chorionic gonadotropin(hCG).This study reported a case of uterine ETT with the main manifestation being increased hCG.CASE SUMMARY A 39-year-old female was referred to the Ningbo Maternal and Child Hospital of China in December 2022,complaining of increased hCG levels for 1 month.Magnetic resonance imaging revealed gestational trophoblastic tumor,and hysteroscopic electrotomy and curettage of intrauterine hyperplasia were performed.The patient was diagnosed with uterine ETT through postoperative pathological examination and immunohistochemical results.Total laparoscopic hysterectomy and bilateral salpingectomy were performed,and hCG levels returned to normal.The patient was without recurrence during the postoperative 3-month follow-up.CONCLUSION This study reported a case of uterine ETT with the main manifestation being increased hCG,highlighting that ETT should be considered in the presence of abnormal hCG.A total laparoscopic hysterectomy is recommended.

Giant vascular malformations invading the skull:A case report

BACKGROUND Vascular malformations(VMs)arise as a result of errors in the process of angiogenesis and are usually present at birth,but may not become apparent until after birth.However,giant VMs of the head and face are uncommon,with few reported cases,and the prognosis for their surgical intervention is unclear.CASE SUMMARY A 12-year-old girl was admitted to the hospital with findings of an enlarged right temporal scalp.After admission,computed tomography(CT)angiography of cerebral ateries showed a right occlusal gap and a right temporal artery venous malformation.Furthermore,cerebral angiography showed a right temporal lobe VM with multiple vessels supplying blood.The patient underwent surgery to remove the malformed vessels and the eroded skull.Two hours after the surgery,the patient's right pupil was dilated,and an urgent CT scan of the skull showed a right subdural haematoma under the incision,which was urgently removed by a second operation.After surgery,we gave continuous antibiotic anti-infection treatment,and the patient recovered well and was discharged two weeks later.CONCLUSION Surgical removal of giant haemangiomas is risky and adequate preoperative(including interventional embolisation)and intraoperative preparations should be made.

基于有限元法的含腐蚀缺陷钻杆剩余抗拉强度分析

基于有限元法研究含腐蚀缺陷钻杆的剩余抗拉强度问题,分别讨论轴向腐蚀长度、环向腐蚀长度、腐蚀深度、腐蚀半径等因素对钻杆剩余抗拉强度的影响。研究结果表明:对于均匀腐蚀缺陷钻杆,其剩余抗拉强度受腐蚀深度的影响最大,受环向腐蚀长度的影响次之,受轴向腐蚀长度的影响最小;对于点腐蚀缺陷钻杆,其剩余抗拉强度受腐蚀深度的影响最大,且随着腐蚀半径的增大而增大。与该有限元法相比,依据现行石油行业标准计算所得的钻杆剩余抗拉强度较大,按此强度设计的钻杆存在一定安全风险,因此,设计中应充分考虑不同腐蚀形态的影响。

Treatment of stellate ganglion block in diseases:Its role and application prospect

The stellate ganglion(SG),as a type of sympathetic ganglion,consists of the sixth and seventh cervical vertebrae and the first thoracic sympathetic ganglia.SG block(SGB)is a minimally invasive injection that aims to inject low-concentration local anesthetics to induce a broad sympathetic blocking effect near the SG.There have been no changes and progress in the clinical application of SGB since the 1830s due to several potential risks,including hematoma from blood vessel injury,hoarseness from recurrent laryngeal nerve injury,and cardiopulmonary arrest.The feasibility and safety of SGB have greatly improved since the appearance of ultrasound-guided SGB.In recent years,SGB has been widely applied in the field of non-anesthesiology sedation,with significant therapeutic effects on pain,immunological diseases,somnipathy,psychological disorders,arrhythmias,and endocrine diseases.The present study reviews the present application of SGB in clinical practice.

Three-dimensional isotropic microfabrication in glass using spatiotemporal focusing of high-repetition-rate femtosecond laser pulses

To improve the processing efficiency and extend the tuning range of 3D isotropic fabrication,we apply the simultaneous spatiotemporal focusing(SSTF)technique to a high-repetition-rate femtosecond(fs)fiber laser system.In the SSTF scheme,we propose a pulse compensation scheme for the fiber laser with a narrow spectral bandwidth by building an extra-cavity pulse stretcher.We further demonstrate truly 3D isotropic microfabrication in photosensitive glass with a tunable resolution ranging from 8μm to 22μm using the SSTF of fs laser pulses.Moreover,we systematically investigate the influences of pulse energy,writing speed,processing depth,and spherical aberration on the fabrication resolution.As a proof-of-concept demonstration,the SSTF scheme was further employed for the fs laser-assisted etching of complicated glass microfluidic structures with 3D uniform sizes.The developed technique can be extended to many applications such as advanced photonics,3D biomimetic printing,micro-electromechanical systems,and lab-on-a-chips.

Effects of time-delayed vibration absorber on bandwidth of beam for low broadband vibration suppression

The effects of time-delayed vibration absorber(TDVA) on the dynamic characteristics of a flexible beam are investigated. First, the vibration suppression effect of a single TDVA on a continuous beam is studied. The first optimization criterion is given,and the results show that the introduction of time-delayed feedback control(TDFC) is beneficial to improving the vibration suppression at the anti-resonance band. When a single TDVA is used, the anti-resonance is located at a specific frequency by the optimum design of TDFC parameters. Then, in order to obtain low-frequency and broad bands for vibration suppression, multiple TDVAs are uniformly distributed on a continuous beam,and the relationship between the dynamic responses and the TDFC parameters is investigated. The obtained relationship shows that the TDVA has a significant regulatory effect on the vibration behavior of the continuous beam. The effects of the number of TDVAs and the nonlinearity on the bandgap variation are discussed. As the multiple TDVAs are applied, according to the different requirements on the location and bandwidth of the effective vibration suppression band, the optimization criteria for the TDFC parameters are given, which provides guidance for the applications of TDVAs in practical projects such as bridge and aerospace.

Screening effect of plasma flow on the resonant magnetic perturbation penetration in tokamaks based on two-fluid model

Numerical simulation on the resonant magnetic perturbation penetration is carried out by the newly-updated initial value code MDC(MHD@Dalian Code).Based on a set of two-fluid fourfield equations,the bootstrap current,parallel,and perpendicular transport effects are included appropriately.Taking into account the bootstrap current,a mode penetration-like phenomenon is found,which is essentially different from the classical tearing mode model.To reveal the influence of the plasma flow on the mode penetration process,E×B drift flow and diamagnetic drift flow are separately applied to compare their effects.Numerical results show that a sufficiently large diamagnetic drift flow can drive a strong stabilizing effect on the neoclassical tearing mode.Furthermore,an oscillation phenomenon of island width is discovered.By analyzing it in depth,it is found that this oscillation phenomenon is due to the negative feedback regulation of pressure on the magnetic island.This physical mechanism is verified again by key parameter scanning.

Outsourced Privacy-Preserving kNN Classifier Model Based on Multi-Key Homomorphic Encryption

Outsourcing the k-Nearest Neighbor(kNN)classifier to the cloud is useful,yet it will lead to serious privacy leakage due to sensitive outsourced data and models.In this paper,we design,implement and evaluate a new system employing an outsourced privacy-preserving kNN Classifier Model based on Multi-Key Homomorphic Encryption(kNNCM-MKHE).We firstly propose a security protocol based on Multi-key Brakerski-Gentry-Vaikuntanathan(BGV)for collaborative evaluation of the kNN classifier provided by multiple model owners.Analyze the operations of kNN and extract basic operations,such as addition,multiplication,and comparison.It supports the computation of encrypted data with different public keys.At the same time,we further design a new scheme that outsources evaluation works to a third-party evaluator who should not have access to the models and data.In the evaluation process,each model owner encrypts the model and uploads the encrypted models to the evaluator.After receiving encrypted the kNN classifier and the user’s inputs,the evaluator calculated the aggregated results.The evaluator will perform a secure computing protocol to aggregate the number of each class label.Then,it sends the class labels with their associated counts to the user.Each model owner and user encrypt the result together.No information will be disclosed to the evaluator.The experimental results show that our new system can securely allow multiple model owners to delegate the evaluation of kNN classifier.

Study on Real-Time Heart Rate Detection Based on Multi-People

Heart rate is an important vital characteristic which indicates physical and mental health status.Typically heart rate measurement instruments require direct contact with the skin which is time-consuming and costly.Therefore,the study of non-contact heart rate measurement methods is of great importance.Based on the principles of photoelectric volumetric tracing,we use a computer device and camera to capture facial images,accurately detect face regions,and to detect multiple facial images using a multi-target tracking algorithm.Then after the regional segmentation of the facial image,the signal acquisition of the region of interest is further resolved.Finally,frequency detection of the collected Photo-plethysmography(PPG)and Electrocardiography(ECG)signals is completed with peak detection,Fourier analysis,and a Waveletfilter.The experimental results show that the subject’s heart rate can be detected quickly and accurately even when monitoring multiple facial targets simultaneously.

Impact of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on the mortality in sepsis: A meta-analysis

BACKGROUND The effect of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin receptor blockers(ARBs)on the mortality of patients with sepsis is not well characterized.AIM To elucidate the association between prior ACEI or ARB exposure and mortality in sepsis.METHODS The PubMed,EMBASE,Web of Science,and Cochrane Library databases were searched for all studies of premorbid ACEI or ARB use and sepsis mortality until November 302019.Two reviewers independently assessed,selected,and ab-stracted data from studies reporting ACEIs or ARBs,sepsis,and mortality.The primary extracted data consisted of premorbid ACEI or ARB exposure,mortality,and general patient data.Two reviewers independently assessed the risk of bias and quality of evidence.RESULTS A total of six studies comprising 281238 patients with sepsis,including 49799 cases with premorbid ACEI or ARB exposure were eligible for analysis.Pre-morbid ACEIs or ARBs exposure decreased the 30-d mortality in patients with sepsis.Moreover,the use of ACEIs or ARBs was associated with approximately a 6%decreased risk of 30-d mortality.CONCLUSION The results of this systematic review suggest that ACEI or ARB exposure prior to sepsis may be associated with reduced mortality.Further high-quality cohort studies and molecular mechanism experiments are required to confirm our results.

页岩膨胀应变及固井质量对套管变形的影响研究

威荣地区页岩气井套管变形问题突出,但目前引发该区域套管变形的机理尚不明确。该文基于页岩理化性质,分析了页岩膨胀应变对套管应力的影响,研究了考虑页岩膨胀应变条件下的固井质量与套管变形的关系。研究表明:威荣地区页岩呈硬脆性,力学强度高,水化后强度变化不明显;页岩膨胀应变及固井质量的综合作用对套管应力有明显影响,当水泥环缺失及存在微环隙时,能为膨胀应力提供足够的释放空间,降低套管应力,当膨胀应力不能被充分释放时,需尽量保证井筒组合体结构的完整性。高密度射孔对膨胀应力的释放具有积极效果,在合理的射孔参数条件下开展高密度射孔作业是预防套管变形的有效措施之一。该研究为同类页岩气藏套管变形机理研究提供了参考。

核壳结构p-n异质结复合光催化剂BiFeO_3@TiO_2的制备及其在可见光催化降解中的应用（英文）

化石燃料的迅速消耗导致环境污染与能源危机日益加剧.太阳能高效利用与转换是解决该难题的有效途径之一.在众多光催化剂中,TiO_2因其高催化活性、高稳定性、低毒性以及低成本等优势而普遍受到关注,但TiO_2存在着带隙过宽而无法利用可见光的缺陷,严重制约了其在光催化方向的实际应用.核壳型复合纳米材料具有较大的比表面积、较高的光吸收能力以及所吸附的污染物分子易于从吸附面扩散到光致降解面等特点,而表现出较强的有机污染物吸附性能以及良好的光催化活性.以磁体材料为核将TiO_2包覆于磁体表面,可以制备具有磁分离特性的磁载光催化剂.而铁酸铋作为一种在室温下同时具有铁电性和铁磁性的钙钛矿型材料,由于其较窄的带宽(2.1 e V)在可见光催化氧化方面也受到了极大的关注.本文首先通过柠檬酸自燃烧法制备了可磁性分离的BiFeO_3粉体,再以水解沉淀法将TiO_2包裹在BiFeO_3前驱体上形成了不同质量比(1:1,1:2,2:1)的核壳结构的BiFeO_3@TiO_2复合粉体,并以甲基紫为例,对其在紫外光和可见光照射下的光催化性能分别展开了研究.结果表明,BiFeO_3@TiO_2复合粉体的光催化性能较单独的BiFeO_3或TiO_2均有所提升.其中质量比为1:1的BiFeO_3@TiO_2复合粉体(TiO_2壳层厚度为50–100 nm)展现出最强的光催化氧化活性,且在可见光下有更高的光催化效率.经表征分析,该复合粉体光催化性能高的原因可能归结于BiFeO_3与TiO_2两者之间形成了p-n异质结界面,有效地提高了电荷载流子的传输分离效率,同时BiFeO_3较窄的禁带宽度拓展了纳米TiO_2的光谱吸收范围,增强其光吸收能力.光电化学Mott-Schottky测试结果进一步证实:BiFeO_3粉体在与TiO_2复合之后,其电荷载流子传输与供体密度均有显著提升.自由基猝灭实验表明,在甲基紫光催化降解中起主要作用的为羟基自由基与光生电子,并结合能带理论与自建电场理论对降解机理进行了阐述.进一步研究表明,甲基紫降解效果最优条件为:复合粉体的投加量为1 g/L,甲基紫初始浓度为10 mg/L,初始pH为5.另外,质量比1:1的BiFeO_3@TiO_2对甲基橙和刚果红染料废水也具有较好的降解效果,表现出良好的工业应用前景.

热性惊厥患儿血清中表观遗传标志物的表达及临床意义

目的分析热性惊厥(FS)患儿血清中DNA甲基转移酶1、3A、3B(DNMT1、DNMT3A、DNMT3B)、组蛋白甲基转移酶EZH2(EZH2)及组蛋白去乙酰化酶4(HDAC4)的变化情况,探讨其在FS疾病中的临床意义。方法选取60例FS患儿,其中包括30例单纯型FS(SFS)和30例复杂型FS(CFS)。另选取30例正常健康体检儿童为正常对照组,采用实时荧光定量聚合酶链反应(q RT-PCR)和酶联免疫吸附实验(ELISA)检测比较3组间3种酶基因和蛋白之间的表达水平变化。结果 (1)SFS组和CFS组DNMT1、DNMT3A、DNMT3B、EZH2、HDAC4基因表达均高于正常对照组,差异有统计学意义(P<0.05);SFS组与CFS组之间比较,差异无统计学意义(P>0.05)。(2)SFS组和CFS组DNMT1、DNMT3A、DNMT3B、EZH2、HDAC4蛋白表达水平均高于正常对照组,差异有统计学意义(P<0.05);SFS组与CFS组之间比较,差异无统计学意义(P>0.05)。结论SFS和CFS组患儿血清中DNMT1、DNMT3A、DNMT3B、EZH2和HDAC4基因及蛋白水平均呈现高表达模式,提示表观遗传修饰在FS中的发生发展过程中发挥着重要作用,为深入研究FS的致病机制及防治FS提供了实验依据。