Objective:To study the effect of swimming training on the nerve injury, nerve cytokine expression and related signaling pathway in rats with cerebral infarction.Methods: SD male rats were selected as the experimental ...Objective:To study the effect of swimming training on the nerve injury, nerve cytokine expression and related signaling pathway in rats with cerebral infarction.Methods: SD male rats were selected as the experimental animals and randomly divided into control group, cerebral infarction group and intervention group, control group received sham operation, cerebral infarction group were made into cerebral infarction models through suture method, and intervention group were made into cerebral infarction models through suture method and received swimming training. 21 d after intervention, serum was collected to determine the contents of nerve injury indexes and nerve cytokines, and brain tissue was collected to determine the expression levels of nerve apoptosis molecules, nerve cytokines and signaling pathway molecules.Results: Brain tissue CytC, Bax, Caspase-3, TLR4, NF-kB, MyD88, JAK2 and STAT3 contents as well as serum NSE and S100B contents of cerebral infarction group were significantly higher than those of control group while NGF, BDNF and NT-3 contents in the brain tissue and serum were significantly lower than those of control group;brain tissue CytC, Bax, Caspase-3, TLR4, NF-kB, MyD88, JAK2 and STAT3 contents as well as serum NSE and S100B contents of intervention group were significantly lower than those of cerebral infarction group while NGF, BDNF and NT-3 contents in the brain tissue and serum were significantly higher than those of cerebral infarction group.Conclusion:Swimming training can improve the neural function of rats with cerebral infarction, and inhibiting neuron apoptosis and improving neuron nutrition are the molecular mechanisms for swimming training to promote the neural functional recovery.展开更多
文摘Objective:To study the effect of swimming training on the nerve injury, nerve cytokine expression and related signaling pathway in rats with cerebral infarction.Methods: SD male rats were selected as the experimental animals and randomly divided into control group, cerebral infarction group and intervention group, control group received sham operation, cerebral infarction group were made into cerebral infarction models through suture method, and intervention group were made into cerebral infarction models through suture method and received swimming training. 21 d after intervention, serum was collected to determine the contents of nerve injury indexes and nerve cytokines, and brain tissue was collected to determine the expression levels of nerve apoptosis molecules, nerve cytokines and signaling pathway molecules.Results: Brain tissue CytC, Bax, Caspase-3, TLR4, NF-kB, MyD88, JAK2 and STAT3 contents as well as serum NSE and S100B contents of cerebral infarction group were significantly higher than those of control group while NGF, BDNF and NT-3 contents in the brain tissue and serum were significantly lower than those of control group;brain tissue CytC, Bax, Caspase-3, TLR4, NF-kB, MyD88, JAK2 and STAT3 contents as well as serum NSE and S100B contents of intervention group were significantly lower than those of cerebral infarction group while NGF, BDNF and NT-3 contents in the brain tissue and serum were significantly higher than those of cerebral infarction group.Conclusion:Swimming training can improve the neural function of rats with cerebral infarction, and inhibiting neuron apoptosis and improving neuron nutrition are the molecular mechanisms for swimming training to promote the neural functional recovery.
