Clinical observation of electroacupuncture"Tongmin Point"combined with heat-sensitive moxibustion on knee osteoarthritis and its influence on blood lipid level and ADAMTS-4

Objective:To observe the clinical effect of electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level,polyprotein polysaccharide enzyme-4(a disintegrin and metalloprotease with thrombospondin motifs,ADAMTS-4,matrix metalloproteinase-3(matrix metalloproteinase-3,);and MMPs-3)Impact.Methods:80 patients were randomly divided into two groups,40 cases per group,Treatment and control groups,The treatment group was given electroacupuncture combined with heat-sensitive moxibustion,Six times a week,Continuous treatment for 4 weeks;The control group was given intraarticular sodium hyaluronate,Once a week,continuous treatment for 4 weeks.Results:During the treatment period,Visual analogue scale visual analogue scale,VAS)show a downward trend,Intra-group comparisons,Differences were statistically significant(P<0.05);After 2 weeks of treatment,4 weeks of treatment and 2 weeks of follow-up,All the scores in the treatment group were lower than those in the control group(P<0.05).After treatment in two groups(The Western Ontario and Mc Master Universities Osteoarthritis Index,)of osteoarthritis index,University of Western Ontario WOMAC)The scores of each item decreased significantly,treatment group was better than the control group(P<0.05).After four weeks of treatment,(Total cholesterol,)Total cholesterol TC,triglycerides(Triglyceride,);and TG,LDL(Low density lipoprotein,);and LDL-C)A decrease in content,High density lipoprotein High density lipoprotein,HDL-C)Increased content,and the improvement was better than that of the control group(P<0.05).After treatment,the ADAMTS-4,MMPs-3 content decreased,Intergroup comparisons,Differences were statistically significant(P<0.05);The effective rate in the treatment group was 87.5%,The control rate was 60%,treatment group was more effective(P<0.05).Conclusions:Electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion can obviously improve the symptoms of knee osteoarthritis patients,Regulate blood lipids,High security,It is worth popularizing in clinic.

Two-dimensional MoS_(2)/diamond based heterojunctions for excellent optoelectronic devices:current situation and new perspectives

Two-dimensional(2D)semiconductor molybdenum disulfide(MoS_(2))can be used as n-channel and is considered as a key candidate material to advance the promising development of optoelectronic device.The high thermal conductivity,breakdown voltage,carrier mobility,and high saturation velocity of diamond offer the possibility of making it high-frequency device material in hightemperature and high-power fields.The addition of 2D MoS_(2)nanolayers and nanosheets to diamond thin film to form heterojunction can improve the carrier transport performance of the optoelectronic device in harsh environments.In this perspective,the prospects of 2D MoS_(2)/diamond heterojunction for challenges and new designs of optoelectronic applications are discussed,including photodetectors,memories,transistors,light emission diodes,and electron field emission devices to further explore the development of 2D material device field in complex environments.