RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-m...RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-methyladenosine(m6 A)is the most abundant and best-characterized internal modification in mRNAs(Boccaletto et al.,2018).Benefit from the fast development of innovative technologies,the prevalence of m6 A has been reported and confirmed repeatedly in diverse organisms.Recent studies reveal that aberrant m6 A modification is associated with various disease progressions such as carcinogenesis and tumorigenesis by disturbing the expression of oncogenes and tumor suppressor genes(Tuncel and Kalkan,2019;Zhao et al.,2020).The m6 A methyltransferase METTL3 is found to be overexpressed in acute myeloid leukemia(AML)(Barbieri et al.,2017;Vu et al.,2017),which consequently elevates the m6 A level of B cell lymphoma 2(BCL2)transcript and promotes the translation effi-ciency。展开更多
基金the Ministry of Science and Technology of China(National Science and Technology Major Project,2019YFA0802203,2018YFA0109100)National Natural Science Foundation of China(31922015,31870808,91753129)+1 种基金Natural Science Foundation of Guangdong Province(2018B030306044,2019A1515110099)China Postdoctoral Science Foundation(2020M672949 and 2019M653164).
文摘RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-methyladenosine(m6 A)is the most abundant and best-characterized internal modification in mRNAs(Boccaletto et al.,2018).Benefit from the fast development of innovative technologies,the prevalence of m6 A has been reported and confirmed repeatedly in diverse organisms.Recent studies reveal that aberrant m6 A modification is associated with various disease progressions such as carcinogenesis and tumorigenesis by disturbing the expression of oncogenes and tumor suppressor genes(Tuncel and Kalkan,2019;Zhao et al.,2020).The m6 A methyltransferase METTL3 is found to be overexpressed in acute myeloid leukemia(AML)(Barbieri et al.,2017;Vu et al.,2017),which consequently elevates the m6 A level of B cell lymphoma 2(BCL2)transcript and promotes the translation effi-ciency。
