AIM: To investigate the association between true insulin and proinsulin and clustering of cardiovascular risk factors.METHODS: Based on the random stratified sampling principles, 1196 Chinese people (533 males and 663...AIM: To investigate the association between true insulin and proinsulin and clustering of cardiovascular risk factors.METHODS: Based on the random stratified sampling principles, 1196 Chinese people (533 males and 663 females,aged 35-59 years with an average age of 46.69 years) were recruited. Biotin-avidin based double monoclonal antibody ELISA method was used to detect the true insulin and proinsulin, and a risk factor score was set to evaluate individuals according to the number of risk factors.RESULTS: The median (quartile range) of true insulin and proinsulin was 4.91 mIu/L (3.01-7.09 mIu/L) and 3.49 pmol/L (2.14-5.68 pmol/L) respectively, and the true insulin level of female subjects was significantly higher than that of male subjects (P = 0.000), but the level of proinsulin displayed no significant difference between males and females (P = 0.566). The results of covariate ANOVA after age and sex were controlled showed that subjects with any of the risk factors had a significantly higher true insulin level (P = 0.002 for hypercholesterolemia, P = 0.021 for high low-density lipoprotein cholesterol, P = 0.003 for low high-density lipoprotein cholesterol, and P = 0.000 for other risk factors) and proinsulin level (P = 0.001 for low high-density lipoprotein cholesterol, and P = 0.000 for other risk factors)than those with no risk factors. Furthermore, subjects with higher risk factor scores had a higher true insulin and proinsulin level than those with lower risk factor scores (P = 0.000). The multiple linear regression models showed that true insulin and proinsulin were significantly related to cardiovascular risk factor scores respectively (P = 0.000).CONCLUSION: True insulin and proinsulin are significantly associated with the clustering of cardiovascular risk factors.展开更多
Most existing secret sharing schemes are constructed to realize generalaccess structure, which is defined in terms of authorized groups of participants, and is unable tobe applied directly to the design of intrusion t...Most existing secret sharing schemes are constructed to realize generalaccess structure, which is defined in terms of authorized groups of participants, and is unable tobe applied directly to the design of intrusion tolerant system, which often concerns corruptiblegroups of participants instead of authorized ones. Instead, the generalized adversary structure,which specifies the corruptible subsets of participants, can be determined directly by exploit ofthe system setting and the attributes of all participants. In this paper an efficient secret sharingscheme realizing generalized adversary structure is proposed, and it is proved that the schemesatisfies both properties of the secret sharing scheme, i.e., the reconstruction property and theperfect property. The main features of this scheme are that it performs modular additions andsubtractions only, and each share appears in multiple share sets and is thus replicated. The formeris an advantage in terms of computational complexity, and the latter is an advantage when recoveryof some corrupted participants is necessary. So our scheme can achieve lower computation cost andhigher availability. Some reduction on the scheme is also done finally, based on an equivalencerelation defined over adversary structure. Analysis shows that reduced scheme still preserves theproperties of the original one.展开更多
文摘AIM: To investigate the association between true insulin and proinsulin and clustering of cardiovascular risk factors.METHODS: Based on the random stratified sampling principles, 1196 Chinese people (533 males and 663 females,aged 35-59 years with an average age of 46.69 years) were recruited. Biotin-avidin based double monoclonal antibody ELISA method was used to detect the true insulin and proinsulin, and a risk factor score was set to evaluate individuals according to the number of risk factors.RESULTS: The median (quartile range) of true insulin and proinsulin was 4.91 mIu/L (3.01-7.09 mIu/L) and 3.49 pmol/L (2.14-5.68 pmol/L) respectively, and the true insulin level of female subjects was significantly higher than that of male subjects (P = 0.000), but the level of proinsulin displayed no significant difference between males and females (P = 0.566). The results of covariate ANOVA after age and sex were controlled showed that subjects with any of the risk factors had a significantly higher true insulin level (P = 0.002 for hypercholesterolemia, P = 0.021 for high low-density lipoprotein cholesterol, P = 0.003 for low high-density lipoprotein cholesterol, and P = 0.000 for other risk factors) and proinsulin level (P = 0.001 for low high-density lipoprotein cholesterol, and P = 0.000 for other risk factors)than those with no risk factors. Furthermore, subjects with higher risk factor scores had a higher true insulin and proinsulin level than those with lower risk factor scores (P = 0.000). The multiple linear regression models showed that true insulin and proinsulin were significantly related to cardiovascular risk factor scores respectively (P = 0.000).CONCLUSION: True insulin and proinsulin are significantly associated with the clustering of cardiovascular risk factors.
文摘Most existing secret sharing schemes are constructed to realize generalaccess structure, which is defined in terms of authorized groups of participants, and is unable tobe applied directly to the design of intrusion tolerant system, which often concerns corruptiblegroups of participants instead of authorized ones. Instead, the generalized adversary structure,which specifies the corruptible subsets of participants, can be determined directly by exploit ofthe system setting and the attributes of all participants. In this paper an efficient secret sharingscheme realizing generalized adversary structure is proposed, and it is proved that the schemesatisfies both properties of the secret sharing scheme, i.e., the reconstruction property and theperfect property. The main features of this scheme are that it performs modular additions andsubtractions only, and each share appears in multiple share sets and is thus replicated. The formeris an advantage in terms of computational complexity, and the latter is an advantage when recoveryof some corrupted participants is necessary. So our scheme can achieve lower computation cost andhigher availability. Some reduction on the scheme is also done finally, based on an equivalencerelation defined over adversary structure. Analysis shows that reduced scheme still preserves theproperties of the original one.
