The TP53, a transcriptional regulator and tumor suppressor, is functionally important in spermatogenesis. MDM2 is a key regulator of the p53 pathway and modulates p53 activity. Both proteins have been functionally lin...The TP53, a transcriptional regulator and tumor suppressor, is functionally important in spermatogenesis. MDM2 is a key regulator of the p53 pathway and modulates p53 activity. Both proteins have been functionally linked to germ cell apoptosis, which may affect human infertility, but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility. Thus, this study was designed to test whether three previously described polymorphisms 72Arg〉Pro （rs1042522） and the Ex2＋ 19C〉T （rs2287498） in TP53, and the 5＇ untranslated region （5＇ UTR） 309T〉G （rs937283） in MDM2, are associated with idiopathic male infertility in a Chinese population. The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study, including 580 infertile patients and 580 fertile controls. Our analyses revealed that TP53 Ex2-1-19C〉T and MDM2 309T〉G polymorphisms are associated with male infertility. Furthermore, we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male infertility （Pinteraction--O-055）- In summary, this study found preliminary evidence, demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.展开更多
An algorithm based on hyperspectral infrared cloudy radiative transfer model (HIRTM) is introduced and a simulation method for infrared image of the generation geostationary meteorological satellite is proposed. Based...An algorithm based on hyperspectral infrared cloudy radiative transfer model (HIRTM) is introduced and a simulation method for infrared image of the generation geostationary meteorological satellite is proposed. Based on the parameters from weather research and forecast (WRF), such as the water content, atmospheric temperature, and humidity profile, the simulation data for the advanced Himawari imager (AHI) infrared radiative (IR) channels of Himawari-8 are obtained. Simulated results based on HIRTM agree well with the observed data. Further, the movement, development, and change of the cloud are well predicated. And the simulation of IR cloud image for the weather forecast has been obtained. This paper provides an improved method for evaluation and improvement of regional numerical model for weather forecast.展开更多
文摘The TP53, a transcriptional regulator and tumor suppressor, is functionally important in spermatogenesis. MDM2 is a key regulator of the p53 pathway and modulates p53 activity. Both proteins have been functionally linked to germ cell apoptosis, which may affect human infertility, but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility. Thus, this study was designed to test whether three previously described polymorphisms 72Arg〉Pro （rs1042522） and the Ex2＋ 19C〉T （rs2287498） in TP53, and the 5＇ untranslated region （5＇ UTR） 309T〉G （rs937283） in MDM2, are associated with idiopathic male infertility in a Chinese population. The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study, including 580 infertile patients and 580 fertile controls. Our analyses revealed that TP53 Ex2-1-19C〉T and MDM2 309T〉G polymorphisms are associated with male infertility. Furthermore, we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male infertility （Pinteraction--O-055）- In summary, this study found preliminary evidence, demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.
基金supported by the Climate Change Special Project under Grant No.CCSF201834
文摘An algorithm based on hyperspectral infrared cloudy radiative transfer model (HIRTM) is introduced and a simulation method for infrared image of the generation geostationary meteorological satellite is proposed. Based on the parameters from weather research and forecast (WRF), such as the water content, atmospheric temperature, and humidity profile, the simulation data for the advanced Himawari imager (AHI) infrared radiative (IR) channels of Himawari-8 are obtained. Simulated results based on HIRTM agree well with the observed data. Further, the movement, development, and change of the cloud are well predicated. And the simulation of IR cloud image for the weather forecast has been obtained. This paper provides an improved method for evaluation and improvement of regional numerical model for weather forecast.
