Hepatic actinomycosis:Report of one case and analysis of 32 previously reported cases

Hepatic actinomycosis is rare,with few published cases.There are no characteristic clinical manifestations,and computed tomography(CT)shows mainly low-density images,making clinical diagnosis difficult,and leading to frequent misdiagnosis as primary liver cancer,metastatic liver cancer or liver abscess.Diagnosis normally requires examination of both the aetiology and pathology.This article reports one male patient aged 55 who was hospitalized because of repeated upper abdominal pain for more than 2 mo.He exhibited no chills,fever or yellow staining of the skin and sclera,and examination revealed no positive signs.The routine blood results were:haemoglobin 110 g/L,normal numbers of leukocytes and neutral leukocytes,serum albumin 32g/L,negative serum hepatitis B markers and hepatitis C antibodies,normal tumour markers(alpha-fetoproteinand carcinoembryonic antigen).An abdominal CT scan revealed an 11.2 cm×5.8 cm×7.4 cm mass with an unclear edge in the left liver lobe.The patient was diagnosed as having primary liver cancer,and left lobe resection was performed.The postoperative pathological examination found multifocal actinomycetes in the hepatic parenchyma,which was accompanied by chronic suppurative inflammation.A focal abscess had formed,and large doses of sodium penicillin were administered postoperatively as anti-infective therapy.This article also reviews 32 cases reported in the English literature,with the aim of determining the clinical features and treatment characteristics of this disease,and providing a reference for its diagnosis and treatment.

Design and Synthesis of Sulfanilamide Aminophosphonates as Novel Antibacterial Agents towards Escherichia coli

The limit ability of traditional antibiotics to treat drug resistant bacteria calls for new therapeutic alter natives.A class of unique sul-fanilamide aminophosphonates as new potential agents against microbes was synthesized by one-pot three-component reaction.

Design,synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents

A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy.