Research progress of traditional Chinese medicine rehabilitation of chronic heart failure

In recent years,the rehabilitation of heart disease in China has developed rapidly.Five types of cardiac rehabilitation prescriptions and numerous consensus on cardiac disease rehabilitation have been put forward,which further promote and standardize the development of cardiac rehabilitation in our country.Traditional Chinese medicine has a long history and is safe and effective in rehabilitation treatment.Combining with the research of modern cardiac rehabilitation medicine will be the inevitable choice for the development of cardiac rehabilitation medicine in China in the future.This article summarizes the progress of the application of modern Chinese medicine in the rehabilitation treatment of chronic heart failure,in order to provide reference for the clinical research and application of traditional Chinese medicine in the rehabilitation of chronic heart failure and to give full play to the advantages of modern traditional Chinese medicine rehabilitation treatment.

Research progress on the application of traditional Chinese medicine in the draining water method of chronic heart failure

Chronic heart failure(CHF)is a public health problem that seriously affects the quality of life of patients with poor prognosis.Western medicine has been mature in the treatment of CHF,but it still has some limitations and adverse reactions in improving the clinical symptoms of CHF.TCM has a long history of understanding of CHF,and in recent years,TCM has summarized and developed the experience of predecessors in the treatment of CHF,In particular,diuretic therapy,combined with Warming Yang,tonifying Qi,promoting blood circulation and removing blood stasis,has achieved good curative effect in treating CHF.When combined with basic treatment of Western medicine,it can reduce the adverse reactions of Western medicine.This review is to summarize.

A summary of research on benefiting Qi and activating blood to regulate mitophagy to prevent and treat ischemic heart disease

Ischemic heart disease has the characteristics of high morbidity and high mortality, which seriously endangers people's health. Mitophagy can selectively remove damaged organelles, and has a role in maintaining the homeostasis of myocardial cells and protecting ischemic myocardium. Significance. More and more studies have found that traditional Chinese medicine can improve ischemic damage of cardiomyocytes by regulating mitochondrial function and autophagy. Using mitochondria as the target of traditional Chinese medicine in cardiomyocytes to explore the treatment of ischemic Effective measures for heart disease have become a hotspot for related Chinese medicine workers. Based on the above background, this article outlines the main regulatory pathways of mitochondrial autophagy, and reviews related researches on traditional Chinese medicine of benefiting qi and activating blood and mitophagy in this field.

Whole exome sequencing and trio analysis to broaden the variant spectrum of genes in idiopathic hypogonadotropic hypogonadism

Dozens of genes are associated with idiopathic hypogonadotropic hypogonadism(IHH)and an oligogenic etiology has been suggested.However,the associated genes may account for only approximately 50%cases.In addition,a genomic systematic pedigree analysis is still lacking.Here,we conducted whole exome sequencing(WES)on 18 unrelated men affected by IHH and their corresponding parents.Notably,one reported and 10 novel variants in eight known IHH causative genes(AXL,CCDC141,CHD7,DMXL2,FGFR1,PNPLA6,POLR3A,and PR0KR2),nine variants in nine recently reported candidate genes(DCAF17,DCC,EGF,IGSF10,NOTCH1,PDE3A,RELN,SLIT2,and TRAPPC9),and four variants in four novel candidate genes for IHH(CCDC88C,CDON,GADL1,and SPRED3)were identified in 77.8%(14/18)of IHH cases.Among them,eight(8/18,44.4%)cases carried more than one variant in IHH-related genes,supporting the oligogenic model.Interestingly,we found that those variants tended to be maternally inherited(maternal with n=17 vs paternal with n=7;P=0.028).Our further retrospective investigation of published reports replicated the maternal bias(maternal with n=46 i^s paternal with n=28;P=0.024).Our study extended a variant spectrum for IHH and provided the first evidence that women are probably more tolerant to variants of IHH-related genes than men.