The direct excitation of dihydroquinazolinone(DHQ)anions by visible light has been demonstrated by photophysical experiments.The excited-state DHQ anion serves as both a potent reductant and a radical precursor in a r...The direct excitation of dihydroquinazolinone(DHQ)anions by visible light has been demonstrated by photophysical experiments.The excited-state DHQ anion serves as both a potent reductant and a radical precursor in a redox neutral radical cascade,circumventing the use of an external photoredox catalyst.Various gem-difluoroalkyl radicals(CF_(2)H and CF_(2)R)are produced from the excited-state DHQ anions,leading to the first example of intermolecular 1,2-difluoroalkylarylation(CF_(2)H-and CF_(2)R-arylation)of alkenes in overall redox-neutral manner.Similarly,1,2-difluoroalkylamination of styrenes has also been realized,offering a practical pathway for the preparation of diverseβ-CF_(2)H amines.This general and efficient strategy for the generation of CF_(2)H and CF_(2)R radicals exhibits great potential for applications in drug discovery.展开更多
基金the National Natural Science Foundation of China(grant nos.22101176 and 22137003).
文摘The direct excitation of dihydroquinazolinone(DHQ)anions by visible light has been demonstrated by photophysical experiments.The excited-state DHQ anion serves as both a potent reductant and a radical precursor in a redox neutral radical cascade,circumventing the use of an external photoredox catalyst.Various gem-difluoroalkyl radicals(CF_(2)H and CF_(2)R)are produced from the excited-state DHQ anions,leading to the first example of intermolecular 1,2-difluoroalkylarylation(CF_(2)H-and CF_(2)R-arylation)of alkenes in overall redox-neutral manner.Similarly,1,2-difluoroalkylamination of styrenes has also been realized,offering a practical pathway for the preparation of diverseβ-CF_(2)H amines.This general and efficient strategy for the generation of CF_(2)H and CF_(2)R radicals exhibits great potential for applications in drug discovery.
