DEAR EDITOR,The rise of the plasmid-encoded colistin resistance gene mcr-1 is a major concern globally.Here,during a routine surveillance,an unexpectedly high prevalence of Escherichia coli with reduced susceptibility...DEAR EDITOR,The rise of the plasmid-encoded colistin resistance gene mcr-1 is a major concern globally.Here,during a routine surveillance,an unexpectedly high prevalence of Escherichia coli with reduced susceptibility to colistin (69.9%) was observed in a Chinese broiler farm.Fifty-three (63.9%) E.coli isolates were positive for mcr-1.All identified mcr-1-positive E.展开更多
The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin(SCARLET)trial has many defects,and thus cannot be the terminator of recombinant thrombomodulin(rTM).On the contrary,it provides sufficient evidence for furth...The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin(SCARLET)trial has many defects,and thus cannot be the terminator of recombinant thrombomodulin(rTM).On the contrary,it provides sufficient evidence for further research.Based on analysis focusing on the failure of SCARLET and several previous anticoagulant studies,it is most important for new studies to grasp the following two points:(1)The enrolled cases should have sufficient disease severity and a clear standard for disseminated intravascular coagulation;(2)Heparin should not be used in combination with the investigated drugs.Multiple post-hoc analyses show that no combination of heparin will not increase the risk of thromboembolism.In fact,the combination of heparin can mask the true efficacy of the investigated drug.Due to the complexity of sepsis treatment and the limitations of clinical studies,the results of all treatment studies should be repeatedly verified,rather than be determined at one stroke.Some research conclusions contrary to disease physiology,pharmacology and clinical practice may be deceptive,and should be cautious rather than be simply accepted.On the other hand,the dissenting voices in the"consensus"scene are often well discussed by the authors and should be highly valued.展开更多
A 19-year-old male patient who suffered from sudden and repeated multiple organ dysfunction syndrome one month after the bar removal procedure of Nuss surgery for pectus excavatum was admitted to our department.With o...A 19-year-old male patient who suffered from sudden and repeated multiple organ dysfunction syndrome one month after the bar removal procedure of Nuss surgery for pectus excavatum was admitted to our department.With organ function supportive treatment,the etiology was finally identified to be a bone spur located at the inner border of the left costa due to repeated friction between the implanted steel bar and the rib,which damaged the heart repeatedly and induced the consequent acute cardiac tamponade.After operation,the patient was successfully managed and discharged.Follow-ups till three years indicated a good recovery.展开更多
基金supported in part by the National Natural Science Foundation of China(31830099,31902322)International Science and Technology Cooperation Project of Xinjiang Production and Construction Corps(XPCC)(2019BC004)+1 种基金Guangdong Special Support Program Innovation Team(2019BT02N054)Innovation Team Project of Guangdong University(2019KCXTD001)。
文摘DEAR EDITOR,The rise of the plasmid-encoded colistin resistance gene mcr-1 is a major concern globally.Here,during a routine surveillance,an unexpectedly high prevalence of Escherichia coli with reduced susceptibility to colistin (69.9%) was observed in a Chinese broiler farm.Fifty-three (63.9%) E.coli isolates were positive for mcr-1.All identified mcr-1-positive E.
文摘The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin(SCARLET)trial has many defects,and thus cannot be the terminator of recombinant thrombomodulin(rTM).On the contrary,it provides sufficient evidence for further research.Based on analysis focusing on the failure of SCARLET and several previous anticoagulant studies,it is most important for new studies to grasp the following two points:(1)The enrolled cases should have sufficient disease severity and a clear standard for disseminated intravascular coagulation;(2)Heparin should not be used in combination with the investigated drugs.Multiple post-hoc analyses show that no combination of heparin will not increase the risk of thromboembolism.In fact,the combination of heparin can mask the true efficacy of the investigated drug.Due to the complexity of sepsis treatment and the limitations of clinical studies,the results of all treatment studies should be repeatedly verified,rather than be determined at one stroke.Some research conclusions contrary to disease physiology,pharmacology and clinical practice may be deceptive,and should be cautious rather than be simply accepted.On the other hand,the dissenting voices in the"consensus"scene are often well discussed by the authors and should be highly valued.
文摘A 19-year-old male patient who suffered from sudden and repeated multiple organ dysfunction syndrome one month after the bar removal procedure of Nuss surgery for pectus excavatum was admitted to our department.With organ function supportive treatment,the etiology was finally identified to be a bone spur located at the inner border of the left costa due to repeated friction between the implanted steel bar and the rib,which damaged the heart repeatedly and induced the consequent acute cardiac tamponade.After operation,the patient was successfully managed and discharged.Follow-ups till three years indicated a good recovery.
