To efficiently exploit the performance of single instruction multiple data （SIMD） architectures for video coding, a parallel memory architecture with power-of-two memory modules is proposed. It employs two novel ske...To efficiently exploit the performance of single instruction multiple data （SIMD） architectures for video coding, a parallel memory architecture with power-of-two memory modules is proposed. It employs two novel skewing schemes to provide conflict-free access to adjacent elements （8-bit and 16-bit data types） or with power-of-two intervals in both horizontal and vertical directions, which were not possible in previous parallel memory architectures. Area consumptions and delay estimations are given respectively with 4, 8 and 16 memory modules. Under a 0.18-pm CMOS technology, the synthesis results show that the proposed system can achieve 230 MHz clock frequency with 16 memory modules at the cost of 19k gates when read and write latencies are 3 and 2 clock cycles, respectively. We implement the proposed parallel memory architecture on a video signal processor （VSP）. The results show that VSP enhanced with the proposed architecture achieves 1.28× speedups for H.264 real-time decoding.展开更多
Idiopathic asthenozoospermia,a common factor in male infertility,is characterized by altered sperm motility function in fresh ejaculate.Although theβ-defensin 126(DEFB126)protein is associated with asthenozoospermia,...Idiopathic asthenozoospermia,a common factor in male infertility,is characterized by altered sperm motility function in fresh ejaculate.Although theβ-defensin 126(DEFB126)protein is associated with asthenozoospermia,DEFB126 gene polymorphisms have not been extensively studied.Therefore,the association between DEFB126 gene polymorphisms and asthenozoospermia requires further investigation.Screening was performed by semen analysis,karyotype analysis,and Y microdeletion detection,and 102 fertile men and 106 men with asthenozoospermia in Chengdu,China,were selected for DEFB126 gene sequence analyses.Seven nucleotide mutations and two nucleotide deletions in the DEFB126 gene were detected.rs11467417(317-318 del/del),rs11467497(163-166 wt/del),c.152T>C,and c.227A>G were significantly different between the control and asthenozoospermia groups,likely representing high-risk genetic factors for asthenozoospermia among males.DEFB126 expression was not observed in sperm with rs11467497 homozygous deletion and was unstable in sperm with rs11467417 homozygous deletion.The rs11467497 four-nucleotide deletion leads to truncation of DEFB126 at the carboxy-terminus,and the rs11467417 binucleotide deletion produces a non-stop messenger RNA(mRNA).The above deletions may be responsible for male hypofertility and infertility by reducing DEFB126 affinity to sperm surfaces.Based on in silico analysis,the amino acids 51M and 76K are located in the highly conserved domain;c.152T>C(M51T)and c.227A>G(K76R)are predicted to be damaging and capable of changing alternative splice,structural and posttranslational modification sites of the RNA,as well as the secondary structure,structural stability,and hydrophobicity of the protein,suggesting that these mutations are associated with asthenozoospermia.展开更多
基金Project (No. 2005AA1Z1271) supported by the Hi-Tech Research and Development Program (863) of China
文摘To efficiently exploit the performance of single instruction multiple data （SIMD） architectures for video coding, a parallel memory architecture with power-of-two memory modules is proposed. It employs two novel skewing schemes to provide conflict-free access to adjacent elements （8-bit and 16-bit data types） or with power-of-two intervals in both horizontal and vertical directions, which were not possible in previous parallel memory architectures. Area consumptions and delay estimations are given respectively with 4, 8 and 16 memory modules. Under a 0.18-pm CMOS technology, the synthesis results show that the proposed system can achieve 230 MHz clock frequency with 16 memory modules at the cost of 19k gates when read and write latencies are 3 and 2 clock cycles, respectively. We implement the proposed parallel memory architecture on a video signal processor （VSP）. The results show that VSP enhanced with the proposed architecture achieves 1.28× speedups for H.264 real-time decoding.
文摘Idiopathic asthenozoospermia,a common factor in male infertility,is characterized by altered sperm motility function in fresh ejaculate.Although theβ-defensin 126(DEFB126)protein is associated with asthenozoospermia,DEFB126 gene polymorphisms have not been extensively studied.Therefore,the association between DEFB126 gene polymorphisms and asthenozoospermia requires further investigation.Screening was performed by semen analysis,karyotype analysis,and Y microdeletion detection,and 102 fertile men and 106 men with asthenozoospermia in Chengdu,China,were selected for DEFB126 gene sequence analyses.Seven nucleotide mutations and two nucleotide deletions in the DEFB126 gene were detected.rs11467417(317-318 del/del),rs11467497(163-166 wt/del),c.152T>C,and c.227A>G were significantly different between the control and asthenozoospermia groups,likely representing high-risk genetic factors for asthenozoospermia among males.DEFB126 expression was not observed in sperm with rs11467497 homozygous deletion and was unstable in sperm with rs11467417 homozygous deletion.The rs11467497 four-nucleotide deletion leads to truncation of DEFB126 at the carboxy-terminus,and the rs11467417 binucleotide deletion produces a non-stop messenger RNA(mRNA).The above deletions may be responsible for male hypofertility and infertility by reducing DEFB126 affinity to sperm surfaces.Based on in silico analysis,the amino acids 51M and 76K are located in the highly conserved domain;c.152T>C(M51T)and c.227A>G(K76R)are predicted to be damaging and capable of changing alternative splice,structural and posttranslational modification sites of the RNA,as well as the secondary structure,structural stability,and hydrophobicity of the protein,suggesting that these mutations are associated with asthenozoospermia.
