Objective:To investigate the correlation of serum C-reactive protein (CRP) and procalcitonin (PCT) levels with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary diseas...Objective:To investigate the correlation of serum C-reactive protein (CRP) and procalcitonin (PCT) levels with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods:68 patients with acute exacerbation of COPD treated in our hospital between August 2012 and February 2016 were collected as observation group and 50 normal subjects receiving physical examination in our hospital during the same period were selected as normal control group. Radioimmunoassay was used to determine serum CRP and PCT levels;the observation group was further grouped according to the median of CRP and PCT levels, and serum levels of pro-inflammatory factors, anti-inflammatory factors and stress hormones of high level group and low level group were detected.Results:Serum CRP and PCT levels of observation group were significantly higher than those of normal control group (P<0.05);serum pro-inflammatory factors interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels of high CRP and PCT level groups within observation group were higher than those of low CRP and PCT level groups (P<0.05), anti-inflammatory factors interleukin-4 (IL-4) and interleukin-13 (IL-13) levels were lower than those of low CRP and PCT groups (P<0.05), and stress hormones angiotensin II (Ang II), aldosterone (ALD) and cortisol (Cor) levels were higher than those of low CRP and PCT level groups (P<0.05).Conclusions:Serum CRP and PCT levels in patients with acute exacerbation of COPD are positively correlated with the inflammatory response extent in the body, and can be used as the auxiliary means for early disease diagnosis, treatment effect evaluation and prognosis judgment.展开更多
文摘Objective:To investigate the correlation of serum C-reactive protein (CRP) and procalcitonin (PCT) levels with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods:68 patients with acute exacerbation of COPD treated in our hospital between August 2012 and February 2016 were collected as observation group and 50 normal subjects receiving physical examination in our hospital during the same period were selected as normal control group. Radioimmunoassay was used to determine serum CRP and PCT levels;the observation group was further grouped according to the median of CRP and PCT levels, and serum levels of pro-inflammatory factors, anti-inflammatory factors and stress hormones of high level group and low level group were detected.Results:Serum CRP and PCT levels of observation group were significantly higher than those of normal control group (P<0.05);serum pro-inflammatory factors interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels of high CRP and PCT level groups within observation group were higher than those of low CRP and PCT level groups (P<0.05), anti-inflammatory factors interleukin-4 (IL-4) and interleukin-13 (IL-13) levels were lower than those of low CRP and PCT groups (P<0.05), and stress hormones angiotensin II (Ang II), aldosterone (ALD) and cortisol (Cor) levels were higher than those of low CRP and PCT level groups (P<0.05).Conclusions:Serum CRP and PCT levels in patients with acute exacerbation of COPD are positively correlated with the inflammatory response extent in the body, and can be used as the auxiliary means for early disease diagnosis, treatment effect evaluation and prognosis judgment.
