BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has caused significant challenges for adolescent mental health.AIM To survey adolescent students in China to determine the effects of the COVID-19 pandemic on ...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has caused significant challenges for adolescent mental health.AIM To survey adolescent students in China to determine the effects of the COVID-19 pandemic on their mental health.METHODS A multicenter cross-sectional comparative investigation was conducted in March 2022.We collected demographic information and survey data related to the COVID-19 pandemic.The Patient Health Questionnaire-9 and Generalized Anxiety Disorder Screener scales were used for objective assessment of depression and anxiety.RESULTS We collected mental health questionnaires from 3184 students.The investigation demonstrated that adolescents most strongly agreed with the following items:Increased time spent with parents,interference with academic performance,and less travel.Conversely,adolescents most strongly disagreed with the following items:Not having to go to school,feeling an increase in homework,and not socializing with people;34.6%of adolescents were depressed before COVID-19,of which 1.9%were severely depressed.After COVID-19,26.3%of adolescents were prone to depression,of which 1.4%were severely depressed.24.4%of adolescents had anxiety before COVID-19,with severe anxiety accounting for 1.6%.After COVID-19,23.5%of adolescents were prone to anxiety,of which 1.7%had severe anxiety.CONCLUSION Chinese adolescents in different grades exhibited different psychological characteristics,and their levels of anxiety and depression were improved after the COVID-19 pandemic.Changes in educational management practices since the COVID-19 pandemic may be worth learning from and optimizing in long-term educational planning.展开更多
Objective:Matrix metalloproteinase 15(MMP15)has been previously reported to be involved in many cancers.However,its expression pattern in pancreatic ductal adenocarcinoma(PDAC)remains contradictory.In addition,its cli...Objective:Matrix metalloproteinase 15(MMP15)has been previously reported to be involved in many cancers.However,its expression pattern in pancreatic ductal adenocarcinoma(PDAC)remains contradictory.In addition,its clinicopathologic and prog-nostic significance in this malignancy has not been elucidated.Methods:Expression of MMP15 was immunohistochemically detected in a tissue microarray of formalin-fixed paraffin-em-bedded samples from 95 patients of PDAC after surgery.Its expression pattern and relations with clinicopathologic factors and disease-specific survival(DSS)were then evaluated.Finally,its expression and prognostic value were measured in the on-line publically available database,GEPIA,using TCGA data.Results:In comparison of all samples and 75 paired ones,MMP15 expression in tumor tissues was all significantly higher than that in para-tumor ones(P=.037 and.016).Furthermore,tumoral MMP15 expression was associated with peri-neural invasion.Survival anal-ysis showed that patients with high tumoral MMP15 expression had significantly poorer DSS than those with low MMP15 expression(P=.0059).In univariate and multivariate Cox regression tests,tumoral MMP15 expression was all significantly predictive for DSS.In the on-line publically available GEPIA database,MMP15 was also overexpressed in PDAC,but was not found to be prognostic.Conclusion:Our results indicated that MMP15 expression was elevated in operable PDAC and might have a prognostic impact.展开更多
Background: To determine the influence of right ventricular function in patients with constrictive pericarditis (CP) undergoing surgery and to compare the outcomes of patients who received surgery with those manage...Background: To determine the influence of right ventricular function in patients with constrictive pericarditis (CP) undergoing surgery and to compare the outcomes of patients who received surgery with those managed medically. Methods: Patients with the diagnosis of CP and healthy volunteers were recruited from January 2006 to November 2011. Patients with CP chose to either receive pericardiectomy or medical management. Echocardiographic measurements were performed to evaluate heart function, and survival was recorded. Results: A total of 58 patients with CP (36 received pericardiectomy, 22 managed medically), and 43 healthy volunteers were included. CP patients who received surgery had a higher survival rate than those managed medically (P = 0.003), and higher st, rvival was also seen in the subgroup of CP patients with severely impaired right systolic function. Albumin level, left ventricular end-diastolic dimension, and tricuspid regurgitation velocity were associated with survival in CP patients who received surgery. Conclusions: Preoperative right heart function does not affect surgical outcomes. Patients with severely impaired preoperative right systolic function obtain a greater survival advantage with surgery than with medical treatment.展开更多
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has caused significant challenges for adolescent mental health.AIM To survey adolescent students in China to determine the effects of the COVID-19 pandemic on their mental health.METHODS A multicenter cross-sectional comparative investigation was conducted in March 2022.We collected demographic information and survey data related to the COVID-19 pandemic.The Patient Health Questionnaire-9 and Generalized Anxiety Disorder Screener scales were used for objective assessment of depression and anxiety.RESULTS We collected mental health questionnaires from 3184 students.The investigation demonstrated that adolescents most strongly agreed with the following items:Increased time spent with parents,interference with academic performance,and less travel.Conversely,adolescents most strongly disagreed with the following items:Not having to go to school,feeling an increase in homework,and not socializing with people;34.6%of adolescents were depressed before COVID-19,of which 1.9%were severely depressed.After COVID-19,26.3%of adolescents were prone to depression,of which 1.4%were severely depressed.24.4%of adolescents had anxiety before COVID-19,with severe anxiety accounting for 1.6%.After COVID-19,23.5%of adolescents were prone to anxiety,of which 1.7%had severe anxiety.CONCLUSION Chinese adolescents in different grades exhibited different psychological characteristics,and their levels of anxiety and depression were improved after the COVID-19 pandemic.Changes in educational management practices since the COVID-19 pandemic may be worth learning from and optimizing in long-term educational planning.
基金kindly supported by the National Natural Science Foundation(81402027 and 81972324)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2016-I2M-3-019),China.
文摘Objective:Matrix metalloproteinase 15(MMP15)has been previously reported to be involved in many cancers.However,its expression pattern in pancreatic ductal adenocarcinoma(PDAC)remains contradictory.In addition,its clinicopathologic and prog-nostic significance in this malignancy has not been elucidated.Methods:Expression of MMP15 was immunohistochemically detected in a tissue microarray of formalin-fixed paraffin-em-bedded samples from 95 patients of PDAC after surgery.Its expression pattern and relations with clinicopathologic factors and disease-specific survival(DSS)were then evaluated.Finally,its expression and prognostic value were measured in the on-line publically available database,GEPIA,using TCGA data.Results:In comparison of all samples and 75 paired ones,MMP15 expression in tumor tissues was all significantly higher than that in para-tumor ones(P=.037 and.016).Furthermore,tumoral MMP15 expression was associated with peri-neural invasion.Survival anal-ysis showed that patients with high tumoral MMP15 expression had significantly poorer DSS than those with low MMP15 expression(P=.0059).In univariate and multivariate Cox regression tests,tumoral MMP15 expression was all significantly predictive for DSS.In the on-line publically available GEPIA database,MMP15 was also overexpressed in PDAC,but was not found to be prognostic.Conclusion:Our results indicated that MMP15 expression was elevated in operable PDAC and might have a prognostic impact.
文摘Background: To determine the influence of right ventricular function in patients with constrictive pericarditis (CP) undergoing surgery and to compare the outcomes of patients who received surgery with those managed medically. Methods: Patients with the diagnosis of CP and healthy volunteers were recruited from January 2006 to November 2011. Patients with CP chose to either receive pericardiectomy or medical management. Echocardiographic measurements were performed to evaluate heart function, and survival was recorded. Results: A total of 58 patients with CP (36 received pericardiectomy, 22 managed medically), and 43 healthy volunteers were included. CP patients who received surgery had a higher survival rate than those managed medically (P = 0.003), and higher st, rvival was also seen in the subgroup of CP patients with severely impaired right systolic function. Albumin level, left ventricular end-diastolic dimension, and tricuspid regurgitation velocity were associated with survival in CP patients who received surgery. Conclusions: Preoperative right heart function does not affect surgical outcomes. Patients with severely impaired preoperative right systolic function obtain a greater survival advantage with surgery than with medical treatment.