期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
铅暴露时间对大脑皮质ATG5、Beclin1、LC3B表达的影响 被引量:3
1
作者 卢北玲 史剑飞 周军 《中国现代医学杂志》 CAS 2018年第35期18-22,共5页
目的通过复制成年动物铅暴露模型,研究铅暴露时间长短对大脑皮质自噬蛋白ATG5、Beclin1、LC3B表达的变化。方法选取18只豚鼠随机分为4组:对照组(3只),以及铅暴露15、60和90 d组(每组5只)。用0.2%醋酸铅饮用水复制动物铅暴露模型,对照组... 目的通过复制成年动物铅暴露模型,研究铅暴露时间长短对大脑皮质自噬蛋白ATG5、Beclin1、LC3B表达的变化。方法选取18只豚鼠随机分为4组:对照组(3只),以及铅暴露15、60和90 d组(每组5只)。用0.2%醋酸铅饮用水复制动物铅暴露模型,对照组给予等量的生理盐水喂养;免疫组织化学法检测ATG5、Beclin1和LC3B的表达。结果与对照组相比,不同时间铅暴露组自噬蛋白ATG5、Beclin1和LC3B的阳性表达升高(P<0.05)。铅暴露90 d组的ATG5表达水平与各暴露组比较,差异有统计学意义(P<0.05)。铅暴露15 d组与60 d组的ATG5表达水平比较,差异无统计学意义(P>0.05)。各暴露组Beclin1和LC3B蛋白水平比较,差异无统计学意义(P>0.05)。结论环境铅饮用水可通过自噬蛋白ATG5、Beclin1及LC3B引起大脑皮质区的自噬反应,推测铅暴露激活的早期自噬反应可能对大脑皮质发挥神经毒性作用,对成年豚鼠大脑造成不可逆转的损害。 展开更多
关键词 铅中毒 蛋白 大脑皮质 自噬
下载PDF
Acupoint selection rules in treatment of chemotherapy-induced nausea and vomiting with acupuncture and moxibustion 被引量:4
2
作者 Xiao LI Chen ZHAO jian-fei shi 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第2期149-156,共8页
Objective:To analyze the acupoint selection rules in acupuncture treatment for chemotherapy-induced nausea and vomiting(CINV)in China through data mining technology.Methods:The relevant literature on acupuncture treat... Objective:To analyze the acupoint selection rules in acupuncture treatment for chemotherapy-induced nausea and vomiting(CINV)in China through data mining technology.Methods:The relevant literature on acupuncture treatment for CINV were searched from SinoMed,China National Knowledge Infrastructure(CNKI),Wanfang,VIP and Pubmed databases from the establishment to January 3,2021 and the worksheet was set up for the information extraction of acupuncture-moxibustion prescriptions.Using IBM SPSS Statistics 25.0 and SPSS Modeler 18.0 software,cluster analysis and association rule analysis were conducted to explore the rules of acupoint selection.Results:A total of 179 articles were eligible,including 206 acupuncture prescriptions and 64 acupoints.The total use frequency of acupoints was 784 times.The acupoints with the highest use frequency were Zúsānlǐ(足三里ST36),Zhōngwǎn(中脘CV12)and Nèiguān(内关PC6).The commonly used meridians included stomach meridian of foot-yangming,conception vessel,pericardium meridian of hand-jueyin and bladder meridian of foot-taiyang.The acupoints located on the chest,the abdomen and the lower limbs were mostly selected.Five-shu points and crossing points were highly involved in terms of the specific points.The most common combination was ST36,CV12 and PC6.Conclusion:In treatment of acupuncture for CINV,the acupoints were generally selected from stomach meridian of foot-yangming,conception vessel,pericardium meridian of hand-jueyin.Front-mu points on the chest and the abdomen,the he-sea points and lower he-sea points in the lower limbs are commonly used.The core acupoint prescription of acupuncture for CINV included ST36,CV12 and PC6. 展开更多
关键词 Chemotherapy-induced nausea and vomiting(CINV) ACUPUNCTURE Data mining Acupoint selection rules
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部