Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this study.They were randomly assigned to receive either aflibercept or a combination of aflibercept and TA.Injections once a month for a total of three injections.Central macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly treatment.RESULTS:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both groups.CONCLUSION:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and SRF.However,both aflibercept and combination therapy show no significant change in the area of FAZ.

Multi-slice spiral computed tomography in diagnosing unstable pelvic fractures in elderly and effect of less invasive stabilization

BACKGROUND Older people are more likely to experience pelvic fractures than younger people.Multi-slice spiral computed tomography(CT)uses three-dimensional(3D)reconstruction technology to generate 3D images that can clearly demonstrate the 3D space of fractures and detect fractures at a higher rate.AIM To investigate the clinical value of multi-slice spiral CT 3D reconstruction in the diagnosis of unstable pelvic fractures in the elderly as well as the effect of less invasive stabilization.METHODS A total of 86 patients with unstable pelvic fractures treated between March 2016 and March 2019 underwent femoral supracondylar bone traction before surgery.Pelvic radiography and multi-row spiral CT were performed successively once the patient’s vital signs and hemodynamic indices were stable.Secondary processing of the original data was performed to obtain 3D reconstruction images and determine the vertical displacement of the pelvis.After basic or complete reduction,minimally invasive internal fixation using hollow lag screws was performed.The detection rates of fracture location and classification by X-ray and CT reconstruction were compared.Patients were divided into two groups according to the presence or absence of preoperative 3D reconstruction to compare postoperative reduction,wound healing time,fracture healing time,hospitalization time,visual analog scale(VAS)score,poor internal fixation,and functional recovery.RESULTS The diagnostic coincidence rates of X-rays for pubic symphysis,ilium wing,sacroiliac periarticular,and sacral fractures were lower than those of CT reconstruction.The coincidence rate of CT reconstruction in the clinical classification of pelvic fractures was 100%,whereas 11 cases were misdiagnosed by X-ray;the total coincidence rate was 87.21%.The total excellent and good rates of postoperative reduction were significantly higher in the study group than in the control group(P<0.05).The wound healing,fracture healing,and hospitalization times were significantly shorter in the study group than in the control group(P<0.05).The VAS scores decreased in both groups postoperatively and were lower in the study group than in the control group(P<0.05).The total incidence of poor postoperative internal fixation was significantly lower in the study group than in the control group(P<0.05).The overall rate of postoperative functional recovery was significantly higher in the study group than in the control group(P<0.05).CONCLUSION Multi-slice spiral CT has high guiding significance for the diagnosis,classification,and treatment of unstable pelvic fractures in the elderly.Preoperative 3D reconstruction can effectively shorten the operation time and promote fracture healing,while minimally invasive internal fixation can effectively reduce pain and promote functional recovery of fracture sites,making it worthy of clinical application.

Skarn mineralogy and its geological significance for the Tayuan (Cu-Mo)-Pb-Zn deposit, northern Daxinganling metallogenic belt

The Tayuan(Cu-Mo)-Pb-Zn deposit is located in the northern part of Daxinganling,NE China.Lenticular ore body occurs in the skarn zone.The skarn minerals mainly include garnet,pyroxene,epidote and wollastonite.Electron microprobe analysis shows that the end member of garnet is mainly andradite(Ad_(62-97)Gr_(11-45),the pyroxene is mainly diopside,and epidote is mainly clinozoisite.These characteristics indicate that the Tayuan polymetallic skarn deposit is mainly calcareous skarn.Sometimes the content zonation can be observed in garnets.With one garnet crystal,content is shifty from the core to the rim.In general,the iron content in the core is higher than in the edge.The content in the garnet shows that the garnet in the Tayuan deposit formed from weak oxidation in alkaline environment with the oxygen fugacity increasing,suggesting that the hydrothermal fluid evolved from an acidic to a slight alkaline state.In the Tayuan polymetallic deposit,the ratio of Mn/Fe in pyroxene is about 1.3,and of Mg/Fe,it is about 2.The components of garnet in the Tayuan deposit plot in the field of the typical skarn Zn,Cu,Mo deposits in the world.

Underwater acoustic communication and the general performance evaluation criteria

Driven by the huge demand to explore oceans, underwater wireless communications have been rapidly developed in the past few decades. Due to the complex physical characteristics of water, acoustic wave is the only media available for underwater wireless communication at any distance. As a result, underwater acoustic communication(UAC) is the major research field in underwater wireless communication. In this paper, characteristics of underwater acoustic channels are first introduced and compared with terrestrial communication to demonstrate the difficulties in UAC research. To give a general impression of the UAC, current important research areas are mentioned. Furthermore, different principal modulation-based schemes for short-and medium-range communications with high data rates are investigated and summarized. To evaluate the performance of UAC systems in general,three criteria are presented based on the research publications and our years of experience in high-rate short-to medium-range communications. These three criteria provide useful tools to generally guide the design and evaluate the performance of underwater acoustic communication systems.

REMARKS ON ERROR ESTIMATES FOR THE TRUNC PLATE ELEMENT

This paper provides a simplified derivation for error estimates of the TRUNC plate element. The error analysis for the problem with mixed boundary conditions is also discussed.