A mixed blessing for liver transplantation patients—Rapamycin

Background:Liver transplantation(LT)is an effective treatment option for end-stage liver disease.Mammalian target of rapamycin(m TOR)inhibitors,such as rapamycin,are widely used post LT.Data sources:In this review,we focused on the anti-cancer activities and metabolic side effects of rapamycin after LT.The literature available on Pub Med for the period of January 1999-September 2022 was reviewed.The key words were rapamycin,sirolimus,liver transplantation,hepatocellular carcinoma,diabetes,and lipid metabolism disorder.Results:Rapamycin has shown excellent effects and is safer than other immunosuppressive regimens.It has exhibited excellent anti-cancer activity and has the potential in preventing hepatocellular carcinoma(HCC)recurrence post LT.Rapamycin is closely related to two long-term complications after LT,diabetes and lipid metabolism disorders.Conclusions:Rapamycin prevents HCC recurrence post LT in some patients,but it also induces metabolic disorders.Reasonable use of rapamycin benefits the liver recipients.

Distal clavicle fractures treated by anteroinferior plating with a single screw: Two case reports

BACKGROUND For the treatment of distal clavicle fractures,each treatment method has its own advantages and disadvantages,and there is no optimal surgical solution.CASE SUMMARY Based on this,we report 2 cases of distal clavicle fractures treated utilizing an anterior inferior plate with a single screw placed in the distal,in anticipation of providing a better surgical approach to distal clavicle fracture treatment.Two patients were admitted to the hospital after trauma with a diagnosis of distal clavicle fracture,and were admitted to the hospital for internal fixation of clavicle fracture by incision and reduction,with good postoperative functional recovery.CONCLUSION With solid postoperative fixation and satisfactory prognostic functional recovery,this technique has been shown to be simple,easy to perform and effective.

Correcting the Contamination of Second-order Spectra:Improving HαMeasurements in Reverberation Mapping Campaigns

Long-term spectroscopic monitoring campaigns on active galactic nuclei(AGNs)provide a wealth of information about its interior structure and kinematics.However,a number of the observations suffer from the contamination of second-order spectra(SOS)which will introduce some undesirable uncertainties at the red side of the spectra.In this paper,we test the effect of SOS and propose a method to correct it in the time domain spectroscopic data using the simultaneously observed comparison stars.Based on the reverberation mapping(RM)data of NGC 5548 in2019,one of the most intensively monitored AGNs by the Lijiang 2.4 m telescope,we find that the scientific object,comparison star,and spectrophotometric standard star can jointly introduce up to~30%SOS for Grism 14.This irregular but smooth SOS significantly affects the flux density and profile of the emission line,while having little effect on the light curve.After applying our method to each spectrum,we find that the SOS can be corrected effectively.The deviation between corrected and intrinsic spectra is~2%,and the impact of SOS on time lag is very minor.This method makes it possible to obtain the HαRM measurements from archival data provided that the spectral shape of the AGN under investigation does not have a large change.

Quality Control of YFOSC Data I. The On-site Quick Analysis System

The Lijiang 2.4 m Telescope(LJT)is one of the most important telescopes for general astronomical observations in China.Yunnan Faint Object Spectrograph and Camera(YFOSC)is a widely used instrument mounted on the LJT,which occupies for~80%of the observing time of the LJT,and thus instrument health and data quality of the YFOSC are very important for both the telescope maintenance team and users of the LJT.So we develop an automated data analysis system for the quality control(QC)of YFOSC data.This system is also a new function of the observing support of the YFOSC.Based on the system,YFOSC data can be reduced quickly as they are acquired and QC parameters are extracted.Observers can assess the quality of their data and make a possible revision of their observing plan in time.These parameters can also be used to check the health of the YFOSC,which is helpful for the telescope maintenance team to find potential problems.All of these aim at improving the productivity of the LJT.

番茄外泌体的分离提取工艺优化及其作为药物载体的可行性分析

目的优化番茄外泌体提取工艺,初步探索番茄外泌体作为纳米载体的可行性。方法利用蔗糖密度梯度法提取番茄外泌体;动态光散射仪和透射电镜鉴定外泌体纳米粒子特征;用MTT法检测外泌体对A549、A2780及HONE1(EBV+)3种肿瘤细胞的毒性。构建外泌体携带模型药物DiI和目的基因反义EBV-miR-BART7-3p的纳米药物,考察其细胞摄取能力,实时荧光定量聚合酶链反应检测基因药物的沉默效果。结果优化工艺可获得具有纳米粒径的高收率外泌体(1.31 g/kg),呈球形脂质双分子层结构,并对细胞无毒性。外泌体构建的纳米药物可被细胞摄取并分布于胞浆。外泌体负载基因可有效降低目的基因的表达水平(P<0.05)。结论多步差速离心法和蔗糖密度梯度法可优化番茄外泌体的提取工艺,番茄外泌体可作为优良药物载体。

Oxygen vacancy enhancing mechanism of nitrogen reduction reaction property in Ru/TiO2

To search the new effective nitrogen reduction reaction(NRR)electrocatalyst is very important for the ammonia-based industry.Herein,we reported the design of a novel NRR electrocatalyst with Ru NPs loaded on oxygen-vacancy TiO2(Ru/TiO2-Vo).Structural characterizations revealed that oxygen vacancy was loaded in the matrix of Ru/TiO2-Vo.Electrocatalytic results indicated that Ru/TiO2-Vo showed good NRR performance(2.11μg h^-1 cm^-2).Contrast tests showed that NRR property of Ru/TiO2-Vo was much better than those of Ru/TiO-12(B)(0.53μg hcm^-2)and Ru/P25(0.42μg h^-1 cm^-2).Furthermore,density functional theory calculation results indicated catalytic mechanism of NRR and rate-determining step(*N2+1/2 H2→*N+*NH)was the potential-determining step with the overpotential requirement of 0.21 V.A combination of electronic structure analysis and catalytic measurement shed light on the synergistic effect of Ru and oxygen vacancy on the NRR performance.

Lijiang 2.4-meter Telescope and its instruments

The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational conditions.During its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized.

Mineral composition and organic geochemistry of the Lower Cretaceous Xiagou Formation source rock from the Qingxi Sag,Jiuquan Basin, Northwest China

The Lower Cretaceous Xiagou Formation contains the major source rocks for the crude oils discovered in the Qingxi Sag and the South Uplift in the Jiuquan Basin, northwestern China. The Xiagou Formation source rock was formed in a closed,anoxic, reducing, alkaline lacustrine environment with a high salinity. Its high content of brittle minerals is favorable for the fracturing of reservoirs in source rock formations in the Qingxi Sag. The Xiagou Formation contains a great number of fair to excellent source rocks, and their organic matter（OM） came chiefly from plankton/algae and high plants as well as possibly bacterial organisms. The Xiagou Formation source rocks mainly contain Type II OM and some Type III and Type I OM, with good oil-generating potential. The source rock maturity is mainly in the early-mature and mature stages, and its Rovalue corresponding to oil peak is about 0.8%, which is lower than classic oil peak Rovalue of 1.0%; therefore, a great deal of hydrocarbon was generated before the classic oil peak Ro= 1.0%. Mature source rock in the Xiagou Formation tends to be distributed in the older members and at a greater depth. There is a better exploration potential of tight oil in the deep Qingxi Sag.

Astronomical Site Monitoring System at Lijiang Observatory

We installed two sets of Astronomical Site Monitoring Systems(ASMSs)at Lijiang Observatory(GMG),for the running of the 2.4-meter Lijiang optical telescope(LJT)and the 1.6-meter Multi-channel Photometric Survey Telescope(Mephisto).The Mephisto is under construction.The ASMS has been running on robotic mode since 2017.The core instruments:Cloud Sensor,All-Sky Camera and AutonomousDIMM that are developed by our group,together with the commercial Meteorological Station and Sky Quality Meter,are combined into the astronomical optical site monitoring system.The new Cloud Sensor's Cloud-Clear Relationship is presented for the first time,which is used to calculate the All-Sky cloud cover.We designed the Autonomous-DIMM located on a tower,with the same height as LJT.The seeing data have been observed for a full year.ASMS's data for the year 2019 are also analysed in detail,which are valuable to observers.

Defect CTF derived Ru-based catalysts for high performance overall water splitting reaction

Research on water-splitting electrocatalysts is crucial to establishing a solution to the energy crisis.Herein,we report a facile bottom-up strategy for the preparation of high performance supported electrocatalysts for overall water-splitting reaction via a rationally designed defect covalent triazine frameworks(CTFs)support.Specifically,defect CTFs are obtained via binary-precursor polymerization,followed by loading Ru nanoparticles(Ru/D-CTFs-900)with high HER performance at a current density of 10 mA cm-2.The overpotential is only 17 mV.Calcination of the resultant Ru–RuO2/D-CTFs-300 in air,produces excellent OER performance with 190 mV overpotential(at 10 mA cm-2).Furthermore,overall water splitting measurements reveal the potential of 1.47 V,which is better than the majority of the reported Ru-based catalysts.Moreover,density functional theory calculation results show that excellent electrocatalytic properties are attributed to the synergistic effect of Ru nanoparticles and carbon support.

Molecule opacities of X^2Σ^+, A^2Π, and B^2Σ^+ states of CS^+

Carbon sulfide cation(CS^+) plays a dominant role in some astrophysical atmosphere environments. In this work, the rovibrational transition lines are computed for the lowest three electronic states, in which the internally contracted multireference configuration interaction approach(MRCI) with Davison size-extensivity correction(+Q) is employed to calculate the potential curves and dipole moments, and then the vibrational energies and spectroscopic constants are extracted. The Frank–Condon factors are calculated for the bands of X^2^+Σ^+–A^2Π and X^2Σ^+–B^2Σ^+systems, and the band of X^2Σ^+–A^2Π is in good agreement with the available experimental results. Transition dipole moments and the radiative lifetimes of the low-lying three states are evaluated. The opacities of the CS^+ molecule are computed at different temperatures under the pressure of 100 atms. It is found that as temperature increases, the band systems associated with different transitions for the three states become dim because of the increased population on the vibrational states and excited electronic states at high temperature.

Optical identification of radio-loud active galactic nuclei in the ROSAT-Green-Bank sample with SDSS spectroscopy

Results of extended and refined optical identification of 181 radio/X-ray sources in the RASS-Green Bank （RGB） catalog are presented （Brinkmann et al. 1997） which have been spectroscopically observed in the Sloan Digital Sky Survey （SDSS） DR5. The SDSS spectra of the optical counterparts are modeled in a careful and selfconsistent way by incorporating the host galaxy＇s starlight. Optical emission line parameters are presented, which are derived accurately and reliably, along with the radio 1.4- 5 GHz spectral indices estimated using （non-simultaneous） archival data. For 72 sources, the identifications are presented for the first time. It is confirmed that the majority of strong radio/X-ray emitters are radio-loud active galactic nuclei （AGNs）, particularly blazars. Taking advantage of the high spectral quality and resolution and our refined spectral modeling, we are able to disentangle narrow line radio galaxies （NLRGs）, as vaguely termed in most previous identification work, into Seyfert II galaxies and LINERs （low-ionization nuclear emission regions）, based on the standard emission line diagnostics. The NLRGs in the RGB sample, mostly belonging to ＇weak line radio galaxies＇, are found to have optical spectra consistent predominantly with LINERs, and only a small fraction with Seyfert II galaxies. A small number of LINERs have radio power as high as 10623 - 10^26 W Hz^- 1 at 5 GHz, being among the strongest radio emitting LINERs known so far. Two sources are identified with radio-loud narrow line Seyfert 1 galaxies （NLS 1 s）, a class of rare objects. The presence is also confirmed of flat-spectrum radio quasars whose radio-optical-X-ray effective spectral indices are similar to those of High-energy peaked BL Lacs （HBLs）, as suggested by Padovani et al., although it is still a debate as to whether this is the case for their actual spectral energy distributions.

Molecular opacities of low-lying states of oxygen molecule

The X^3Σg^-,A^'3△u,A^3Σ^u+,1^3Πg,and B^3Σu^-electronic states of oxygen molecule(O2)are calculated by the multiconfiguration self-consisted filed(MRCI)+Q method with the scalar relativistic correction and core-valence correlation correction.The obtained spectroscopic constants of the low-lying bound states are in excellent agreement with measurements.Based on the accurately calculated structure parameters,the opacities of the oxygen molecule at the temperatures of 1000 K,2000 K,2500 K,and 5000 K under a pressure of 100 atm(1 atm=1.01325×10^5 Pa)and the partition functions between 10 K and 10^4 K are obtained.It is found that with the increase of temperature,the opacities for transitions in a long wavelength range are enlarged because of the larger population on excited electronic states at the higher temperatures.

Is BZB J1450+5201 the most distant gamma-ray BL Lacertae object?

BL Lacertae （BL Lac） objects at high redshifts （z ≥ 2） are rarely detected. Through careful analysis of its Sloan Digital Sky Survey spectrum, BZB J1450＋5201 is confirmed to be a high-z BL Lac object with z ≥ 2.471 by identifying the Lyα 1216 and CIV 1548/1550 absorption lines. This indicates that BZB J1450＋5201 is the most distant BL Lac object discovered to date. Careful analysis of the five-year Fermi-LAT data of 2FGL J1451.0＋5159 shows that its γ-ray emission is robust with a confidence level of 6.2σ at 1-3 GeV and 6.7σ at 3-10 GeV. This analysis with the five-year data overcomes confusion with its bright neighbor, which is a problem when analyzing the two-year data. In addition, 2FGL J 1451.0＋5159 is confirmed to be associated with BZB J1450＋5201 using the five-year data. The analysis of multiwavelength data, from radio to γ-ray energies, indicates that BZB J1450＋5201 is an intermediate synchrotron peaked （ISP） source. Its multiwavelength properties are consistent with distributions of other ISP sources at lower redshifts in the second Fermi-LAT AGN catalog. The pure synchrotron self-Compton （SSC） model seems to be disfavored, but the scattering of weak external emission plus the SSC process can provide a satisfactory description of the broadband emission.

Investigations of the dielectronic recombination of phosphorus-like tin at CSRm

The electron–ion recombination for phosphorus-like^（112） Sn^（35＋）has been measured at the main cooler storage ring of the Heavy Ion Research Facility in Lanzhou, China, employing an electron–ion merged-beams technique. The absolute total recombination rate coefficients for electron–ion collision energies from 0 e V–14 e V are presented. Theoretical calculations of recombination rate coefficients were performed using the Flexible Atomic Code to compare with the experimental results. The contributions of dielectronic recombination and trielectronic recombination on the experimental rate coefficients have been identified with the help of the theoretical calculation. The present results show that the trielectronic recombination has a substantial contribution to the measured electron–ion recombination spectrum of^（112）Sn^（35＋）. Although a reasonable agreement is found between the experimental and theoretical results the precise calculation of the electron–ion recombination rate coefficients for M-shell ions is still challengeable for the current theory.

Debye-screening effect on electron-impact excitation of helium-like Al^(11+)and Fe^(24+)ions

Debye-screening effects on the electron-impact excitation(EIE)processes for the dipole-allowed transition 1 s_(2)^(1)S→1 s2 p^(1)P in He-like Al^(11+)and Fe^(24+)ions are investigated using the fully relativistic distorted-wave methods with the Debye-Huckel(DH)model potential.Debye-screening effects on the continuum-bound(CB)interaction and target ion are discussed,both of which result in reduction of EIE cross sections.This reduction due to screening on the CB interaction is dominant.The non-spherical and spherical DH potentials are adopted for considering the screening effect on the CB interaction.It is found that the spherical DH potential could significantly overestimate the influence of plasma screening on EIE cross sections for multielectron He-like ions.

The photometric monitoring of γ-ray-loud narrow-line Seyfert 1 galaxy 1H0323+342 from 2006 to 2010

1H 0323＋342 is a γ-ray-loud narrow-line Seyfert 1 galaxy（NLS1）. The variability mechanism of γ-ray-loud NLS1 s remains unclear. We have observed 1H 0323＋342 photometrically from 2006 to2010 with a total of 41 nights of observations in order to constrain the variability mechanism. Intraday variabilities（IDVs） are detected on four nights. When considering the nights with time spans 〉 2 hours,the duty cycle is 28.3%. The average variability amplitude is 10.8% for IDVs and possibly variable nights. In the color-magnitude diagram, there are bluer-when-brighter chromatic trends for intraday and long-term timescales, which could be explained by the shock-in-jet model, and also could possibly be due to two distinct components or an accretion disk model.

YFPOL: A Linear Polarimeter of Lijiang 2.4 m Telescope

Polarimetry plays an important role in investigating physical properties for celestial objects. We present a polarimeter named YFPOL for the Cassegrain focus of the Lijiang 2.4 m Telescope(LJT) of Yunnan Observatories, Chinese Academy of Sciences. YFPOL is a traditional single-beam polarimeter with a rotating polarizer. As the focal-reducer instrument Yunnan Faint Object Spectrograph and Camera(YFOSC) is always positioned on the Cassegrain focal plane of LJT, we develop two sets of ultra-thin(thickness <12 mm) polarizer rotation control systems with wireless charging and control functions, which are suitable for mounting on the two front-wheels of YFOSC. One set is used as the polarimetric calibration unit, and the other is for the polarimetric modulation unit. Both of the polarizers have an ultra-high contrast ratio of 1,000,000:1 in the optical band. We investigate the instrumental polarization characteristics(IPCs) in the full field of view that is transferred from YFOSC. Furthermore, we identify that the IPCs change when the Cassegrain axis rotates. The spurious polarization from the IPCs can be effectively minimized by flat-fielding using the unpolarized domeflat, when the Cassegrain rotation angle is the same or nearest to that of the polarization observation. We develop a quasiautomatic pipeline for YFPOL and its effectiveness has been verified by tests of the polarimetric observation with blazar S5 0716+714. The calibration is performed by observing the zero-polarized and highly-polarized standard stars. We successfully reach high precision polarization in the 7’ field of view, and the systematic uncertainty is below 0.8% for a V = 11.68 target with a 10 s exposure. The instrument polarization angle offset is 2°. 6. YFPOL is not only a simple polarimeter, but also a spectropolarimeter with grisms that can be considered in the future.

Relativistic R-matrix calculations for L-shell photoionization cross sections of CⅡ

The photoionization cross section of the ground state 2s22p 2Po1/2 and the first excited state 2s22p2po1/2 of C II ions are systematically calculated using the fully relativistic R-matrix code DARC. The detailed resonances are presented and identified for the photon energy ranging from threshold （24.38 eV） up to 41.5 eV where the L-shell （2p, 2s） photoionization process is dominant. In the calculations, the relativistic effect and electronic correlation effect are well considered. It is found that the relativistic effect is very important for the light atomic system CII, which accounts for experimentally observed fine structure resonance peaks. A careful comparison is made between the present results and the experimental values, and also other theoretical data available in the literature, showing that good agreement is obtained for the resonance peaks.

M1 transition energy and rate in the ground configuration of Ag-like ions with 62 ≤ Z ≤ 94

Systematic calculations and assessments are performed for the magnetic dipole(M1)transition energies and rates between the ^(2)F^(o)_(5/2,7/2) levels in the ground configuration 4d104f along the Ag-like isoelectronic sequence with 62≤Z≤94 based on the second-order many-body perturbation theory implemented in the Flexible Atomic Code.The electron correlations,Breit interaction and quantum electrodynamics effects are taken into account in the present calculations.The accuracy and reliability of our results are evaluated through comprehensive comparisons with available measurements and other theoretical results.For transition energies,our results are in good agreement with the recent experimental data obtained from the electron beam ion traps within 0.18%.The maximum discrepancy between our results and those obtained with the large-scale multiconfiguration Dirac–Hartee–Fock calculations by Grumer et al.[Phys.Rev.A 89062501(2014)]is less than 0.13%along the isoelectronic sequence.Furthermore,the corresponding M1 transition rates are also reported.The present results can be used as the benchmark and useful for spectra simulation and diagnostics of astrophysical and fusion plasmas.