Both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced....Both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced. After sciatic nerve injury, tacrolimus, an immunosuppressant, was（or was not） intraperitoneally administered. At 4, 8 and 12 weeks after surgery, Masson＇s trichrome, hematoxylin-eosin, and toluidine blue staining results revealed that brain injury or tacrolimus alone or their combination alleviated gastrocnemius muscle atrophy and sciatic nerve fiber impairment on the experimental side, simultaneously improved sciatic nerve function, and increased gastrocnemius muscle wet weight on the experimental side. At 8 and 12 weeks after surgery, brain injury induction and/or tacrolimus treatment increased action potential amplitude in the sciatic nerve trunk. Horseradish peroxidase retrograde tracing revealed that the number of horseradish peroxidase-positive neurons in the anterior horn of the spinal cord was greatly increased. Brain injury in combination with tacrolimus exhibited better effects on repair of injured peripheral nerves than brain injury or tacrolimus alone. This result suggests that brain injury in combination with tacrolimus promotes repair of peripheral nerve injury.展开更多
MIL-140-type metal organic frameworks （isoreticular zirconium oxide MOFs） with different aromatic moieties （phenyl, naphthalene, and biphenyl） have been synthesized and employed as the supports of palladium nanopa...MIL-140-type metal organic frameworks （isoreticular zirconium oxide MOFs） with different aromatic moieties （phenyl, naphthalene, and biphenyl） have been synthesized and employed as the supports of palladium nanoparticles （Pd NiPs）. The catalysts were characterized by XRD, BET, TEM and CO chemisorption. The results reveal that Pd NPs are homogeneously dispersed on all materials whereas different accessibility to CO is observed. The hydrogenation performance in C=C saturation with respect to the effect of the aromatic moiety is compared. The Pd/MIL-140A MOF with the highest hydrogenation activity among the three catalysts comprised of different aromatic rings points to a unique Pd-π interaction between Pd and frameworks consisting of mono-phenyl groups （C6H4）.展开更多
基金supported by a grant from the Mandatory Project of Health Department of Hebei Province of China,No.20130027a grant from the Mandatory Project of Science and Technology Department of Hebei Province of China,No.142777105Da grant from Science and Technology Bureau of Chengde City of Hebei Province of China,No.20123128
文摘Both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced. After sciatic nerve injury, tacrolimus, an immunosuppressant, was（or was not） intraperitoneally administered. At 4, 8 and 12 weeks after surgery, Masson＇s trichrome, hematoxylin-eosin, and toluidine blue staining results revealed that brain injury or tacrolimus alone or their combination alleviated gastrocnemius muscle atrophy and sciatic nerve fiber impairment on the experimental side, simultaneously improved sciatic nerve function, and increased gastrocnemius muscle wet weight on the experimental side. At 8 and 12 weeks after surgery, brain injury induction and/or tacrolimus treatment increased action potential amplitude in the sciatic nerve trunk. Horseradish peroxidase retrograde tracing revealed that the number of horseradish peroxidase-positive neurons in the anterior horn of the spinal cord was greatly increased. Brain injury in combination with tacrolimus exhibited better effects on repair of injured peripheral nerves than brain injury or tacrolimus alone. This result suggests that brain injury in combination with tacrolimus promotes repair of peripheral nerve injury.
基金supported by the Science and Technology Commission of Shanghai Municipality(No.13ZR1417900)the National Natural Science Foundation of China(No.21203065)
文摘MIL-140-type metal organic frameworks （isoreticular zirconium oxide MOFs） with different aromatic moieties （phenyl, naphthalene, and biphenyl） have been synthesized and employed as the supports of palladium nanoparticles （Pd NiPs）. The catalysts were characterized by XRD, BET, TEM and CO chemisorption. The results reveal that Pd NPs are homogeneously dispersed on all materials whereas different accessibility to CO is observed. The hydrogenation performance in C=C saturation with respect to the effect of the aromatic moiety is compared. The Pd/MIL-140A MOF with the highest hydrogenation activity among the three catalysts comprised of different aromatic rings points to a unique Pd-π interaction between Pd and frameworks consisting of mono-phenyl groups （C6H4）.
