Background:It remains unclear what the antiviral therapy affects disease-free survival(DFS) and overall survival(OS)of patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC) at different tumor stag...Background:It remains unclear what the antiviral therapy affects disease-free survival(DFS) and overall survival(OS)of patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC) at different tumor stages and baseline HBV DNA levels.In this study,we analyzed the association of antiviral treatment with DFS and OS based on the stratification of baseline HBV DNA load in early-stage(stages Ⅰ and Ⅱ) HCC patients.Methods:We included 445 patients with early-stage HBV-related HCC who underwent curative resection,and then classified them into four subgroups based on baseline HBV DNA load and antiviral therapy stratification.The KaplanMeier and Cox regression analyses were performed to determine the association of clinical characteristics with survival.Results:The median follow-up period was 74 months.For all patients,cumulative OS rates in the antiviral group were significantly higher than those in the non-antiviral group(log-rank test,P = 0.023),whereas no significant differences in DFS rates were observed.High baseline HBV DNA level was a risk factor associated with short DFS and OS in all patients.In patients with baseline HBV DNA levels ≥2000 lU/mL,antiviral treatment was significantly associated with prolonged DFS and OS(log-rank test,P = 0.041 and 0.001,respectively).In patients with HBV DNA levels <2000 lU/mL or undetectable,antiviral treatment did not show a significant benefit in prolonging DFS and OS.Conclusions:High baseline HBV DNA levels are associated with poor prognosis in the patients with early-stage HCC,and the antiviral treatment could generate survival benefits for the patients.Therefore,antiviral treatment should be given for these patients.However,the effect of antiviral treatment on the patients with low viral load remains unclear,and further investigation is warranted.展开更多
1.Objectives The porphyry copper deposits (PCD) are usually hosted in a multistage intrusive complex but only causallyrelated tospecific magma of high oxidation state and water content. The copper enrichment of the po...1.Objectives The porphyry copper deposits (PCD) are usually hosted in a multistage intrusive complex but only causallyrelated tospecific magma of high oxidation state and water content. The copper enrichment of the porphyry system is caused by accumulation during magmatic differentiation (Hou ZQ et al., 2015). Thus, study on magmatic evolution and Cu mineralization process is important for understanding the formation of PCD.展开更多
基金supported by project grants from the National Natural Science Foundation of China(no.81201603 for Dr.XML)the Guangdong Natural Science Funds(No.S2012010009631 for Dr.XML)the International Program for Ph.D.Candidates from Sun Yat-sen University(for Dr.JLC)
文摘Background:It remains unclear what the antiviral therapy affects disease-free survival(DFS) and overall survival(OS)of patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC) at different tumor stages and baseline HBV DNA levels.In this study,we analyzed the association of antiviral treatment with DFS and OS based on the stratification of baseline HBV DNA load in early-stage(stages Ⅰ and Ⅱ) HCC patients.Methods:We included 445 patients with early-stage HBV-related HCC who underwent curative resection,and then classified them into four subgroups based on baseline HBV DNA load and antiviral therapy stratification.The KaplanMeier and Cox regression analyses were performed to determine the association of clinical characteristics with survival.Results:The median follow-up period was 74 months.For all patients,cumulative OS rates in the antiviral group were significantly higher than those in the non-antiviral group(log-rank test,P = 0.023),whereas no significant differences in DFS rates were observed.High baseline HBV DNA level was a risk factor associated with short DFS and OS in all patients.In patients with baseline HBV DNA levels ≥2000 lU/mL,antiviral treatment was significantly associated with prolonged DFS and OS(log-rank test,P = 0.041 and 0.001,respectively).In patients with HBV DNA levels <2000 lU/mL or undetectable,antiviral treatment did not show a significant benefit in prolonging DFS and OS.Conclusions:High baseline HBV DNA levels are associated with poor prognosis in the patients with early-stage HCC,and the antiviral treatment could generate survival benefits for the patients.Therefore,antiviral treatment should be given for these patients.However,the effect of antiviral treatment on the patients with low viral load remains unclear,and further investigation is warranted.
基金financially supported by the Second Tibetan Plateau Scientific Expedition and Research (2019QZKK0801)the National Natural Science Foundation of China (NSFC programs 41772088, 41773042 and 41773043)the Geological Survey Project (DD20190001).
文摘1.Objectives The porphyry copper deposits (PCD) are usually hosted in a multistage intrusive complex but only causallyrelated tospecific magma of high oxidation state and water content. The copper enrichment of the porphyry system is caused by accumulation during magmatic differentiation (Hou ZQ et al., 2015). Thus, study on magmatic evolution and Cu mineralization process is important for understanding the formation of PCD.
