Tuberculosis remains a public health threat of global proportions.Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis,the causative agent of tuberculosis....Tuberculosis remains a public health threat of global proportions.Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis,the causative agent of tuberculosis.Siderophores are critical molecules for iron acquisition under iron-limiting conditions and,as a very efficient pathogen,M.tuberculosis has evolved elaborate siderophores knowledge of which is being intensively translated into clinical practice.This paper summarizes the structures,types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.展开更多
基金supported by the National Key Infectious Disease Project(No.2008ZX10003-006)National Natural Science Foundation(Grant No.81071316)+2 种基金Excellent PhD Thesis Fellowship of Southwest University(Nos.kb2009010 and ky2009009)the Fundamental Research Fund for the Central Universities(No.XDJK2009A003)Natural Science Foundation Project of CQ CSTC(No.2010BB5002)。
文摘Tuberculosis remains a public health threat of global proportions.Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis,the causative agent of tuberculosis.Siderophores are critical molecules for iron acquisition under iron-limiting conditions and,as a very efficient pathogen,M.tuberculosis has evolved elaborate siderophores knowledge of which is being intensively translated into clinical practice.This paper summarizes the structures,types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.
