This consensus was compiled by first-line clinical experts in the field of pain medicine and was organized by the Chinese Association for the Study of Pain.To reach this consensus,we consulted a wide range of opinions...This consensus was compiled by first-line clinical experts in the field of pain medicine and was organized by the Chinese Association for the Study of Pain.To reach this consensus,we consulted a wide range of opinions and conducted indepth discussions on the mechanism,indications,contraindications,operational specifications and adverse reactions of ozone iatrotechnique in the treatment of pain disorders.We also referred to related previous preclinical and clinical studies published in recent years worldwide.The purpose of this consensus is to standardize the rational application of ozone iatrotechnique in pain treatment,to improve its efficacy and safety and to reduce and prevent adverse reactions and complications in this process.展开更多
A bio-safe dengue control strategy is to use Wolbachia,which can induce incomplete cytoplasmic incompatibility(CI)and reduce the mating competitiveness of infected males.In this work,we formulate a delay differential ...A bio-safe dengue control strategy is to use Wolbachia,which can induce incomplete cytoplasmic incompatibility(CI)and reduce the mating competitiveness of infected males.In this work,we formulate a delay differential equation model,including both the larval and adult stages of wild mosquitoes,to assess the impacts of CI intensityξand mating competitivenessθof infected males on the suppression efficiency.Our analysis identifies a CI intensity thresholdξ*below which a successful suppression is impossible.Whenξ≥ξ*,the wild population will be eliminated ultimately if the releasing level exceeds the release amount threshold R*uniformly.The dependence of R*onξandθ,and the impact of temperature on suppression are further exhibited through numerical examples.Our analyses indicate that a slight reduction ofξis more devastating than significantly decrease ofθin the suppression efficiency.To suppress more than 95%wild mosquitoes during the peak season of dengue in Guangzhou,the optimal starting date for releasing is sensitive toξbut almost independent ofθ.One percent reduction ofξfrom 1 requires at least one week earlier in the optimal releasing starting date from 7 weeks ahead of the peak season of dengue.展开更多
文摘This consensus was compiled by first-line clinical experts in the field of pain medicine and was organized by the Chinese Association for the Study of Pain.To reach this consensus,we consulted a wide range of opinions and conducted indepth discussions on the mechanism,indications,contraindications,operational specifications and adverse reactions of ozone iatrotechnique in the treatment of pain disorders.We also referred to related previous preclinical and clinical studies published in recent years worldwide.The purpose of this consensus is to standardize the rational application of ozone iatrotechnique in pain treatment,to improve its efficacy and safety and to reduce and prevent adverse reactions and complications in this process.
基金supported by the National Natural Science Foundation of China(Nos.12026222,12071095)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT 16R16)by the Natural Science Foundation of Guangdong Province(No.2017A030310597)。
文摘A bio-safe dengue control strategy is to use Wolbachia,which can induce incomplete cytoplasmic incompatibility(CI)and reduce the mating competitiveness of infected males.In this work,we formulate a delay differential equation model,including both the larval and adult stages of wild mosquitoes,to assess the impacts of CI intensityξand mating competitivenessθof infected males on the suppression efficiency.Our analysis identifies a CI intensity thresholdξ*below which a successful suppression is impossible.Whenξ≥ξ*,the wild population will be eliminated ultimately if the releasing level exceeds the release amount threshold R*uniformly.The dependence of R*onξandθ,and the impact of temperature on suppression are further exhibited through numerical examples.Our analyses indicate that a slight reduction ofξis more devastating than significantly decrease ofθin the suppression efficiency.To suppress more than 95%wild mosquitoes during the peak season of dengue in Guangzhou,the optimal starting date for releasing is sensitive toξbut almost independent ofθ.One percent reduction ofξfrom 1 requires at least one week earlier in the optimal releasing starting date from 7 weeks ahead of the peak season of dengue.
