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Predicting the International Roughness Index of JPCP and CRCP Rigid Pavement:A Random Forest(RF)Model Hybridized with Modified Beetle Antennae Search(MBAS)for Higher Accuracy
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作者 Zhou Ji Mengmeng Zhou +1 位作者 Qiang Wang jiandong huang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期1557-1582,共26页
To improve the prediction accuracy of the International Roughness Index(IRI)of Jointed PlainConcrete Pavements(JPCP)and Continuously Reinforced Concrete Pavements(CRCP),a machine learning approach is developed in this... To improve the prediction accuracy of the International Roughness Index(IRI)of Jointed PlainConcrete Pavements(JPCP)and Continuously Reinforced Concrete Pavements(CRCP),a machine learning approach is developed in this study for the modelling,combining an improved Beetle Antennae Search(MBAS)algorithm and Random Forest(RF)model.The 10-fold cross-validation was applied to verify the reliability and accuracy of the model proposed in this study.The importance scores of all input variables on the IRI of JPCP and CRCP were analysed as well.The results by the comparative analysis showed the prediction accuracy of the IRI of the newly developed MBAS and RF hybrid machine learning model(RF-MBAS)in this study is higher,indicated by the RMSE and R values of 0.2732 and 0.9476 for the JPCP as well as the RMSE and R values of 0.1863 and 0.9182 for the CRCP.The accuracy of this obtained result far exceeds that of the IRI prediction model used in the traditional Mechanistic-Empirical Pavement Design Guide(MEPDG),indicating the great potential of this developed model.The importance analysis showed that the IRI of JPCP and CRCP was proportional to the corresponding input variables in this study,including the total joint faulting cumulated per KM(TFAULT),percent subgrade material passing the 0.075-mm Sieve(P_(200))and pavement surface area with flexible and rigid patching(all Severities)(PATCH)which scored higher. 展开更多
关键词 Cement pavement JPCP CRCP RF-MBAS IRI
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Advanced Machine Learning Methods for Prediction of Blast-Induced Flyrock Using Hybrid SVR Methods
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作者 Ji Zhou Yijun Lu +3 位作者 Qiong Tian Haichuan Liu Mahdi Hasanipanah jiandong huang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第8期1595-1617,共23页
Blasting in surface mines aims to fragment rock masses to a proper size.However,flyrock is an undesirable effect of blasting that can result in human injuries.In this study,support vector regression(SVR)is combined wi... Blasting in surface mines aims to fragment rock masses to a proper size.However,flyrock is an undesirable effect of blasting that can result in human injuries.In this study,support vector regression(SVR)is combined with four algorithms:gravitational search algorithm(GSA),biogeography-based optimization(BBO),ant colony optimization(ACO),and whale optimization algorithm(WOA)for predicting flyrock in two surface mines in Iran.Additionally,three other methods,including artificial neural network(ANN),kernel extreme learning machine(KELM),and general regression neural network(GRNN),are employed,and their performances are compared to those of four hybrid SVR models.After modeling,the measured and predicted flyrock values are validated with some performance indices,such as root mean squared error(RMSE).The results revealed that the SVR-WOA model has the most optimal accuracy,with an RMSE of 7.218,while the RMSEs of the KELM,GRNN,SVR-GSA,ANN,SVR-BBO,and SVR-ACO models are 10.668,10.867,15.305,15.661,16.239,and 18.228,respectively.Therefore,combining WOA and SVR can be a valuable tool for accurately predicting flyrock distance in surface mines. 展开更多
关键词 Flyrock induced by blasting optimization algorithms SVR GRNN
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Evaluating the Clogging Behavior of Pervious Concrete(PC)Using the Machine Learning Techniques 被引量:1
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作者 jiandong huang Jia Zhang Yuan Gao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2022年第2期805-821,共17页
Pervious concrete(PC)is at risk of clogging due to the continuous blockage of sand into it during its service time.This study aims to evaluate and predict such clogging behavior of PC using hybrid machine learning tec... Pervious concrete(PC)is at risk of clogging due to the continuous blockage of sand into it during its service time.This study aims to evaluate and predict such clogging behavior of PC using hybrid machine learning techniques.Based on the 84 groups of the dataset developed in the earlier study,the clogging behavior of the PC was determined by the algorithm combing the SVM(support vector machines)and particle swarm optimization(PSO)methods.The PSO algorithm was employed to adjust the hyperparameters of the SVM and verify the performance using 10-fold cross-validation.The predicting results of the developed model were assessed by the coefficient of determination(R)and root mean square error(RMSE).The importance of the influential variables on the clogging behavior of PC was evaluated as well.The results showed that the PSO algorithm can effectively adjust the hyperparameters of the SVM model and can be used to construct the predictive model for the clogging behavior of the PC.The combined algorithm has the advantage of higher reliability and validity than the random hyperparameters selection.For the verification process,the developed model was able to obtain values of 0.9469 and 1.8148 for the R and RMSE,showing that the developed machine learning model can accurately be used to evaluate and predict the clogging behavior of the PC,guiding the mix-design of PC from the perspective of durability.The size of the clogging sand is the most important parameter and the thickness of the sample is the least significant factor affecting the clogging behavior.The proportions of the smallest aggregate size and largest aggregate size are the two most important design parameters of concrete with the consideration of the relatively higher importance scores,showing these two aggregates should be given special attention in future PC design for anti-clogging purposes. 展开更多
关键词 Clogging behavior pervious concrete SVM PSO
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Current Trend of Metagenomic Data Analytics for Cyanobacteria Blooms
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作者 jiandong huang Huiru (Jane) Zheng Haiying Wang 《Journal of Geoscience and Environment Protection》 2017年第6期198-213,共16页
Cyanobacterial harmful algal blooms are a major threat to freshwater eco-systems globally. To deal with this threat, researches into the cyanobacteria bloom in fresh water lakes and rivers have been carried out all ov... Cyanobacterial harmful algal blooms are a major threat to freshwater eco-systems globally. To deal with this threat, researches into the cyanobacteria bloom in fresh water lakes and rivers have been carried out all over the world. This review presents an overlook of studies on cyanobacteria blooms. Conventional studies mainly focus on investigating the environmental factors influencing the blooms, with their limitation in lack of viewing the microbial community structures. Metagenomics study provides insight into the internal community structure of the cyanobacteria at the blooming, and there are researchers reported that sequence data was a better predictor than environmental factors. This further manifests the significance of the metagenomic study. However, large number of the latter appears to be confined only to present snapshoot of the microbial community diversity and structure. This type of investigation has been valuable and important, whilst an effort to integrate and coordinate the conventional approaches that largely focus on the environmental factors control, and the Metagenomics approaches that reveals the microbial community structure and diversity, implemented through machine learning techniques, for a holistic and more comprehensive insight into the cause and control of Cyanobacteria blooms, appear to be a trend and challenge of the study of this field. 展开更多
关键词 CYANOBACTERIA BLOOMS Harmful ALGAL METAGENOMICS Machine Learning Environmental Factors Next Generation Sequencing Techniques (NGS) 16S rRNA Fresh Water Ecosystem LAKES
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Nonlinear Refraction of Peripheral-Substituted Zinc Phthalocyanines Investigated by Nanosecond and Picose-cond Z Scans
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作者 Yunjing Li Timothy M Pritchett +2 位作者 jiandong huang Meirong Ke Wenfang Sun 《Optics and Photonics Journal》 2011年第2期70-74,共5页
The singlet and triplet excited-state refraction cross-sections of dimethyl sulfoxide (DMSO) solutions of ten zinc phthalocyanine derivatives with mono-or tetra-peripheral substituents at 532 nm were obtained by simul... The singlet and triplet excited-state refraction cross-sections of dimethyl sulfoxide (DMSO) solutions of ten zinc phthalocyanine derivatives with mono-or tetra-peripheral substituents at 532 nm were obtained by simultaneous fitting of closed-aperture Z scans with both nanosecond and picosecond pulse widths. Self-focusing of both nanosecond and picosecond laser pulses was observed in all complexes at 532-nm wavelength. The complexes with tetra-substituents at the ?-position exhibit relatively larger refraction cross-sections than the other complexes. The wavelength dependence of the singlet refraction cross-section of a representative complex was observed to be non-monotonic in the range of 470 - 550 nm. 展开更多
关键词 Nonlinear REFRACTION Zinc PHTHALOCYANINE Z Scan EXCITED-STATE REFRACTION CROSS-SECTION Wavelength Dispersion
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合成微生物群落的构建与应用 被引量:14
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作者 陈沫先 韦中 +3 位作者 田亮 谭扬 黄建东 戴磊 《科学通报》 EI CAS CSCD 北大核心 2021年第3期273-283,共11页
自然界中微生物群落的生态网络结构非常复杂,并且难以进行可重复、可控的扰动实验.在实验室里通过“自下而上”的方式构建起来的合成群落具有适中的复杂度和较高的可控性,可以作为数学模型和复杂生态系统研究之间的桥梁.合成微生物群落... 自然界中微生物群落的生态网络结构非常复杂,并且难以进行可重复、可控的扰动实验.在实验室里通过“自下而上”的方式构建起来的合成群落具有适中的复杂度和较高的可控性,可以作为数学模型和复杂生态系统研究之间的桥梁.合成微生物群落的研究方法遵循“设计-构建-测试-学习”为核心的合成生物学理念,以人工设计和构建的群落为实验对象,结合定量模型和基因组测序等组学技术,探索微生物生态学的基本规律.在应用方面,基于合成群落的研究对于如何控制和改造复杂的微生物生态系统具有重要的指导意义,目标是通过构建具有可控功能和稳定性的微生物群落来解决人体健康、农业和工业生产、环境治理等重要问题. 展开更多
关键词 合成微生物群落 数学模型 高通量测序 相互作用
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自动化合成生物技术与工程化设施平台 被引量:14
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作者 唐婷 付立豪 +7 位作者 郭二鹏 张振坤 王子宁 马辰飞 张智彧 张建志 黄建东 司同 《科学通报》 EI CAS CSCD 北大核心 2021年第3期300-309,共10页
合成生物学采用工程化设计理念,对生物体进行有目标的设计、改造,甚至从头合成具有特定功能的“人造生命”,用于探索生命活动规律和进行生物技术创新.由于生命系统高度复杂,人工设计的合成生命体很难完全按照预期工作,往往需要长时间的... 合成生物学采用工程化设计理念,对生物体进行有目标的设计、改造,甚至从头合成具有特定功能的“人造生命”,用于探索生命活动规律和进行生物技术创新.由于生命系统高度复杂,人工设计的合成生命体很难完全按照预期工作,往往需要长时间的反复调谐.目前,“试错”过程主要依靠研究者手动完成,存在通量低、重复性差、迭代慢等局限.针对这一难题,自动化合成生物技术通过低成本、多循环地完成海量工程试错性实验,提高研究通量和效率,大幅增加实验设计的复杂度和系统性,从而快速实现特定功能,揭示人工生命体的设计原理.近年来,在合成生物学“设计-构建-测试-学习”的各个研究环节,自动化技术正在以前所未有的速度加速发展.与此对应,在全球范围内已建成或在建多个大型工程化平台,用于支撑相关研究和应用.本文旨在对自动合成生物技术的关键要素进行总结,并对合成生物研究基础设施的发展情况和未来方向进行讨论. 展开更多
关键词 合成生物学 自动化 高通量 生物铸造厂 云端实验室 DNA组装
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代谢工程改造酿酒酵母底盘细胞 被引量:8
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作者 张云丰 何丹 +2 位作者 卢欢 黄建东 罗小舟 《科学通报》 EI CAS CSCD 北大核心 2021年第3期310-318,共9页
酿酒酵母是合成多种天然产物的微生物细胞工厂,合理利用酿酒酵母底盘细胞内源的代谢途径可生产高附加值的生物医药、食品保健和精细化学品类产物.如何精细调控和优化酿酒酵母胞内代谢流是实现目标化学物高产量、高产率和高转化的关键问... 酿酒酵母是合成多种天然产物的微生物细胞工厂,合理利用酿酒酵母底盘细胞内源的代谢途径可生产高附加值的生物医药、食品保健和精细化学品类产物.如何精细调控和优化酿酒酵母胞内代谢流是实现目标化学物高产量、高产率和高转化的关键问题.乙酰辅酶A是中心代谢和天然产物合成的基本前体,精细调控乙酰辅酶A的合成是实现目标化合物高产的重要策略;改造酿酒酵母的甲羟戊酸途径,引入外源途径酶,表达萜类合成酶生产不同种类的萜类化合物;优化脂肪酸合成途径合成特定链长的脂肪酸及脂肪酸衍生物.本文总结了强化酿酒酵母中乙酰辅酶A积累的代谢工程策略,重构甲羟戊酸途径、脂肪酸途径从头合成天然萜类化合物和脂肪酸衍生物的研究进展,为利用酿酒酵母底盘细胞生产天然产物的相关研究提供代谢工程改造策略. 展开更多
关键词 酿酒酵母 合成生物学 乙酰辅酶A 萜类 脂肪酸
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合成生物学在活体功能材料构建上的应用 被引量:4
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作者 张曦 李鹏程 +1 位作者 黄建东 戴卓君 《科学通报》 EI CAS CSCD 北大核心 2021年第3期341-346,共6页
材料是人类赖以生存与发展的物质基础,代表了一个时代科学技术成果的最前沿.近年来飞速发展的合成生物学,通过改进现有系统或构建全新的生物体系,极大地促进了对生物本身的了解,拓宽了生命科学的应用范围.将构建的生物体系进一步结合材... 材料是人类赖以生存与发展的物质基础,代表了一个时代科学技术成果的最前沿.近年来飞速发展的合成生物学,通过改进现有系统或构建全新的生物体系,极大地促进了对生物本身的了解,拓宽了生命科学的应用范围.将构建的生物体系进一步结合材料科学中的设计工具及方法,便诞生了活体功能材料这一概念及领域.与传统材料不同,活体功能材料以活体细胞为结构单体组装材料,活体细胞本身成为材料的工程化设计工具以及技术设想和实现途径的基本单元.将编程后的工程活细胞组装、裁剪成具有生物系统特性的活体功能材料,将活体细胞的自我修复能力等特性融入材料,进一步拓展了原有材料的性能.本文将着重介绍活体功能材料的产生、发展及近年来取得的相关成果,在此基础上对活体功能材料未来的发展进行展望. 展开更多
关键词 合成生物学 活体功能材料 基因线路 生物材料
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定量工程生物学的化学蛋白质组学支撑性技术 被引量:3
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作者 王蕾 黄建东 +2 位作者 杨舒心 黄术强 李楠 《科学通报》 EI CAS CSCD 北大核心 2021年第3期356-366,共11页
定量工程生物学是一门前沿交叉学科,通过设计-合成-测试-学习-再设计路线将不同的生物元器件组合,形成可以执行特定功能的基因线路,再经过不断优化获得稳定的、可控的基因线路,最后将设计优化后的线路引入不同的生命体,以达到预设的目的... 定量工程生物学是一门前沿交叉学科,通过设计-合成-测试-学习-再设计路线将不同的生物元器件组合,形成可以执行特定功能的基因线路,再经过不断优化获得稳定的、可控的基因线路,最后将设计优化后的线路引入不同的生命体,以达到预设的目的.这种变革性的方法可以创建一些能够灵敏感知和响应各种环境的工程系统,但在其中的功能检测环节,化学蛋白质组学技术则成为了测试工程改造生物功能和探究其作用机制的重要工具.随着以非天然氨基酸嵌入、生物正交化学、高分辨率质谱等技术为手段的化学蛋白质组学方法的发展,在复杂环境中解析工程生物的蛋白质组时空动力学变化成为可能,为探究工程改造菌或工程改造细胞的工作原理及其在生物体内的作用机制提供了必要的技术支撑,也为定量工程生物学研究中所需的深度功能测试提供了有效方法.本文主要是概述化学蛋白质组学技术在定量工程生物学研究中的潜在应用. 展开更多
关键词 定量工程生物学 基因线路 化学蛋白质组学 生物正交化学
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以非天然核酸为遗传物质的人工生命构建 被引量:2
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作者 白艳芬 聂朋 +8 位作者 熊成鹤 温骏林 甘海云 马晴 胡政 李雪飞 于涛 黄建东 梅辉 《科学通报》 EI CAS CSCD 北大核心 2021年第3期347-355,共9页
合成生物学/工程生物学通过设计、搭建生物部件甚至生物系统来构建具有新功能的人工生命.其研究内容主要分为3个层次:(1)将现有的天然生物模块进行设计和组装,构建不同于天然存在的调控网络,从而实现新功能;(2)通过人工基因组DNA的全合... 合成生物学/工程生物学通过设计、搭建生物部件甚至生物系统来构建具有新功能的人工生命.其研究内容主要分为3个层次:(1)将现有的天然生物模块进行设计和组装,构建不同于天然存在的调控网络,从而实现新功能;(2)通过人工基因组DNA的全合成进行新生命的构建;(3)通过化学合成部件(修饰核酸、蛋白质、脂类等)创建全新的生物系统乃至生命体.第3个层次的研究也称为化学合成生物学,本文主要集中讨论化学合成生物学中将非天然核酸替代DNA作为遗传物质从而构建人工生命的研究,简要介绍了非天然核酸化学修饰对其遗传物质功能的影响,及以其为基础的人工生命构建的研究现状.这将为我们探讨生命起源、进化甚至外星生命等问题提供新的思路. 展开更多
关键词 合成生物学 非天然核酸 遗传物质 人工生命 新生命形式
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