Research Progress of Continuous Blood Purification in the Treatment of Severe Sepsis in Children

Pediatric sepsis is the most common disease in pediatric critical illness,because the main reason for the disease is that children's immune level is not high or the immune system is not perfect,when children's lung,abdominal cavity and blood system are infected,it will cause systemic inflammation and immune dysfunction.Early clinical symptoms are mainly irregular and intermittent fever.When the disease develops to severe sepsis,the children will suffer from acute heart failure,oliguria,respiratory alkalosis and even multiple organ failure.The incidence of death is high.It is reported that the incidence rate of sepsis in children can reach 0.3%,and the mortality rate is 50%.High incidence rate,high mortality rate and high treatment cost are the biggest problems in the pediatric field.In the past,the clinical hope of clearing away heat and toxin,promoting blood circulation and removing stasis,strengthening inflammation and other methods in traditional Chinese medicine,but the treatment effect is not ideal.With the improvement of modem medical understanding of sepsis,continuous blood purification therapy is introduced into the treatment of children with severe sepsis.In order to further explore the effect of continuous blood purification in the treatment of children with severe sepsis,the author summarizes the clinical practice experience and relevant literature,hoping to provide reference for relevant medical staff。

Progress and prospects in chitosan derivatives:Modification strategies and medical applications

Chitosan(CS)is the only natural alkaline polysaccharide originated from deacetylation of chitin that is the main component of shell from marine organisms.It has great potential medical application due to its broad-spectrum antimicrobial activity and good water solubility originated from its protonated amino groups under acidic condition and abundant hydroxyl groups.However,unprotonated NH_(2)group of CS leads to its poor solubility under physiological condition and limits its diverse applications.Therefore,it is highly necessary to summarize the modification strategies of CS derivatives systematically to help researchers select the most appropriate strategies for their specific applications.Herein,we have summarized the modification strategies of CS derivatives for improving their antimicrobial activity,water solubility,biocompatibility,and mechanical property by chemical reaction and physical integration.And then we have reviewed the CS derivatives in hydrogels,nanoparticles,or coatings for medical application in wound dressing,drug delivery,medical implant.Last but not the least,we have put forward the future perspectives of deep studies about structure-activity relationship and clinical applications of CS derivatives.

Non‑Leaching,Rapid Bactericidal and Biocompatible Polyester Fabrics Finished with Benzophenone Terminated N‑halamine

Pathogenic bacteria can proliferate rapidly on porous fabrics to form bacterial plaques/bioflms,resulting in potential sources of cross-transmissions of diseases and increasing cross-infection in public environments.Many works on antibacterial modifcation of cotton fabrics have been reported,while very few works were reported to endow poly(ethylene terephthalate)(PET)fabrics with non-leaching antibacterial function without compromising their innate physicochemical properties though PET is the most widely used fabric.Therefore,it is urgent to impart the PET fabrics with non-leaching antibacterial activity.Herein,a novel N-halamine compound,1-chloro-3-benzophenone-5,5-dimethylhydantoin(Cl-BPDMH),was developed to be covalently bonded onto PET fabrics,rendering non-leaching antibacterial activity while negligible cytotoxicity based on contact-killing principle.Bacterial was easily adhered to Cl-BPDMH fnished PET fabrics,and then it was inactivated quickly within 10 s.Furthermore,the breaking strength,breaking elongation,tearing strength,water vapor permeability,air permeability and whiteness of Cl-BPDMH fnished PET fabrics were improved obviously compared to raw PET fabrics.Hence,this work developed a facile approach to fabricate multifunctional synthetic textiles to render outstanding and rapid bactericidal activity without compromising their physicochemical properties and biocompatibility.