Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and pra...Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary.展开更多
A one-pot approach to ethyl 1,4,5-triaryl-lH-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficie...A one-pot approach to ethyl 1,4,5-triaryl-lH-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficiently provided the enolized lithium salts of ethyl 2,4-dioxo-3,4-diarylbutanoates, which in situ reacted with arylhydrazine hydrochlorides via a hydrochloric acid-promoted Knorr reaction to produce the exquisite triarylpyrazole-3- carboxylates. The procedure promises a convenient access to this highly crowded framework for drug discovery.展开更多
The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-d...The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-diketoesters via a sequential Knorr-pyrazole reaction to deliver a variety of aryl-substituted ethyl 1-(thiazol-2-yl)-1Hpyrazole-3-carboxylates in a one-pot fashion with moderate to high yields.The key intermediates 4-aryl-2,4-diketoesters,existing as its enolic lithium salt,were synthesized in situ by a high-yield tert-BuOLi-mediated Claisen condensation of alkylphenones and diethyl oxalate.This class of elegant molecule comprises aryl groups on the two different heterocyclic cores,and the configurations of two representative molecules were determined by single crystal X-ray crystallography.展开更多
基金supported by 2016 Shandong province undergraduate universities teaching reform research project:Exploration and practice of teaching reform and innovation mode of higher education based on MOOC (No.B2016Z018),Research and application of blended teaching mode based on MOOC+SPOCs+ flipped classroom(No.B2016Z020)teaching research project of 2016 Postgraduate Education Innovation Project in Shandong Province:Study on multidimensional education quality evaluation system for professional degree graduate students (SDYZ1603),research project of higher computer education:"Study of Staged Practice Education and Innovation Ability Development"(ER2016009),the Chinese National Supervisory Committee for the Education of Master of Engineering under Grant(No.2016-ZDn-6),Shandong Provincial Department of Education under Grant(No.SDYY14003) and teaching research project of Harbin Institute of Technology at Weihai (BK201602) as well
文摘Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary.
基金The authors are grateful to the National Natural Science Foundation of China (Nos.21176074 and 21171093) for financial support
文摘A one-pot approach to ethyl 1,4,5-triaryl-lH-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficiently provided the enolized lithium salts of ethyl 2,4-dioxo-3,4-diarylbutanoates, which in situ reacted with arylhydrazine hydrochlorides via a hydrochloric acid-promoted Knorr reaction to produce the exquisite triarylpyrazole-3- carboxylates. The procedure promises a convenient access to this highly crowded framework for drug discovery.
基金The authors are grateful to the National Natural Science Foundation of China(Nos.21176074 and 21171093)for financial support.
文摘The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-diketoesters via a sequential Knorr-pyrazole reaction to deliver a variety of aryl-substituted ethyl 1-(thiazol-2-yl)-1Hpyrazole-3-carboxylates in a one-pot fashion with moderate to high yields.The key intermediates 4-aryl-2,4-diketoesters,existing as its enolic lithium salt,were synthesized in situ by a high-yield tert-BuOLi-mediated Claisen condensation of alkylphenones and diethyl oxalate.This class of elegant molecule comprises aryl groups on the two different heterocyclic cores,and the configurations of two representative molecules were determined by single crystal X-ray crystallography.
