Polarization and fundamental sensitivity of 39K(133Cs)-85Rb-21Ne co-magnetometers

The hybrid optical pumping spin exchange relaxation free(HOPSERF)atomic co-magnetometers make ultrahigh sensitivity measurement of inertia achievable.The wall relaxation rate has a big effect on the polarization and fundamental sensitivity for the co-magnetometer,but it is often neglected in the experiments.However,there is almost no work about the systematic analysis of the influence factors on the polarization and the fundamental sensitivity of the HOPSERF co-magnetometers.Here we systematically study the polarization and the fundamental sensitivity of 39K-85Rb-21Ne and 133Cs-85Rb-21Ne HOPSERF co-magnetometers with low polarization limit and the wall relaxation rate.The 21Ne number density,the power density and wavelength of pump beam will affect the polarization greatly by affecting the pumping rate of the pump beam.We obtain a general formula on the fundamental sensitivity of the HOPSERF co-magnetometers due to shot-noise and the fundamental sensitivity changes with multiple systemic parameters,where the suitable number density of buffer gas and quench gas make the fundamental sensitivity highest.The fundamental sensitivity 7.5355×10^-11 rad·s^-1·Hz^-1/2 of 133Cs-85Rb-21Ne co-magnetometer is higher than the ultimate theoretical sensitivity 2×10^-10 rad·s^-1·Hz^-1/2 of K-21Ne co-magnetometer.

The connection between meridians and physiological functions:A quantum principle

In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human body.They are regarded to be the channels connecting the internal organs with the body surface and various parts of the body.Although there are many studies and doctrines trying to reveal the nature of meridians for their validation in TCM,the mechanism underlying the meridians remains unclear.Herein,based on our macroscopic quantum state concept of ion channels(i.e.,sub-nanometer scale channels),we propose a quantum principle of meridians.The acupoints and organ symptom are in a macroscopic coherence state of the ion channels in meridians.By applying TCM treatments(e.g.,TCM massage,acupuncture,moxibustion,and electroacupuncture)on the acupoint,the corresponding organ symptom could be well regulated with help of quantum meridian state.

基于TOA和TDTOA的增广状态脉冲星组合导航误差抑制方法

脉冲星导航是一种极具潜力的深空自主导航技术,通常采用脉冲到达时间(time of arrival,TOA)作为量测信息.但脉冲星星历误差和星载原子钟误差等系统误差对导航性能有显著影响.为了解决上述问题,提出了一种基于TOA和时间差分TOA(TDTOA)的增广状态脉冲星组合导航误差抑制方法,通过将每个脉冲星的星历误差和时钟误差增加到状态向量,并利用TOA和TDTOA量测值对其进行估计和校正.仿真结果表明,该方法提高了脉冲星星历误差和时钟误差的可观测性,有效地消除了这些系统误差的影响,导航精度相比传统脉冲星导航提高了29%.

Optical Rotation Detection for Atomic Spin Precession Using a Superluminescent Diode

A superluminescent diode (SLD) as an alternative of laser is used to detect optical rotation for atomic spin precession. A more uniform Gauss configuration without additional beam shaping and a relatively high power of the SLD have a potential for atomic magnetometers, which is demonstrated in theory and experiments. In addition, the robustness and compactness enable a more practical way for optical rotation detections, especially for applications in magnetoencephalography systems.

Mutation profiling of 16 candidate genes in de novo acute myeloid leukemia patients

This retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes in de novo acute myeloid leukemia (AML) patients. A total of 259 patients who were diagnosed of de novo AML were enrolled in this study. Mutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencing. We identified at least 1 mutation in 199 of the 259 samples (76.8%), and 2 or more mutations in 31.7% of samples. FLT3-ITD was the most common mutated gene (16.2%, 42/259), followed by CEBPA (15.1%, 39/259), NRAS (14.7%, 38/259), and NPM1 (13.5%, 35/259). Concurrence was observed in 97.1% of the NPM1 mutated cases and in 29.6% of the double mutated CEBPA cases. Distinct patterns of co-occurrence were observed for different hotspot mutations within the IDH2 gene: R140 mutations were associated with NPM1 and/or FLT3-ITD mutations, whereas R172 mutations co-occurred with DNMT3A mutations only. Concurrence was also observed in 86.6% of epigenetic regulation genes, most of which co-occurred with NPM1 mutations. The results showed certain rules in the mutation profiling and concurrence of AML patients, which was related to the function classification of genes. Defining the mutation spectrum and mutation pattern of AML will contribute to the comprehensive assessment of patients and identification of new therapeutic targets.

Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

Over the past two decades,biodegradable metals(BMs)have emerged as promising materials to fabricate temporary biomedical devices,with the purpose of avoiding potential side effects of permanent implants.In this review,we first surveyed the current status of BMs in neuroscience,and briefly summarized the representative stents for treating vascular stenosis.Then,inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents,we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke.For these novel applications,some key factors should also be considered in designing BM brain stents,including the anatomic features of the cerebral vasculature,hemodynamic influences,neuro-cytocompatibility and selection of alloying elements.This work may provide insights into the future design and fabrication of BM neurological devices,especially for brain stents.

Noise reduction and signal to noise ratio improvement in magneto-optical polarization rotation measurement

The measurement of an extremely small magneto-optical polarization rotation angle with high sensitivity is integral to many scientific and technological applications. In this Letter, we have presented a technique based on Faraday modulation combined with the optical differential method to measure an extremely small polari- zation rotation angle with high sensitivity. The theoretical and experimental results show that common mode noise is reduced appreciably and signal to noise ratio is enhanced. The effectiveness of this technique has been demonstrated by measuring the Verdet constant of terbium gallium garnet glass and measuring the small polari- zation rotation angle. A sensitivity of enhancement of one order of magnitude has been achieved using differ- ential detection based on Faraday modulation.