Alkylation of the ketimine 2 obtained from condensation of (+)-ketopinic acid and benzyla- mine with a variety of alkylating agents gives the products whose trends in diastereomeric excesses (1- 100% O. P.) appear to ...Alkylation of the ketimine 2 obtained from condensation of (+)-ketopinic acid and benzyla- mine with a variety of alkylating agents gives the products whose trends in diastereomeric excesses (1- 100% O. P.) appear to correlate with the structure and reactivity of electrophilic agents. Using excess n-butyl lithium and allylic or benzylic halides, β-alkylation occured.展开更多
The carbonyl addition of the pinanone ketimine derived from (+) or (-)-2-hydroxy-pinan- 3-one and benzylamine has been studied and the optically active α,β-substituted-β-aminoethanol deriva- tives were obtained in ...The carbonyl addition of the pinanone ketimine derived from (+) or (-)-2-hydroxy-pinan- 3-one and benzylamine has been studied and the optically active α,β-substituted-β-aminoethanol deriva- tives were obtained in good chemical yields (36.5-69.5%) with optical purity ranging from 1.4% to 99.9%.展开更多
基金The subject was supported by the National Natural Science Foundation of China
文摘Alkylation of the ketimine 2 obtained from condensation of (+)-ketopinic acid and benzyla- mine with a variety of alkylating agents gives the products whose trends in diastereomeric excesses (1- 100% O. P.) appear to correlate with the structure and reactivity of electrophilic agents. Using excess n-butyl lithium and allylic or benzylic halides, β-alkylation occured.
基金This project is supported by the National Natural Science Foundation of China
文摘The carbonyl addition of the pinanone ketimine derived from (+) or (-)-2-hydroxy-pinan- 3-one and benzylamine has been studied and the optically active α,β-substituted-β-aminoethanol deriva- tives were obtained in good chemical yields (36.5-69.5%) with optical purity ranging from 1.4% to 99.9%.
