To the Editor:Clinical symptom spectrum of paroxysmal nocturnal hemoglobinuria (PNH)is consisted of chronic intravascular hemolysis,hemoglobinuria,relative bone marrow failure,and the rarity of thrombosis.[1]The neuro...To the Editor:Clinical symptom spectrum of paroxysmal nocturnal hemoglobinuria (PNH)is consisted of chronic intravascular hemolysis,hemoglobinuria,relative bone marrow failure,and the rarity of thrombosis.[1]The neurological complications generated by PNH were almost exclusively a result of cerebral venous thrombosis.[1-3]However,moyamoya syndrome (MMS)secondary to PNH (PNH-MMS)is rarely described in the literature.[2-5]We report herein a case of PNH-MMS to raise the awareness of this disease in PNH patients presenting with acute neurological deficits.展开更多
To the Editor： Letrozole, a third-generation aromatase inhibitor （AlL is a relatively newer class of endocrine agents used in hormone-receptor-positive breast cancer Vascular thrombotic events, such as acute myocard...To the Editor： Letrozole, a third-generation aromatase inhibitor （AlL is a relatively newer class of endocrine agents used in hormone-receptor-positive breast cancer Vascular thrombotic events, such as acute myocardial infarction and acute cerebral infarction, in patients with breast cancer after initiation of letrozole therapy have been documented in the literature However, the impact of this adjuvant endocrine therapy on increasing tile risk of developing vascular tbrombotic events has been a controversial issue. Here, we report a rare case of a woman with breast cancer developing unilateral internal carotid artery （ICA） occlusion alier letrozole treatment.展开更多
文摘To the Editor:Clinical symptom spectrum of paroxysmal nocturnal hemoglobinuria (PNH)is consisted of chronic intravascular hemolysis,hemoglobinuria,relative bone marrow failure,and the rarity of thrombosis.[1]The neurological complications generated by PNH were almost exclusively a result of cerebral venous thrombosis.[1-3]However,moyamoya syndrome (MMS)secondary to PNH (PNH-MMS)is rarely described in the literature.[2-5]We report herein a case of PNH-MMS to raise the awareness of this disease in PNH patients presenting with acute neurological deficits.
文摘To the Editor： Letrozole, a third-generation aromatase inhibitor （AlL is a relatively newer class of endocrine agents used in hormone-receptor-positive breast cancer Vascular thrombotic events, such as acute myocardial infarction and acute cerebral infarction, in patients with breast cancer after initiation of letrozole therapy have been documented in the literature However, the impact of this adjuvant endocrine therapy on increasing tile risk of developing vascular tbrombotic events has been a controversial issue. Here, we report a rare case of a woman with breast cancer developing unilateral internal carotid artery （ICA） occlusion alier letrozole treatment.
