Effects of dezocine on postoperative stress response and immune function in patients with breast cancer

Objective: To investigate the effects of dezocine on postoperative stress response and immune function in patients with breast cancer. Methods: According to random data table method, a total of 80 patients who were scheduled for breast cancer radical surgery from September 2016 to May 2017 were divided into observation group and the control group, 40 cases in each group. The observation group gave intravenous injection of dezocine as an advanced analgesia 15 min before anesthesia induction, the control group given the same amount of sodium chloride injection. The levels of serum inflammatory factors and immune function were measured and compared between the two groups before and after operation. Results: The levels of angiotensin Ⅱ, renin, cortisol, aldosterone, CD3+, CD4+, CD8+and CD4+/CD8+ in the two groups before treatment were not statistically significant. The levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the two groups were increased at first and then decreased, which were significantly higher than those in the same group before operation at 1 d and 3 d;and the levels of angiotensin Ⅱ, renin, cortisol, aldosterone in the observation group were significantly lower than those in the control group after 1 d and 3 d, the difference was statistically significant. The levels of serum CD3+, CD4+ and CD4+/CD8+ in the two groups were decreased at first and then increased, which were significantly lower than those in the same group before operation at 1 d and 3 d;and the observation group levels were significantly higher than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The levels of serum CD8+ in the two groups were increased at first and decreased subquently, which were significantly higher than those in the same group before operation at 1 d and 3 d and the observation group levels were significantly lower than those in the control group after 1 d and 3 d, the above indicators were compared with the difference was statistically significant. The above indicators have restore to preoperative levels after 5 d. Conclusion: Dezocine can reduce the stress response in patients with perioperative breast cancer, improve the immune function of patients, which has important clinical value, so it is worth promoting.

Effects of dexmedetomidine on inflammatory response and oxidative stress in laparoscopic hysterectomy patients

Objective: To investigate the effect of dexmedetomidine on inflammatory response and oxidative stress in patients with laparoscopic total hysterectomy. Methods: Ninety patients with laparoscopic hysterectomy under general anesthesia were selected in our hospital from January 2015 to December 2016, and randomly divided into control group and observation group, Each group of 45 cases. The observation group was given dexmedetomidine, intravenous pump injection, The control group was given the same amount of saline in the same manner, followed by anesthesia induction. The hemodynamics, inflammatory factors and oxidative stress were monitored before anesthesia (T0), 30 min after the end of pneumoperitoneum (T1), after operation (T2) and at the end of 24 h (T3). Results: Compared with T0, T1, T2 and T3, the observation group of patients with MAP and HR levels were no significant difference;T3, the control group MAP and HR levels were not significantly different;T1 and T2, MAP and HR levels in the control group were significantly increased, And significantly higher than the observation group;Compared with T0, the levels of CRP, TNF-α and IL-1β in patients were significantly increased in T1, T2 and T3, but the levels of CRP, TNF-α and IL-1β in the observation group were significantly lower than those in the control group;Compared with T0, both groups of patients with H2O2 and MDA levels were significantly increased, TAS levels were significantly reduced, the difference was statistically significant, However, the levels of H2O2 and MDA in the observation group were significantly lower than those in the control group, the level of TAS was significantly higher than the control group. Conclusion:Laparoscopic hysterectomy increases the inflammatory response and oxidative stress in patients, while the use of dexmedetomidine can maintain hemodynamic stability in a certain extent, reduce the inflammatory response and reduce oxidative stress injury;it is worth of further clinical application.