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基于FAERS数据库的儿童使用氯雷他定不良事件信号挖掘与分析
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作者 翟亦斌 罗传璀 +5 位作者 曾真 蒋玲 李江萍 彭雯 李剑 杨亮 《药物流行病学杂志》 CAS 2023年第4期367-375,共9页
目的挖掘真实世界数据中儿童使用氯雷他定的不良事件(ADE)信号,发现其潜在的ADE类型,为合理用药提供依据。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库中2013年第1季度至2021年第2季度的ADE报告并筛选出儿童使用氯雷他定... 目的挖掘真实世界数据中儿童使用氯雷他定的不良事件(ADE)信号,发现其潜在的ADE类型,为合理用药提供依据。方法提取美国食品药品管理局不良事件报告系统(FAERS)数据库中2013年第1季度至2021年第2季度的ADE报告并筛选出儿童使用氯雷他定的报告,采用比例报告比值(PRR)法和报告比值比(ROR)法进行信号挖掘,使用《国际医学用语词典》(MedDRA)对ADE信号挖掘结果进行系统分类。结果经筛选后共纳入19237份报告,1738种ADE,信号186个,涉及系统/器官分类24个(各类损伤、中毒及操作并发症占22.49%),标准化MedDRA分析查询(SMQ)层级38个(用药错误占15.74%),药品说明书未收载的ADE较强信号包括眼睑松垂和广场恐怖症等。结论经PRR法和ROR法分析发现虽然儿童使用氯雷他定具有良好的安全性,但存在一定的用药错误,建议在临床用药中加强监护,严格按照药品说明书规定使用,提高药学服务质量,保障患儿用药安全、有效。 展开更多
关键词 氯雷他定 儿童用药 用药错误 数据挖掘 FAERS数据库 药物警戒
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Study on the trauma and stress level of the pelvic fracture treated by 3D printing combined with lateral rectus abdominis approach surgery
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作者 jiang-ping li Jin-Cai Wang +3 位作者 Jin-Xi Bai Guang-Yi Wen li-He Chen Can-Jun Zeng 《Journal of Hainan Medical University》 2017年第19期84-87,共4页
Objective: To study the trauma and stress level of the pelvic fracture treated by 3D printing combined with lateral rectus abdominis approach surgery. Methods: A total of 50 patients with pelvic fractures who were tre... Objective: To study the trauma and stress level of the pelvic fracture treated by 3D printing combined with lateral rectus abdominis approach surgery. Methods: A total of 50 patients with pelvic fractures who were treated in the hospital between July 2015 and Jun 2017 were collected anddivided into control group (n=25) and observation group (n=25) by random number table method. Control group underwent lateral rectus abdominis approach surgery, and the observation group received 3D printingcombined with lateral rectus abdominis approach surgery. The differences in perioperative inflammatory response, coagulation function and stress degree were compared between the two groups. Results: 24 h before surgery, the differences in inflammatory response, coagulation function and stress degree were not statistically significant between the two groups. 24 h after surgery, serum IL-1, TNF-α, CRP, FIB, D-D, Cor, AngⅡ and NE levels of both groups of patients were higher than those 24h before surgery, and serum IL-1, TNF-α, CRP, FIB, D-D, Cor, AngⅡ and NE levels of observation group were lower than those of control group. Conclusion: 3D printing combined with lateral rectus abdominis approach surgery can effectively reduce the degree of surgical trauma and reduce the systemic stress response in patients with pelvic fracture. 展开更多
关键词 PELVIC FRACTURE 3D PRINTING TRAUMA Stress
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