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Chemokines and their receptors in lung cancer progression and metastasis
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作者 Zeng-hui CHENG Yu-xin SHI +3 位作者 Min YUAN Dan XIONG jiang-hua zheng Zhi-yong ZHANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2016年第5期342-351,共10页
Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is stil... Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography (LDCT) scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ame- liorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. Chemo- kines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer. 展开更多
关键词 Lung cancer CHEMOKINES Tumor progression METASTASIS
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