Regenerative medicine refers to the possibility of replacing aged/daniaged cells with genetically similar young and functional cells to restore or establish normal function.Kartogenin(KGN),a small heterocyclic,drug-li...Regenerative medicine refers to the possibility of replacing aged/daniaged cells with genetically similar young and functional cells to restore or establish normal function.Kartogenin(KGN),a small heterocyclic,drug-like compound was discovered in 2012,which is strongly associated with regenerative medicine.KGN has been applied in many regenerative fields,including cartilage regeneration and protection,tendon-bone healing,wound healing,and limb devclopmcnt.KGN could facilitate cartilage repair,promote fonnation of cartilage-like transition zone in tendon-bone junctions,stimulate collagen synthesis for wound healing,and regulate limb development in a coordinated manner.Considering the related mechanism,filamin A/CBFβ/RUNX1,Ihh,and TGFβ/Smad pathways have been reported to involve KGN.Therefore,KGN is proven a promising agent in regenerative medicine;however,studies conducted on the effect of KGN are limited to date and not convictive for Iong-term use.Further studies are recommended to explore the long-term effect and poteniial molecular mechanisms of KGN.Our investigations may motivate researchers to expand its applications in different forms and fields.展开更多
基金the National Key R&D Program of China(No.2016YFC1100300,No.2017YFC0840100 and No.2017YFC0840106)the National Natural Science Foundation of China(No.81572108 and No.81772339)+5 种基金the Key Clinical Medicine Center of Shanghai(No.2017ZZ01006)the Sanming Project of Mcdicine in Shenzhen(No.SZSM20161207)the Shanghai Rising Star Project(No.18QB1400500)the Introduction Project of Clinical Medicine Expert Team for Suzhou(No.SZYJTD2017I4)CAS Key Laboratory of Nano-Bio Interface(No.17NBI01)State Key Laboratory of Molecular Engineering of Polymers(No.K2018-17).
文摘Regenerative medicine refers to the possibility of replacing aged/daniaged cells with genetically similar young and functional cells to restore or establish normal function.Kartogenin(KGN),a small heterocyclic,drug-like compound was discovered in 2012,which is strongly associated with regenerative medicine.KGN has been applied in many regenerative fields,including cartilage regeneration and protection,tendon-bone healing,wound healing,and limb devclopmcnt.KGN could facilitate cartilage repair,promote fonnation of cartilage-like transition zone in tendon-bone junctions,stimulate collagen synthesis for wound healing,and regulate limb development in a coordinated manner.Considering the related mechanism,filamin A/CBFβ/RUNX1,Ihh,and TGFβ/Smad pathways have been reported to involve KGN.Therefore,KGN is proven a promising agent in regenerative medicine;however,studies conducted on the effect of KGN are limited to date and not convictive for Iong-term use.Further studies are recommended to explore the long-term effect and poteniial molecular mechanisms of KGN.Our investigations may motivate researchers to expand its applications in different forms and fields.
