Study of Krypton Laser-Induced Choroidal Neovascularization in a Guinea Pig Model of High Anisometropia

Purpose:To investigate the association between high anisometropia and the area of choroidal neovascularization (CNV) induced by krypton laser in guinea pigs and better understand the pathogenesis and prevention of myopic CNV. Methods:.Nine 3-week old male guinea pigs with anisometropia > 6.00D were randomly assigned to three groups according to examination date after laser photocoagulation (7d, 14d and 28d). All animals underwent refraction. The eye with higher myopia was used as the experimental eye, and the other as the control eye..All eyes received repeated multi-wavelength krypton laser photocoagulation treatments (wavelength: 532 nm; laser power: 400 mW; spot diameter: 50 μm; exposure time: 0.1s). Fundus photography and indocyanine green angiography (ICGA) were performed. Afterwards, the animals were sacrificed immediately,.and the eyes were enucleated and processed for histopathologic examination and flat mounts. Results: CNV appeared at 7d after laser treatment. The area of CNV peaked at 14d, and decrease in area and the presence of scarring was noted at 28 d..CNV was present in 66.7% of eyes by ICGA at 14 d..CNV could be observed under light microscopy at all three time points..At 14 d,.flat mount showed the neovascular plexus around the lesion. Semi-quantitative analysis revealed that the area of CNV in treated eyes was greater than that of control eyes. Conclusion:.Since the mechanism of CNV in this study resembles that of CNV in pathological myopia, this model can be used to investigate the etiology, pathogenesis and treatment of CNV in pathological myopia.

Spatio-temporal Variation of PM_(2.5) in China from 1998 to 2016

With the rapid development of China's economy,people's demand for a healthy living environment is increasing,and air quality has gradually been widely concerned by all sectors of society.Using the big data of air quality monitoring from 1998 to 2016,based on the exploratory spatio-temporal analysis method,this paper explored the spatio-temporal evolution of PM_(2.5) at the national scale,and drew the following conclusions:①PM_(2.5) heavy pollution is mainly in central and eastern China,north and south China,and the pollution degree is relatively light in northwest and northeast China.Meanwhile,PM_(2.5) concentration in heavily polluted areas increased significantly over time,while PM_(2.5) concentration in low-polluted areas showed a long-term stable trend.②The number and area of cities with moderate and high PM_(2.5) pollution levels showed an inverted U-shaped curve from 1998 to 2016,and 2007 was the inflection point.③The spatial autocorrelation coefficient of PM_(2.5) is high over the years,and the spatial neighbor effect of PM_(2.5) is significant.The high-pollution clusters are mainly concentrated in the Beijing-Tianjin-Hebei region,the Yangtze River Delta and the Pearl River Delta,and the pollution concentration in these three regions has increased rapidly in recent years.It is necessary to focus on joint prevention and control.

Endometrial Carcinogenesis and Molecular Signaling Pathways

The Endometrial Cancer (EC) is the most common gynecologic malignancy that starts in the endometrium of women. Carcinogenesis of EC is associated with several critical regulatory molecules, which involve in different signaling pathways. A number of signaling pathways have been identified to be involved in the multiple-step development of EC, including PI3K/AKT/mTOR signaling pathway, WNT/β-catenin signal transduction cascades (including APC/β-catenin pathway), MAPK/ERK pathway, VEGF/VEGFR ligand receptor signaling pathway, ErbB signaling pathway, P53/P21 and P16INK4a/pRB signaling pathways. This review mainly focuses on the molecular signaling pathways relevant to human endometrial cancer and discusses those critical capabilities of transforming endometrial cells, including evading apoptosis;enhancing cell proliferation;blocking differentiation;and inducing angiogenesis.

An efficient aggregation-enhanced delayed fluorescence luminogen created with spiro donors and carbonyl acceptor for applications as an emitter and sensitizer in high-performance organic light-emitting diodes

Organic light-emitting diodes(OLEDs)fabricated using organic thermally activated delayed fluorescence materials as sensitizers have recently achieved significant advancements,but the serious efficiency roll-offs are still troublesome in most cases.Herein,a tailor-made multifunctional luminogen SBF-BP-SFAC containing 9,9′-spirobifluorene(SBF)and spiro[acridine-9,9-fluorene](SFAC)as electron donors and carbonyl as an electron acceptor is synthesized and characterized.SBF-BPSFAC has the advantages of high thermal stability,aggregation-enhanced delayed fluorescence,and balanced carrier transport ability,and prefers horizontal dipole orientation.Highly efficient OLEDs employing SBF-BP-SFAC as an emitter radiate intense cyan light with outstanding external quantum efficiencies(ηexts)of up to 30.6%.SBF-BP-SFAC can also serve as an excellent sensitizer for orange fluorescence,phosphorescence,and delayed fluorescence materials,providing excellent η exts of up to 30.3% with very small efficiency roll-offs due to the fast Förster energy transfer as well as exciton annihilation suppression by bulky spiro donors.These outstanding performances demonstrate the great potential of SBF-BP-SFAC as an emitter and sensitizer for OLEDs.

Promising interlayer sensitization strategy for the construction of high-performance blue hyperfluorescence OLEDs

Multi-resonance thermally activated delayed fluorescence(MR-TADF)materials are promising candidates for organic light-emitting diodes(OLEDs)with narrow electroluminescence(EL)spectra.Current researches focus on fabricating hyperfluorescence OLEDs to improve EL efficiencies of MR-TADF emitters by co-doping them with TADF sensitizers in a single host layer.However,in many cases,the polarity of the single host could be not suitable for both blue MRTADF emitters and blue TADF sensitizers,resulting in broadened EL spectra in high-polar hosts or decreased EL efficiencies in low-polar hosts.Herein,we wish to report an efficient sensitization strategy for blue MR-TADF emitters by constructing an interlayer-sensitizing configuration,in which the blue TADF sensitizers and blue MR-TADF emitters are separated into two closely aligned host layers with high polarity and low polarity,respectively.Based on this strategy,efficient blue hyperfluorescence OLEDs are realized and verified by employing various TADF sensitizers and different MR-TADF emitters,furnishing outstanding external quantum efficiencies of up to 38.8%and narrow EL spectra.These results validate the feasibility and universality of this interlayer sensitization strategy,which provides an effective alternative to high-performance blue hyperfluorescence OLEDs.