In spite of the extensive application of electroconvulsive therapy（ECT）, how it works remains unclear.So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment...In spite of the extensive application of electroconvulsive therapy（ECT）, how it works remains unclear.So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.展开更多
基金supported by the grants of Shanghai Hospital Development Center,China(SHDC12014111)the Science and Technology Commission of Shanghai Municipality,China(14411961400 and 13dz2260500)the Shanghai Health System Leadership in Health Research Program,China(XBR2011005)
文摘In spite of the extensive application of electroconvulsive therapy（ECT）, how it works remains unclear.So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.
