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Rational design of phosphonate/quaternary amine block polymer as an high-efficiency antibacterial coating for metallic substrates 被引量:6
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作者 Li Liu Wan peng +3 位作者 Xiao Zhang jiangmei peng Pingsheng Liu Jian Shen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第3期96-106,共11页
Developing advanced technologies to address the bacterial associated infections is an urgent requirement for metallic implants and devices.Here,we report a novel phosphonate/quaternary amine block polymer as the high-... Developing advanced technologies to address the bacterial associated infections is an urgent requirement for metallic implants and devices.Here,we report a novel phosphonate/quaternary amine block polymer as the high-efficiency antibacterial coating for metallic substrates.Three pDEMMP-b-pTMAEMA block polymers that bearing identical phosphonate segments(repeat units of 15)but varied cationic segments(repeat units of 8,45,and 70)were precisely prepared.Stable cationic polymer coatings were constructed on TC4 substrates based on the strong covalent binding between phosphonate group and metallic substrate.Robust relationship between the segment chain length of the polymer coating and the antibacterial property endowed to the substrates have been established based on quantitative and qualitative evaluations.Results showed that the antibacterial rate of the modified TC4 surface were 95.8%of S.aureus and 92.9%of E.coli cells attached.Interestingly,unlike the cationic free polymer or cationic hydrogels,the surface anchored cationic polymers do compromise the viability of the attached C2C12 cells but without significant cytotoxicity.In addition,the phosphonate/quate rnary amine block polymers can be easily constructed on titanium,stainless steel,and Ni/Cr alloy with significantly improved antibacterial property,indicating the generality of the block polymer for surface antibacterial modification of bio-metals. 展开更多
关键词 Block polymers Polymeric coating Metallic substrates POLYCATIONS Antibacterial property
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