An unusual negative 1H NMR chemical shift of methyl group was discovered in condensation product of isoco-palane diterpenoid with p-toluenesulfonyl hydrazide.2D NMR,computational studies and single-crystal X-ray dif-f...An unusual negative 1H NMR chemical shift of methyl group was discovered in condensation product of isoco-palane diterpenoid with p-toluenesulfonyl hydrazide.2D NMR,computational studies and single-crystal X-ray dif-fraction analysis showed that the C-20 methyl group was shielded.展开更多
This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(−)-Sclareol in 7 steps.The key step of this route relied on the cross coupling of the diterpene with the arene fragment u...This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(−)-Sclareol in 7 steps.The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed byβ-acetoxy elimination type Heck reaction.展开更多
基金supported by National Natural Science Foundation of China(No.21302053)Science and Technology Commission of Shanghai Mu-nicipality(No.14DZ1900102)the Fundamental Research Funds for the Central University(No.WY1113007)。
文摘An unusual negative 1H NMR chemical shift of methyl group was discovered in condensation product of isoco-palane diterpenoid with p-toluenesulfonyl hydrazide.2D NMR,computational studies and single-crystal X-ray dif-fraction analysis showed that the C-20 methyl group was shielded.
基金supported by the National Natural Science Foundation of China(No.21302053)Science and Technology Commission of Shanghai Mu-nicipality(No.14DZ1900102)the Fundamental Research Funds for the Central University(No.WY1113007).
文摘This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(−)-Sclareol in 7 steps.The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed byβ-acetoxy elimination type Heck reaction.
