DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be i...DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be infected with the SARS-CoV-2 prototype. Our results showed direct experimental evidence of the infectivity of SARS-CoV-2 infection, subsequent pathogenicity, and protection against reinfection in rats.展开更多
Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo ...Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials.展开更多
基金supported by the National Natural Science Foundation of China(U1902215 to Y.G.Y.,32070569 to L.X.)Applied Basic Research Foundation of Yunnan Province(202001AS070023 to D.Y.)+1 种基金Key Project of the CAS“Light of West China”Program(to D.Y.)。
文摘DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be infected with the SARS-CoV-2 prototype. Our results showed direct experimental evidence of the infectivity of SARS-CoV-2 infection, subsequent pathogenicity, and protection against reinfection in rats.
基金supported in part by grants from the Chinese Academy of Sciences(KSCX2-YW-R-110,KSCX2-YW-R-229,XDA01010403 to J.L.,KSCX1-YW-02,KJCX2-YW-M15 to J.W.)the Ministry of Science and Technology(2007CB947101,2009CB941101 to J.L.,2006CB503900,2010CB912102 to J.W.)+1 种基金the National Natural Science Foundation of China(30871430 to J.L.,30821065 to J.W.)the Shanghai Municipal Commission for Science and Technology(07DZ22919,08DJ1400502,09PJ1410900 to J.L.,07dz05907 to J.W.).
文摘Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials.
