期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Experimental models for cancer brain metastasis
1
作者 Zihao Liu Shanshan Dong +4 位作者 Mengjie Liu Yuqiang Liu Zhiming Ye jianhao zeng Maojin Yao 《Cancer Pathogenesis and Therapy》 2024年第1期15-23,共9页
Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Emp... Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Employing accurate in vitro and in vivo models to recapitulate the complexities of brain metastasis offers the most promising approach to unravel the intricate cellular and physiological processes involved.Here,we present a comprehensive review of the currently accessible models for studying brain metastasis.We introduce a diverse array of in vitro and in vivo models,including cultured cells using the Transwell system,organoids,microfluidic models,syngeneic models,xenograft models,and genetically engineered models.We have also provided a concise summary of the merits and limitations inherent to each model while identifying the optimal contexts for their effective utilization.This review serves as a comprehensive resource,aiding researchers in making well-informed decisions regarding model selection that align with specific research questions. 展开更多
关键词 Brain metastases Blood-brain barrier Animal model In vitro model
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部