Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecti...Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the renal interstitium,causing nephrocalcinosis.1 Although CaOx nephrocalcinosis is usually asymptomatic.展开更多
Idiopathic hypogonadotropic hypogonadism(IHH)is a rare genetic disease with clinical and genetic heterogeneity.This study aimed to investigate a novel causal gene of IHH and a homozygous mutation(p.Ala515Val)in SEMA4D...Idiopathic hypogonadotropic hypogonadism(IHH)is a rare genetic disease with clinical and genetic heterogeneity.This study aimed to investigate a novel causal gene of IHH and a homozygous mutation(p.Ala515Val)in SEMA4D,and sought to determine the mechanism of SEMA4D promoting GnRH neurons migration.展开更多
基金This work was supported by the National Natural Science Foundation of China(82070726,82060137,81970604,and 82100808)the Key Project of the Guangxi Natural Science Foundation(2020GXNSFDA297013)+2 种基金the China Postdoctoral Science Foundation(2021M690185)the Anhui Postdoctoral Science Foundation(2021A482)the Anhui Provincial Department of Education Research Project(KJ2020A0167).
文摘Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the renal interstitium,causing nephrocalcinosis.1 Although CaOx nephrocalcinosis is usually asymptomatic.
基金The project was supported by the National Natural Science Foundation of China(No.81671443 to J.L.,No.81601270 to H.X.)Tongji Hospital Clinical Research Flash Ship Program(China)(No.2019CR109).
文摘Idiopathic hypogonadotropic hypogonadism(IHH)is a rare genetic disease with clinical and genetic heterogeneity.This study aimed to investigate a novel causal gene of IHH and a homozygous mutation(p.Ala515Val)in SEMA4D,and sought to determine the mechanism of SEMA4D promoting GnRH neurons migration.