Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nano...Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.展开更多
The stability of the anchorage slope on the Baiyang Yangtze River Highway Bridge in Yichang,China,was investigated under different rainfall conditions using model test,numerical simulation,and factor analysis.The resu...The stability of the anchorage slope on the Baiyang Yangtze River Highway Bridge in Yichang,China,was investigated under different rainfall conditions using model test,numerical simulation,and factor analysis.The results of the study are as follows:(1)with the increase of rainfall intensity,the change of earth pressure can be divided into three stages.However,when the rainfall intensity was larger than a certain value,the change of earth pressure of cut slope became two stages;with the increase of rainfall intensity,pore water pressure increased with the increase of rainfall time,while at a certain stage after the rainfall,the pore water pressure in the cut slope did not decrease immediately,but increased for a period of time.(2)When the rainfall stopped,the stability coefficient of the anchorage slope continued to decrease,then slowly increased,and finally tended to be gentle.Meanwhile,when the rainstorm reached a certain intensity,the main factor that restricted the rainfall infiltration rate became the geotechnical permeability coefficient of the cut slope,which was no longer the rainfall intensity.(3)Factor analysis shows that the rainfall intensity and rainfall duration were the most important factors for anchorage slope stability,while earth pressure,pore water pressure and slope displacement were much less significant.展开更多
基金financially supported by the National Natural Science Foundation of China (31700689)Natural Science Foundation of Shanxi Province (201901D111115)+1 种基金Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S)Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015)
文摘Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.
基金the National Natural Science Foundation of China(Nos.41807265,41972286)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)(No.CUGQY1931)。
文摘The stability of the anchorage slope on the Baiyang Yangtze River Highway Bridge in Yichang,China,was investigated under different rainfall conditions using model test,numerical simulation,and factor analysis.The results of the study are as follows:(1)with the increase of rainfall intensity,the change of earth pressure can be divided into three stages.However,when the rainfall intensity was larger than a certain value,the change of earth pressure of cut slope became two stages;with the increase of rainfall intensity,pore water pressure increased with the increase of rainfall time,while at a certain stage after the rainfall,the pore water pressure in the cut slope did not decrease immediately,but increased for a period of time.(2)When the rainfall stopped,the stability coefficient of the anchorage slope continued to decrease,then slowly increased,and finally tended to be gentle.Meanwhile,when the rainstorm reached a certain intensity,the main factor that restricted the rainfall infiltration rate became the geotechnical permeability coefficient of the cut slope,which was no longer the rainfall intensity.(3)Factor analysis shows that the rainfall intensity and rainfall duration were the most important factors for anchorage slope stability,while earth pressure,pore water pressure and slope displacement were much less significant.
