In traditional electroforming process for revolving parts with complex profiles, the drawbacks on surface of deposits, such as pinholes and nodules, will lead to varying physical and mechanical properties on different...In traditional electroforming process for revolving parts with complex profiles, the drawbacks on surface of deposits, such as pinholes and nodules, will lead to varying physical and mechanical properties on different parts of electroformed components. To solve the problem, compositely moving cathode is employed in abrasive-assisted electroforming of revolving parts with complicated profiles. The cathode translates and rotates simultaneously to achieve uniform friction effect on deposits without drawbacks. The influences of current density and transla- tion speed on the microstructure and properties of the electroformed nickel layers are investigated. It is found that abrasive-assisted electroforming with compound cathode motion can effectively remove the pinholes and nodules, positively affect the crystal nucleation, and refine the grains of layer. The increase of current density will lead to coarse microstructure and lower micro hardness, from 325 HV down to 189 HV. While, faster translational linear speed produces better surface quality and higher micro hardness, from 236 HV up to 283 HV. The weld-ability of the electroformed layers are also studied through the metallurgical analysis of welded joints between nickel layer and 304 stainless steel. The electrodeposited nickel layer shows fine performance in welding. The novel compound motion of cathode promotes the mechanical properties and refines the microstructure of deposited layer.展开更多
Bleachers play a crucial role in practical engineering applications, and any damage incurred during their operationposes a significant threat to the safety of both life and property. Consequently, it becomes imperativ...Bleachers play a crucial role in practical engineering applications, and any damage incurred during their operationposes a significant threat to the safety of both life and property. Consequently, it becomes imperative to conductdamage diagnosis and health monitoring of bleachers. The intricate structure of bleachers, the varied types ofpotential damage, and the presence of similar vibration data in adjacent locations make it challenging to achievesatisfactory diagnosis accuracy through traditional time-frequency analysis methods. Furthermore, field environmentalnoise can adversely impact the accuracy of bleacher damage diagnosis. To enhance the accuracy and antinoisecapabilities of bleacher damage diagnosis, this paper proposes improvements to the existing ConvolutionalNeural Network with Training Interference (TICNN). The result is an advanced Convolutional Neural Networkmodel with superior accuracy and robust anti-noise capabilities, referred to as Enhanced TICNN (ETICNN).ETICNN autonomously extracts optimal damage-sensitive features from the original vibration data. To validatethe superiority of the proposed ETICNN, experiments are conducted using the bleacher model from Qatar Universityas the subject. Comparative studies under identical experimental conditions involve TICNN, Deep ConvolutionalNeural Networks with wide first-layer kernels (WDCNN), and One-Dimensional ConvolutionalNeural Network (1DCNN). The experimental findings demonstrate that the ETICNN model achieves the highestaccuracy, approximately 99%, and exhibits robust classification abilities in both Phases I and II of the damagediagnosis experiments. Simultaneously, the ETICNN model demonstrates strong anti-noise capabilities, outperformingTICNN by 3% to 4% and surpassing other models in performance.展开更多
Joint contracture is a fibrotic complication induced by joint immobilization and trauma,which is characterized as excessive myofibroblast proliferation in joint capsule.The treatments of joint contracture are unsatisf...Joint contracture is a fibrotic complication induced by joint immobilization and trauma,which is characterized as excessive myofibroblast proliferation in joint capsule.The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction.Our previous study has shown that curcumin can inhibit myofibroblast proliferation in vitro,but the major challenge is the low aqueous solubility and biological activity of curcumin.In this study,hyaluronic acid-curcumin(HA-Cur)conjugate was synthesized to suppress myofibroblasts in joint contracture.Cells were isolated from the joint capsules of joint contracture patients and induced to active myofibroblasts by transforming growth factor-b(TGF-b).The anti-fibrotic function and mechanisms of HA-Cur were investigated by immunohistochemistry,reverse transcription-quantitative polymerase chain reaction(PCR),methylation-specific PCR,western blot,transwell migration assay and proliferation assay.Results showed that 30 lM HA-Cur significantly attenuated the fibrotic functions of myofibroblast in joint contracture in vitro by regulating the methylation of prostaglandin E receptor 2(PTGER2)and inhibiting TGF-b signaling.This may provide a mechanism for the treatment of joint contracture,and provide a molecular target PTGER2 for therapy during the pathogenesis of joint contracture.展开更多
基金Supported by National Natural Science Foundation of China(Grant No.51475239)Program for New Century Excellent Talents in University of China(Grand No.NCET-10-0074)
文摘In traditional electroforming process for revolving parts with complex profiles, the drawbacks on surface of deposits, such as pinholes and nodules, will lead to varying physical and mechanical properties on different parts of electroformed components. To solve the problem, compositely moving cathode is employed in abrasive-assisted electroforming of revolving parts with complicated profiles. The cathode translates and rotates simultaneously to achieve uniform friction effect on deposits without drawbacks. The influences of current density and transla- tion speed on the microstructure and properties of the electroformed nickel layers are investigated. It is found that abrasive-assisted electroforming with compound cathode motion can effectively remove the pinholes and nodules, positively affect the crystal nucleation, and refine the grains of layer. The increase of current density will lead to coarse microstructure and lower micro hardness, from 325 HV down to 189 HV. While, faster translational linear speed produces better surface quality and higher micro hardness, from 236 HV up to 283 HV. The weld-ability of the electroformed layers are also studied through the metallurgical analysis of welded joints between nickel layer and 304 stainless steel. The electrodeposited nickel layer shows fine performance in welding. The novel compound motion of cathode promotes the mechanical properties and refines the microstructure of deposited layer.
基金the Nature Science Foundation of Hebei Province Grant No.E2020402060Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province(Hebei University of Engineering)under Grant 202206.
文摘Bleachers play a crucial role in practical engineering applications, and any damage incurred during their operationposes a significant threat to the safety of both life and property. Consequently, it becomes imperative to conductdamage diagnosis and health monitoring of bleachers. The intricate structure of bleachers, the varied types ofpotential damage, and the presence of similar vibration data in adjacent locations make it challenging to achievesatisfactory diagnosis accuracy through traditional time-frequency analysis methods. Furthermore, field environmentalnoise can adversely impact the accuracy of bleacher damage diagnosis. To enhance the accuracy and antinoisecapabilities of bleacher damage diagnosis, this paper proposes improvements to the existing ConvolutionalNeural Network with Training Interference (TICNN). The result is an advanced Convolutional Neural Networkmodel with superior accuracy and robust anti-noise capabilities, referred to as Enhanced TICNN (ETICNN).ETICNN autonomously extracts optimal damage-sensitive features from the original vibration data. To validatethe superiority of the proposed ETICNN, experiments are conducted using the bleacher model from Qatar Universityas the subject. Comparative studies under identical experimental conditions involve TICNN, Deep ConvolutionalNeural Networks with wide first-layer kernels (WDCNN), and One-Dimensional ConvolutionalNeural Network (1DCNN). The experimental findings demonstrate that the ETICNN model achieves the highestaccuracy, approximately 99%, and exhibits robust classification abilities in both Phases I and II of the damagediagnosis experiments. Simultaneously, the ETICNN model demonstrates strong anti-noise capabilities, outperformingTICNN by 3% to 4% and surpassing other models in performance.
基金grants from National Natural Science Foundation of China[81772368 and 81802184]Natural Science Foundation of Guangdong Province[2017A030310226]+1 种基金the Guangdong Traditional Chinese Medicine Bureau Research Fund[20181061]Medical Research Foundation of Guangdong[A2017003].
文摘Joint contracture is a fibrotic complication induced by joint immobilization and trauma,which is characterized as excessive myofibroblast proliferation in joint capsule.The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction.Our previous study has shown that curcumin can inhibit myofibroblast proliferation in vitro,but the major challenge is the low aqueous solubility and biological activity of curcumin.In this study,hyaluronic acid-curcumin(HA-Cur)conjugate was synthesized to suppress myofibroblasts in joint contracture.Cells were isolated from the joint capsules of joint contracture patients and induced to active myofibroblasts by transforming growth factor-b(TGF-b).The anti-fibrotic function and mechanisms of HA-Cur were investigated by immunohistochemistry,reverse transcription-quantitative polymerase chain reaction(PCR),methylation-specific PCR,western blot,transwell migration assay and proliferation assay.Results showed that 30 lM HA-Cur significantly attenuated the fibrotic functions of myofibroblast in joint contracture in vitro by regulating the methylation of prostaglandin E receptor 2(PTGER2)and inhibiting TGF-b signaling.This may provide a mechanism for the treatment of joint contracture,and provide a molecular target PTGER2 for therapy during the pathogenesis of joint contracture.