Greenhouse gas emissions during the COVID-19 pandemic from agriculture in China

To study the impact of the COVID-19 pandemic on agricultural carbon emissions in China,the greenhouse gas emissions generated by crop and livestock production,and agricultural material and energy inputs in China from 2019 to 2021 were systematically calculated.It was found that from 2019 to 2021,Net greenhouse gas emissions(NGHGE)from agriculture in China had an increasing trend.Methane emissions ranked first in NGHGE,with an annual proportion exceeding 65%and an increasing annual trend.CH_(4)emissions were primarily influenced by enteric fermentation and rice production.Nitrous oxide emissions accounted for around 22%of annual NGHGE and decreased from 2019 to 2021.The main sources of N_(2)O emissions were the use of nitrogen fertilizers and manure management.Carbon dioxide emissions accounted for about 18%annually,with diesel and agricultural electricity use contributing to over 60%of CO_(2)emissions.Soil carbon sequestration represented about a 6.1%lowering of NGHGE.The combined proportion of CH4 emissions from enteric fermentation and rice production accounted for over 50%of total GHG emissions.The changes in NGHGE were mainly caused by disturbance of the livestock industry during the pandemic.

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

The constitutive androstane receptor(CAR, NR3 I1) belongs to nuclear receptor superfamily.It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein(YAP) is a potent regulator of organ size. The aim of this study is to explore the role of YAP in CAR activation-induced hepatomegaly and liver regeneration.TCPOBOP-induced CAR activation on hepatomegaly and liver regeneration was evaluated in wildtype(WT) mice, liver-specific YAP-deficient mice, and partial hepatectomy(PHx) mice. The results demonstrate that TCPOBOP can increase the liver-to-body weight ratio in wild-type mice and PHx mice.Hepatocytes enlargement around central vein(CV) area was observed, meanwhile hepatocytesproliferation was promoted as evidenced by the increased number of KI67+cells around portal vein(PV)area. The protein levels of YAP and its downstream targets were upregulated in TCPOBOP-treated mice and YAP translocation can be induced by CAR activation. Co-immunoprecipitation results suggested a potential proteineprotein interaction of CAR and YAP. However, CAR activation-induced hepatomegaly can still be observed in liver-specific YAP-deficient(Yape/e) mice. In summary, CAR activation promotes hepatomegaly and liver regeneration partially by inducing YAP translocation and interaction with YAP signaling pathway, which provides new insights to further understand the physiological functions of CAR.