Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke

Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate longlasting brain injury.Extrasynaptic N-methyl-Daspartate receptors (esNMDARs) are the major cause of ischemic neuronal death.However,there is no inhibitor selectively ta rgeting esNMDARs without compromising the function of other"beneficial"syna ptic NMDARs.

Review of ultraviolet ageing mechanisms and anti-ageing methods for asphalt binders

Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder.

Variation of gravity before the Alxa Zuoqi M5.8 earthquake

In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation of gravity before the Alxa Zuoqi M5.8 earthquake. The relationship between gravity variation and the Alxa Zuoqi M5.8 earthquake was analyzed. The results showed that： （1） the severe variation in gravity field at the test sites before the Alxa Zuoqi M5.8 earthquake, as well as the subsequent accelerated rising, might be an earthquake precursor; （2） the Alxa Zuoqi M5.8 earthquake occurred at the turning point where the high-gravity gradient zone changed from the NE direction to NW.

Optical non-destructive techniques for small berry fruits: A review

Small berries including strawberry and blueberry are extensively consumed fruits with great economic values due to their characteristic flavor and appearance as well as potential health benefits.This review elaborated the optical non-destructive techniques viz.Vis-NIR spectroscopy,computer vision system,hyperspectral imaging,multispectral imaging,laser-induced method and thermal imaging,and their applications for quality and safety control of small berry fruits.The discussion regarding the photoacoustic technique,X-ray technique,Terahertz spectroscopy,odor imaging,micro-destructive testing and smart mobile terminal-based analyzer was also presented.Furthermore,we proposed our personal understanding of the technical challenges and further trends for these optical non-destructive techniques:1)owing to the relatively low detection limit,the so-called micro-destructive techniques may be alternative to the traditional non-destructive techniques in both practical and fundamental research;2)we suggest that the research articles like“collecting data first,and then modeling the relevant properties of agricultural products by machine learning”should be less produced in related fields.That's because such research methods are likely to be suspected of“cheating”.It is recommended that some modeling competitions can be carried out in the agricultural engineering field to avoid or reduce the“cheating”model.